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Bueno... luego de sostener largas discuciones con dragofly, y xavier sobre la eficacia del tamoxifeno en post ciclo realmente me canse de no saber con exactitud si este farmaco funciona o no...
Ayer tube una mala noche con insomnio y me puse a revolver el pubmed por todos lados...
La verdad es ke encontre la respuesta a la gran duda de todo el mundo , el tamoxifeno si funciona para restaurar el eje... es casi igual de confiable ke el clomifeno , podria desirse ke los dos tienen la misma eficacia.
1: Fertil Steril. 2001 May;75(5):1024-6.
A prospective randomized trial comparing clomiphene citrate with tamoxifen
citrate for ovulation induction.
Boostanfar R, Jain JK, Mishell DR Jr, Paulson RJ.
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology
and Infertility, University of Southern California Keck School of Medicine, Los
Angeles, California 90033, USA.
OBJECTIVE: To compare the rates of ovulation and pregnancy after tamoxifen
citrate (TMX) or clomiphene citrate (CC) among anovulatory women with
infertility. DESIGN: Prospective randomized trial. SETTING: Infertility clinic
in a university teaching hospital. PATIENT(S): Eighty-six anovulatory women
under 40 years of age undergoing ovulation induction. INTERVENTION(S): The women
were assigned randomly to receive either TMX or CC on cycle days 5-9. MAIN
OUTCOME MEASURE(S): Rates of ovulation and pregnancy for the two treatment
modalities. RESULTS(S): The overall rate of ovulation in the TMX group was 50 of
113 (44.2%) and in the CC group, 41 of 91 (45.1%). There were 10 pregnancies in
the TMX group and 6 pregnancies in the CC group. The cycle fecundity per
ovulatory cycle was 20.0% in the TMX group and 14.6% in the CC group.
CONCLUSION(S): The overall rate of ovulation and pregnancy were similar with TMX
and CC. TMX is a suitable alternative agent to CC in the management of
anovulatory infertility.
Publication Types:
Clinical Trial
Randomized Controlled Trial
PMID: 11334921 [PubMed - indexed for MEDLINE]
En conclucion los dos farmacos funcionan eficasmente.
Excelente no es cierto? bueno aver ke sucede si usamos los dos juntos:
1: Fertil Steril. 1993 May;59(5):976-9.
A clomiphene citrate and tamoxifen citrate combination therapy: a novel therapy
for ovulation induction.
Suginami H, Kitagawa H, Nakahashi N, Yano K, Matsubara K.
Department of Obstetrics and Gynecology, Ehime University School of Medicine,
Japan.
OBJECTIVE: To assess the efficacy of a clomiphene citrate (CC) and tamoxifen
citrate (CC/tamoxifen) combination therapy in ovulation induction by comparing
with a CC alone therapy. DESIGN: A randomized cross-over study with CC alone and
CC/tamoxifen combination therapies for 20 normoprolactinemic anovulatory women.
Randomly selected 10 of the 20 women (group A) underwent a CC alone therapy (100
mg CC during cycle days 5 to 9) for the initial three consecutive treatment
cycles and a CC/tamoxifen combination therapy (50 mg CC and 20 mg tamoxifen
during cycle days 5 to 9) for the subsequent three consecutive treatment cycles.
The remaining 10 (group B) were treated similarly but with the inverse sequence.
Ovulation was documented when a high BBT phase persisted for 11 days or more,
when midluteal serum P levels exceeded 7 ng/mL (22.3 nmol/L), or when pregnancy
ensued. RESULTS: The rates of ovulatory/treated, pregnant/treated, and
pregnant/ovulatory cycles were 42 of 56 (75.0%), 3 of 47 (6.4%), and 3 of 35
(8.6%) for CC/tamoxifen, respectively. Those were 25 of 57 (43.9%), 1 of 48
(2.1%), and 1 of 21 (4.8%) for CC, respectively. Clomiphene citrate/tamoxifen
was more effective in ovulation induction than CC. All the pregnancies were
normal and single. None of the treatments was accompanied by any remarkable side
effects. CONCLUSION: Clomiphene citrate/tamoxifen is a novel treatment modality
of ovulation induction with high efficacy.
Publication Types:
Clinical Trial
Randomized Controlled Trial
PMID: 8486198 [PubMed - indexed for MEDLINE]
CONCLUCION: vemos en los dos estudios ke tanto el tamoxifeno como el clomifeno funcionan en un indice del 44% aproximadamente , pero cuando se usan en conjunto la eficacia aumenta al 75%.
La casualidad es ke yo ya me habia antepuesto y el post ciclo lo estoy llebando acabo con los dos farmacos... la ultima inyeccion de roids me la aplike hace 3 semanas..... si me preguntan... sentiste algun bajon?? no.. bajaste de peso? si , 1 kg , tu fuerza disminuyo? la verdad ke apenas note un desenso muy pekeño , tal ves de un 3% en algunos grupos... imperseptible.
Nos vemos.
Ayer tube una mala noche con insomnio y me puse a revolver el pubmed por todos lados...
La verdad es ke encontre la respuesta a la gran duda de todo el mundo , el tamoxifeno si funciona para restaurar el eje... es casi igual de confiable ke el clomifeno , podria desirse ke los dos tienen la misma eficacia.
1: Fertil Steril. 2001 May;75(5):1024-6.
A prospective randomized trial comparing clomiphene citrate with tamoxifen
citrate for ovulation induction.
Boostanfar R, Jain JK, Mishell DR Jr, Paulson RJ.
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology
and Infertility, University of Southern California Keck School of Medicine, Los
Angeles, California 90033, USA.
OBJECTIVE: To compare the rates of ovulation and pregnancy after tamoxifen
citrate (TMX) or clomiphene citrate (CC) among anovulatory women with
infertility. DESIGN: Prospective randomized trial. SETTING: Infertility clinic
in a university teaching hospital. PATIENT(S): Eighty-six anovulatory women
under 40 years of age undergoing ovulation induction. INTERVENTION(S): The women
were assigned randomly to receive either TMX or CC on cycle days 5-9. MAIN
OUTCOME MEASURE(S): Rates of ovulation and pregnancy for the two treatment
modalities. RESULTS(S): The overall rate of ovulation in the TMX group was 50 of
113 (44.2%) and in the CC group, 41 of 91 (45.1%). There were 10 pregnancies in
the TMX group and 6 pregnancies in the CC group. The cycle fecundity per
ovulatory cycle was 20.0% in the TMX group and 14.6% in the CC group.
CONCLUSION(S): The overall rate of ovulation and pregnancy were similar with TMX
and CC. TMX is a suitable alternative agent to CC in the management of
anovulatory infertility.
Publication Types:
Clinical Trial
Randomized Controlled Trial
PMID: 11334921 [PubMed - indexed for MEDLINE]
En conclucion los dos farmacos funcionan eficasmente.
Excelente no es cierto? bueno aver ke sucede si usamos los dos juntos:
1: Fertil Steril. 1993 May;59(5):976-9.
A clomiphene citrate and tamoxifen citrate combination therapy: a novel therapy
for ovulation induction.
Suginami H, Kitagawa H, Nakahashi N, Yano K, Matsubara K.
Department of Obstetrics and Gynecology, Ehime University School of Medicine,
Japan.
OBJECTIVE: To assess the efficacy of a clomiphene citrate (CC) and tamoxifen
citrate (CC/tamoxifen) combination therapy in ovulation induction by comparing
with a CC alone therapy. DESIGN: A randomized cross-over study with CC alone and
CC/tamoxifen combination therapies for 20 normoprolactinemic anovulatory women.
Randomly selected 10 of the 20 women (group A) underwent a CC alone therapy (100
mg CC during cycle days 5 to 9) for the initial three consecutive treatment
cycles and a CC/tamoxifen combination therapy (50 mg CC and 20 mg tamoxifen
during cycle days 5 to 9) for the subsequent three consecutive treatment cycles.
The remaining 10 (group B) were treated similarly but with the inverse sequence.
Ovulation was documented when a high BBT phase persisted for 11 days or more,
when midluteal serum P levels exceeded 7 ng/mL (22.3 nmol/L), or when pregnancy
ensued. RESULTS: The rates of ovulatory/treated, pregnant/treated, and
pregnant/ovulatory cycles were 42 of 56 (75.0%), 3 of 47 (6.4%), and 3 of 35
(8.6%) for CC/tamoxifen, respectively. Those were 25 of 57 (43.9%), 1 of 48
(2.1%), and 1 of 21 (4.8%) for CC, respectively. Clomiphene citrate/tamoxifen
was more effective in ovulation induction than CC. All the pregnancies were
normal and single. None of the treatments was accompanied by any remarkable side
effects. CONCLUSION: Clomiphene citrate/tamoxifen is a novel treatment modality
of ovulation induction with high efficacy.
Publication Types:
Clinical Trial
Randomized Controlled Trial
PMID: 8486198 [PubMed - indexed for MEDLINE]
CONCLUCION: vemos en los dos estudios ke tanto el tamoxifeno como el clomifeno funcionan en un indice del 44% aproximadamente , pero cuando se usan en conjunto la eficacia aumenta al 75%.
La casualidad es ke yo ya me habia antepuesto y el post ciclo lo estoy llebando acabo con los dos farmacos... la ultima inyeccion de roids me la aplike hace 3 semanas..... si me preguntan... sentiste algun bajon?? no.. bajaste de peso? si , 1 kg , tu fuerza disminuyo? la verdad ke apenas note un desenso muy pekeño , tal ves de un 3% en algunos grupos... imperseptible.
Nos vemos.
