I say Milk Thistle is just fine, but I never ran more than 25mg Superdrol and was taking Epistane along with it. I also have an extremely healthy diet (I mean truly extremely healthy) apart from these orals, so my liver and kidneys are already in great shape. Someone who frequently consumes alcohol and parties it up should be more cautious, especially if you are boozing on cycle. Alcohol is real tough on the liver, and when you add the harshness of a high protein diet and methylated compounds, serious complications begin to surface. My blood tests were actually really good after the FLM cycle. The usual elevated bad cholesterol and such were there, but recent blood tests show I've got it way back into superb health levels a month later. So depending on your lifestyle and your current health, Milk Thistle may or may not be enough. Do yourself a favor and get blood work done. Blood work is probably the only way to know with some certainty whether you are overdoing it or not during a cycle. I also recommend starting off with a minimal dose, even it it means only for a few days. Some people get bad sides from methyl compounds right away at low doses, even when they are experienced users, but are trying a new substance.