Arimidex vs Aromasin

[joe d]

here on ef we mostly see the use of arimidex being suggested. once in a while we see aromasin.

from a broader view the aromasin users seam to out number the adex users and many label adex a thing of the past or its use soely for hrt.

DrugsProfiles.com | Anti-Estrogens

please disguss.

 

[warrio2345]

Is it true there is no rebound at all from aromasin, so when I come off it my estro wont spike at all?

 

[joe d]

after reading im thinking aromasin may be the better choice for everyone providing there are no alergy type issues. but its still just a thought im investigating. i havent used it yet but probably will soon. lets get some input in here.

 

[joe d]

Is it true there is no rebound at all from aromasin, so when I come off it my estro wont spike at all?

thats the idea. no rebound since its suicidal, where the adex is not.

 

[warrio2345]

Bump, how do you avoid the adex rebound?

 

[joe d]

Joe for someone like myself who has been taking adex for a long peroid of time (6 months +, i'm scripted by my endo) if i wanted to come off it if needs be, should i taper down?? i wouldnt want to get the rebound effect, no no......

i dont know the answer to this one. tapering sounds logical.

 

[d_rson]

yes, slow taper down and watch for warning signs of rebound

I'm wondering if you could switch to aromasin 1 week before coming off adex and ease into aromasin and then come off aromasin, much like is recommended when combining adex and aromasin in a cycle. The aromasin prevents the estro rebound by killing it.

 

[joe d]

bump for more input

 

[rikishi]

ABSTRACT FROM JOURNAL OF CLINICAL ENDOCRONOLOGY AND METABOLISM

Suppression of estrogen, via estrogen receptor or aromatase blockade, is being investigated in the treatment of different conditions. Exemestane (Aromasin) is a potent and selective irreversible aromatase inhibitor. To characterize its suppression of estrogen and its pharmacokinetic (PK) properties in males, healthy eugonadal subjects were recruited. In a cross-over study, 12 were randomly assigned to 25 and 50 mg exemestane daily, orally, for 10 d with a 14-d washout period. Blood was withdrawn before and 24 h after the last dose of each treatment period. A PK study was performed (n = 10) using a 25-mg dose.

RESULTS :

The 25- and 50-mg doses of daily exemestane had comparable effects in suppressing circulating estrogen concentrations, with 38 ± 24% (mean ± SD; P = 0.002 vs. baseline) and 32 ± 29% (P = 0.008) decreases in estradiol concentrations, 71 ± 12% (P < 0.0001) and 74 ± 12% (P < 0.0001) decreases in estrone concentrations, and 45 ± 27% (P = 0.004) and 51 ± 20% (P = 0.02)

BUT THERE'S MORE

There was an increase in circulating testosterone concentrations after both 25 mg (60 ± 58%; P = 0.001) and 50 mg (56 ± 48%; P = 0.003) exemestane. Androstenedione concentrations were increased as well after 25 mg (32 ± 36%; P = 0.004) and 50 mg (47 ± 59%; P = 0.052) exemestane, respectively (Fig. 1Go and Table 2Go).

SHBG concentrations were decreased by 21 ± 7% (P = 0.0003) and 19 ± 39% (P = 0.18) at 25 and 50 mg exemestane, respectively.

Free testosterone concentrations were increased by 117 ± 74% (P = 0.0001) and 154 ± 95% (P < 0.0001) at both doses, due to the decrease in SHBG and the increase in total testosterone.

THE ICING ON THE CAKE !

There were no changes in circulating serum triglycerides, cholesterol, or LDL or HDL cholesterol concentrations with either dose of exemestane.

A study done on Aromasin.

 

[OMEGA]

Just to make friend happy

I will pick between Aromasen or Formastane

Sorry Adex and Nolva are not the same
Will they do if no others Around? Sure
Are they superior NO

 

[sion]

on cycle arimidex is a safe and proven to work and on cycle there is no worries about rebound when you come off cycle you dont have enough test to be problematic.In pct and stand alone cycles aromasin may be a better option because it doesnt rebound and does not crush estrogen like arimidex.

 

[big_daws]

NEITHER!!!

go with Formestane...ive been on it for 4 days and my sides are practically gone already. I will never do a cycle without it ever again.

 

[Nelson Montana]

Dex does not have that severe of a severe rebound. Nolva does.

I like both. They're similar and each have advantages. I alternate.

Formastane has the sexual sides which dex and sin do not.

And clomid and nolva just blow balls. (But you knew I was going to say that, didn;t cha?).

 

[rikishi]

Dex does not have that severe of a severe rebound. Nolva does.

I like both. They're similar and each have advantages. I alternate.

Formastane has the sexual sides which dex and sin do not.

And clomid and nolva just blow balls. (But you knew I was going to say that, didn;t cha?).

What kind of sexual sides come with Formastane?

 

[Ross]

It depends on your goals, but Aromasin is the wisest choice for most men. Letro is amazing if you utilize it PROPERLY:

CLINICAL STUDIES
Letrozole once a week normalizes serum testosterone in obesity-related male hypogonadism
Sandra Loves1, Janneke Ruinemans-Koerts2 and Hans de Boer1

Departments of1 , Internal Medicine2 Clinical Chemistry, Ziekenhuis Rijnstate, Wagnerlaan 55, 6800 TA Arnhem, The Netherlands

(Correspondence should be addressed to H de Boer; Email: [email protected])


Abstract
Top
Abstract
Introduction
Patients and methods
Results
Discussion
References

Objective: Isolated hypogonadotropic hypogonadism (IHH) is frequently observed in severely obese men, probably as a result of increased estradiol (E2) production and E2-mediated negative feedback on pituitary LH secretion. Aromatase inhibitors can reverse this process. This study evaluates whether letrozole once a week can normalize serum testosterone in severely obese men and maintain its long term effect.

Design: Open, uncontrolled 6-month pilot study in 12 severely obese men (body mass index>35.0 kg/m2) with obesity-related IHH and free testosterone levels <225 pmol/l, treated with 2.5 mg letrozole once a week for 6 months.

Results: Six weeks of treatment reduced total E2 from 123±11 to 58±7 pmol/l (P<0.001, mean±S.E.M.), and increased serum LH from 4.4±0.6 to 11.1±1.5 U/l (P<0.001). Total testosterone rose from 5.9±0.5 to 19.6±1.4 nmol/l (P<0.001), and free testosterone from 163±13 to 604±50 pmol/l (P<0.001). Total testosterone rose to within the normal range in all subjects, whereas free testosterone rose to supraphysiological levels in 7 out of 12 men. The testosterone and E2 levels were stable throughout the week and during the 6-month treatment period.

Conclusion: Letrozole 2.5 mg once a week produced a sustained normalization of serum total testosterone in obese men with IHH. However, free testosterone frequently rose to supraphysiological levels. Therefore, a starting dose <2.5 mg once a week is recommended.

 

[wolfman87]

i'm an aromasin man through and through. it kills any acne/bacne for me as well. too bad it doesn't do that for everyone.

 

[st8grad]

i'm an aromasin man through and through. it kills any acne/bacne for me as well. too bad it doesn't do that for everyone.

Kills acne/bacne for you?

Nice, does Aromasin help with overall oiliness on cycle?

I'm on cyp/tren and glossy like a college brochure. I don't ever remember being this oily on. Taking a-dex as my AI, but if Aromasin can help in the greasy category I'd switch.

Sorry for the hijack.

Also, I have read that formestane has a very low bioavailability.