Please Scroll Down to See Forums Below I have been using an Advair inhaler twice a day for about a month now (250mcg fluticasone propionate/50mcg Salmeterol). The fluticasone is a corticosteroid and the salmeterol a beta-agonist. Would this hae any negative/positive effects on gains? Althougth the Corticosteroid is a smaller concentration would this effect muscle growth or make it harder?...I am not on any AS. Just high protein, glutamine, creatine, and soon 1-Test (or related compound)...could the salmeterol help gains?
Advair inhaler....effects on gains?
- Thread starter Rogue47
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Salmeterol is a selective beta-2 agonist. It works by stimulation of adenyl cyclase with converts ATP to cAMP. Increasing levels of cAMP causes relaxation of brochial smooth muscle. Recent studies have shown that increasing cAMP levels may stimulate testosterone production (I will try to find and post this). Salmeterol is considered a 12 hour drug, hence the 2 x's a day dosing.
Fluticasone is a glucocorticoid (inhaled prednisone). Obviously a much lower dose do to the fact it is being administered right in the lungs where it is needed. There has been arguments as to how much of the drug is absorbed in to the system. Compared to oral prednisone, it is minimal. Regardless, you have been prescibed Advair because you have inflammed airways. If you stop you will rebound with breathing problems. What you should concern yourself with is getting on a lower dose. Glaxo-wellcome make Advair in 3 doses you are on the middle. I believe the lower dose is half that at 110mcg. Most importantly you need to take the medication every day because it will not work during an acute attack it is used to prevent them.
Overall I don't think it will significantly hurt your gains.
Two questions I have are do you suffer from allergies and what other medications are you on?
Fluticasone is a glucocorticoid (inhaled prednisone). Obviously a much lower dose do to the fact it is being administered right in the lungs where it is needed. There has been arguments as to how much of the drug is absorbed in to the system. Compared to oral prednisone, it is minimal. Regardless, you have been prescibed Advair because you have inflammed airways. If you stop you will rebound with breathing problems. What you should concern yourself with is getting on a lower dose. Glaxo-wellcome make Advair in 3 doses you are on the middle. I believe the lower dose is half that at 110mcg. Most importantly you need to take the medication every day because it will not work during an acute attack it is used to prevent them.
Overall I don't think it will significantly hurt your gains.
Two questions I have are do you suffer from allergies and what other medications are you on?
Thanks for the info! I am on no other meds. I was on Medrol dose pack (methylprednisolone) for 6 days, 2 weeks ago. I do have allergies but only pollen and usually just during spring. I was getting winded WAY to easily and knew something wasnt right. Doc said lungs were tight (constrictedand inflammed) I was prescribed the medrol (finished with that) and the Advair. Advair is only for 1 month (1 week to go/1 refill). Breathing is better but not completely. Doc said should be better after the medrol and a month or two of Advair. Very strange considering I never smoked, never smoked weed, don't work with irritating chemicals..etc.. Your input is very helpful..Will the advair help correct this or will i become dependant? Thanks again!
Asthma may be caused by heredity or environmental factors. Researchers have actually found a genes that cause it. If asthma goes untreated or even if it is treated but a person has chronic symptoms, the lung tissue goes through physiologic changes. As you get older, symptoms will worsen and drugs will be less effective. First of all I have to stress that if you have frequent symptoms B]on medication[/B] you should be seen by a pulmonologist, not a general practitioner . If your GP refuses to give you a referal I would call your health care carrier and tell them you need to be seen by another MD because you feel your being mismanaged. Second, If you have any notable allergies with year-round asthma symptoms I would also suggest allergy testing. You may be able to significantly reduce your medication by avoiding triggers of your asthma
liftsiron
New member
Salmeterol is a selective beta-2 agonist. It works by stimulation of adenyl cyclase with converts ATP to cAMP. Increasing levels of cAMP causes relaxation of brochial smooth muscle. Recent studies have shown that increasing cAMP levels may stimulate testosterone production (I will try to find and post this). Salmeterol is considered a 12 hour drug, hence the 2 x's a day dosing.
Fluticasone is a glucocorticoid (inhaled prednisone). Obviously a much lower dose do to the fact it is being administered right in the lungs where it is needed. There has been arguments as to how much of the drug is absorbed in to the system. Compared to oral prednisone, it is minimal. Regardless, you have been prescibed Advair because you have inflammed airways. If you stop you will rebound with breathing problems. What you should concern yourself with is getting on a lower dose. Glaxo-wellcome make Advair in 3 doses you are on the middle. I believe the lower dose is half that at 110mcg. Most importantly you need to take the medication every day because it will not work during an acute attack it is used to prevent them.
Overall I don't think it will significantly hurt your gains.
Two questions I have are do you suffer from allergies and what other medications are you on?
Bozzman I don't know where you came from but I certainly hope that you stay, you know what you are speaking of. Great post.
Fluticasone is a glucocorticoid (inhaled prednisone). Obviously a much lower dose do to the fact it is being administered right in the lungs where it is needed. There has been arguments as to how much of the drug is absorbed in to the system. Compared to oral prednisone, it is minimal. Regardless, you have been prescibed Advair because you have inflammed airways. If you stop you will rebound with breathing problems. What you should concern yourself with is getting on a lower dose. Glaxo-wellcome make Advair in 3 doses you are on the middle. I believe the lower dose is half that at 110mcg. Most importantly you need to take the medication every day because it will not work during an acute attack it is used to prevent them.
Overall I don't think it will significantly hurt your gains.
Two questions I have are do you suffer from allergies and what other medications are you on?
Bozzman I don't know where you came from but I certainly hope that you stay, you know what you are speaking of. Great post.
morningwood
New member
Ive used advair for nearly two years now and have had no problems with strength gains. My allergist prescribed two doses a day but i think this is a generous dosage. Recently, i have been taking one dose in the evening since night symptoms are worse and im still symptom free.
NitroPositive
New member
My asthma is allergy induced as yours appears to be so I can relate to you. I use the Advair 100/50 twice daily. I have been using it for almost three months and have not experienced any of the dreaded side effects associated with systemic glucocorticoids (prednisone).
A drug you might try and one I have had positive results with is Singulair. One 10mg tablet is taken in the evening. I particularly like the Singulair because of it's action. It is not a beta-2 agonist, nor a steroid. It is a leukotriene receptor antagonist. Leukotrienes fall under a class of hormone mediators called eicanosoids. There are good ones and bad ones. Leukotrienes are associated with the inflammatory process of asthma, and this drug blocks their action.
Before this combination, I would use the albuterol inhaler 4-5 times per day, and frequently use prednisone. Now I have not used my rescue inhaler in months.
Just my two cents - hope this helps!
A drug you might try and one I have had positive results with is Singulair. One 10mg tablet is taken in the evening. I particularly like the Singulair because of it's action. It is not a beta-2 agonist, nor a steroid. It is a leukotriene receptor antagonist. Leukotrienes fall under a class of hormone mediators called eicanosoids. There are good ones and bad ones. Leukotrienes are associated with the inflammatory process of asthma, and this drug blocks their action.
Before this combination, I would use the albuterol inhaler 4-5 times per day, and frequently use prednisone. Now I have not used my rescue inhaler in months.
Just my two cents - hope this helps!
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