another f'd up blood work !!!!!

[6FULLMETALTRUCKIE9]

This is my 3 set of blood work this year and it just seems to get worse the harder I try to improve it! Everything is ok but my liver enzymes they are as follows :
AST (SGOT) 192 U/L 10-40
ALT (SGPT) 254 U/L 10/45
ALK PHOS 281 U/L 30-120
So as you can see they are all really up there and this is been the norm for most of this year.I don't have a fatty liver or any other issues from all the test I've taken and have been told I'm fine . Just my luck I'd do a cycle and end up in a pine box! I really just want a idea why this is happening I mean I don't drink and haven't done any gear for 15 years now.Could this be from me being a type one diabetic insulin dependant ? Any help would be great people! Thanks

 

[Tatyana]

It does appear that it is another thing you have to deal with due to your diabetes hun


The link has the full paper.



Elevated Liver Function Tests in Type 2 Diabetes -- Harris 23 (3): 115 -- Clinical Diabetes
Clinical Diabetes 23:115-119, 2005
© American Diabetes Association ®, Inc., 2005

--------------------------------------------------------------------------------

Feature Article

Elevated Liver Function Tests in Type 2 Diabetes
Elizabeth H. Harris, MD


IN BRIEF

Individuals with type 2 diabetes have a higher incidence of liver function test abnormalities than individuals who do not have diabetes. Mild chronic elevations of transaminases often reflect underlying insulin resistance. Elevation of transaminases within three times the upper limits of normal is not a contraindication for starting oral antidiabetic or lipid-modifying therapy. In contrast, antidiabetic agents have generally been shown to decrease alanine aminotransferase levels as tighter blood glucose levels are achieved.

 

[Tatyana]

Prevalence of abnormal liver function tests in patients with diabetes mellitus

Sherif Gonem1, Alan Wall2 & Parijat De1

1Diabetes & Endocrine Unit, City Hospital, Birmingham, United Kingdom; 2Department of Biochemistry, City Hospital, Birmingham, United Kingdom.


--------------------------------------------------------------------------------

Background: A number of reports have associated non-alcoholic steatohepatitis (NASH) with aspects of the metabolic syndrome, such as insulin resistance, dyslipidaemia, type 2 diabetes and obesity. NASH can progress to cirrhosis and hepato-cellular carcinoma, as well as acting as a marker for insulin resistance in patients with type 2 diabetes mellitus.

Aims: The purpose of this study was to determine the prevalence of abnormal liver function in a population of, mainly type 2, diabetic patients, and to assess the feasibility of screening for NASH in this cohort of patients.

Methods: As part of new diabetes assessment, all patients referred to the diabetes clinic in our hospital had liver function measured routinely. We looked mainly at alanine aminotransferase (ALT), alkaline phosphatase (ALP) and bilirubin levels in a total of 959 patients who were tested over a four-year period. We calculated the prevalence of individual abnormal liver function and a combination of 2 or more LFT abnormality in this cohort of patients retrospectively.

Results: 151 patients (15.7%) had raised ALT, 100 patients (10.4%) had raised ALP and 37 patients (3.9%) had a raised bilirubin. The combination of raised bilirubin and ALT was seen in 10 patients (1.0%), bilirubin and ALP was seen in 7 patients (0.7%) and both ALP and ALT were raised in 27 patients (2.8%). Only 3 patients (0.3%) had all three abnormal liver function tests.

Conclusion: A high proportion of patients with diabetes mellitus in our catchment population have abnormal liver function tests that may be a marker for NASH and insulin resistance. Currently, routine liver function screening is not being advocated in type 2 diabetics but emerging evidence suggests that abnormal LFT may be a marker for metabolic syndrome and insulin resistance in type 2 diabetes. Such patients would thus warrant more intensive metabolic control particularly of their hyperglycaemia and dyslipidaemia and also their obesity and hypertension to not only reduce cardiovascular risk attributed to by their insulin resistance but also to prevent progression to significant hepatic dysfunction like cirrhosis and hepato-cellular carcinoma.


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Endocrine Abstracts (2007) 13 P157

 

[Tatyana]

I am being cheeky now


Deranged liver function tests in type 1 diabetes mellitus: an unusual presentation of Treponema pallidum infection
Author: Jamieson A.1

Source: European Journal of Internal Medicine, Volume 14, Number 2, March 2003 , pp. 113-115(3)

Publisher: Elsevier


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Key: - Free Content - New Content - Subscribed Content - Free Trial Content


Keywords: Syphilis; Diabetes mellitus; Deranged liver function tests

Language: English

Document Type: Short communication

DOI: 10.1016/S0953-6205(02)00218-2

Affiliations: 1: Department of Diabetes and Endocrinology, Queen Margaret Hospital, KY12 0SU, Dunfermline, UK

 

[blz]

Did they do a GGT level too?

 

[6FULLMETALTRUCKIE9]

Did they do a GGT level too?

No that's the next test I guess my doc's some what slow thinking of finding a more aggressive one to treat my Diabetes!!

 

[6FULLMETALTRUCKIE9]

I am being cheeky now


Deranged liver function tests in type 1 diabetes mellitus: an unusual presentation of Treponema pallidum infection
Author: Jamieson A.1

Source: European Journal of Internal Medicine, Volume 14, Number 2, March 2003 , pp. 113-115(3)

Publisher: Elsevier


< previous article | next article > | view table of contents



Key: - Free Content - New Content - Subscribed Content - Free Trial Content


Keywords: Syphilis; Diabetes mellitus; Deranged liver function tests

Language: English

Document Type: Short communication

DOI: 10.1016/S0953-6205(02)00218-2

Affiliations: 1: Department of Diabetes and Endocrinology, Queen Margaret Hospital, KY12 0SU, Dunfermline, UK

cheeky my ass it's nice to know this isn't a unheard of issue! Once again Girl you sved my ass from going insane! Thanks for all the info and that web site has tons of info thank you Love! Keep it up I'm going to have to tell my wife about you LOL

 

[Tatyana]

No that's the next test I guess my doc's some what slow thinking of finding a more aggressive one to treat my Diabetes!!

If your other amino transferase enzymes are elevated, so will your GGT.

I guess you didn't notice that the last paper was about an elevation due to syphillis then

 

[blz]

If your other amino transferase enzymes are elevated, so will your GGT.

I guess you didn't notice that the last paper was about an elevation due to syphillis then

A markedly elevated GGT would support a cholestatic process (coupled with the elevated alk phos) or some type of drug causing increased hepatic microsomal GGT induction (alcohol, barbituates, phenytoin, etc.)

I'm not saying that's all you need, but his LFTs are hardly complete. He also needs to give a full history to an astute physician as well.

 

[6FULLMETALTRUCKIE9]

If your other amino transferase enzymes are elevated, so will your GGT.

I guess you didn't notice that the last paper was about an elevation due to syphillis then

when this first hit me they ran every test they could to see what was wrong with me and that whole STD pannel came back clear so no drippy dick here love! It was strange I went from healthy to near death looking in 3 months thought I had the HIV after that last blood soaked JAWS of life job I had when I was in the Fire Department. I had some ladies skull open on the A pillar of the car and as I was cutting her out and she just bleed all over my arms and hands . Thank god for turnout gear with a bio rating! But they did say it's got something to do with my insulin resistance and morphine usage over these past years.So do you guys think I could use some of these new designer roids to help put some mass back on or just stick to pinning to avoid that liver stress of the first pass of orals?????Tatyana your a Goddess incarnate !!! Thanks for being the angle on my shoulder!FMT