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creatine gains
- Thread starter muscledog95
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revexrevex
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Spatts do yoou have the subscription to pubmed?
The amount of insulin that is required to augment creatine uptake is near supraphysiologic (means really high). To get there it would take at least 100 grams of pure glucose or maltodextrin to spike the insulin to that level.
See the following paper:
Am J Physiol. Vol. 275, Issue 6, E974-E979
Stimulatory effect of insulin on creatine accumulation in human skeletal muscle
G. R. Steenge, J. Lambourne, A. Casey, I. A. Macdonald, and P. L. Greenhaff
School of Biomedical Sciences, University Medical School, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom
This study investigated the effect of insulin on plasma and muscle creatine accumulation and limb blood flow in humans after creatine administration. Seven men underwent a 300-min euglycemic insulin clamp combined with creatine administration on four separate occasions. Insulin was infused at rates of 5, 30, 55, or 105 mU · m2 · min1, and on each occasion 12.4 g creatine was administered. During infusion of insulin at rates of 55 and 105 mU · m2 · min1, muscle total creatine concentration increased by 4.5 ± 1.4 (P < 0.05) and 8.3 ± 1.0 mmol/kg dry mass (P < 0.05), and plasma creatine concentrations were lower at specific time points compared with the 5 mU · m2 · min1 infusion rate. The magnitude of increase in calf blood flow (plethysmography) was the same irrespective of the rate of insulin infusion, and forearm blood flow increased to the same extent as the three highest infusion rates. These findings demonstrate that insulin can enhance muscle creatine accumulation in humans but only when present at physiologically high or supraphysiological concentrations. This response is likely to be the result of an insulin-mediated increase in muscle creatine transport rather than creatine delivery.
See the following paper:
Am J Physiol. Vol. 275, Issue 6, E974-E979
Stimulatory effect of insulin on creatine accumulation in human skeletal muscle
G. R. Steenge, J. Lambourne, A. Casey, I. A. Macdonald, and P. L. Greenhaff
School of Biomedical Sciences, University Medical School, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom
This study investigated the effect of insulin on plasma and muscle creatine accumulation and limb blood flow in humans after creatine administration. Seven men underwent a 300-min euglycemic insulin clamp combined with creatine administration on four separate occasions. Insulin was infused at rates of 5, 30, 55, or 105 mU · m2 · min1, and on each occasion 12.4 g creatine was administered. During infusion of insulin at rates of 55 and 105 mU · m2 · min1, muscle total creatine concentration increased by 4.5 ± 1.4 (P < 0.05) and 8.3 ± 1.0 mmol/kg dry mass (P < 0.05), and plasma creatine concentrations were lower at specific time points compared with the 5 mU · m2 · min1 infusion rate. The magnitude of increase in calf blood flow (plethysmography) was the same irrespective of the rate of insulin infusion, and forearm blood flow increased to the same extent as the three highest infusion rates. These findings demonstrate that insulin can enhance muscle creatine accumulation in humans but only when present at physiologically high or supraphysiological concentrations. This response is likely to be the result of an insulin-mediated increase in muscle creatine transport rather than creatine delivery.
Protein- and carbohydrate-induced augmentation of whole body creatine retention in humans
G. R. Steenge, E. J. Simpson, and P. L. Greenhaff
School of Biomedical Sciences, University Medical School, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom
It is concluded, first, that the ingestion of creatine in conjunction with ~50 g of protein and CHO is as effective at potentiating insulin release and creatine retention as ingesting creatine in combination with almost 100 g of CHO. Second, the stimulatory effect of insulin on creatine disposal was diminished within the initial 24 h of supplementation.
G. R. Steenge, E. J. Simpson, and P. L. Greenhaff
School of Biomedical Sciences, University Medical School, Queen's Medical Centre, Nottingham NG7 2UH, United Kingdom
It is concluded, first, that the ingestion of creatine in conjunction with ~50 g of protein and CHO is as effective at potentiating insulin release and creatine retention as ingesting creatine in combination with almost 100 g of CHO. Second, the stimulatory effect of insulin on creatine disposal was diminished within the initial 24 h of supplementation.
pwr_machine
New member
Definately a good point.spatts said:
