Not really. Increasing the dose till you hit sides is a protocol for finding your sweet spot really. The receptors down regulate regardless I believe.
I've used clen before at higher doses for weeks and it worked well but the cramps and high heart rate always bothered me. The cramps would hit my neck mainly and they would hurt very badly, imagine at work in a meeting when I turn my head to talk and I get a neck cramp.....yea not pretty.
I'm hoping I can get the positives with 40mcgs while avoiding the negatives.
Looking forward to see how the cycle goes! Personally i dont mind the side's but the logical part of my brain know's the shit cant be good for the ol' ticker if you have any success with cycle ill prob try it out myself