Please Scroll Down to See Forums Below I have been using an Advair inhaler twice a day for about a month now (250mcg fluticasone propionate/50mcg Salmeterol). The fluticasone is a corticosteroid and the salmeterol a beta-agonist. Would this hae any negative/positive effects on gains? Althougth the Corticosteroid is a smaller concentration would this effect muscle growth or make it harder?...I am not on any AS. Just high protein, glutamine, creatine, and soon 1-Test (or related compound)...could the salmeterol help gains?
Advair inhaler....effects on gains?
- Thread starter Rogue47
- Start date
Salmeterol is a selective beta-2 agonist. It works by stimulation of adenyl cyclase with converts ATP to cAMP. Increasing levels of cAMP causes relaxation of brochial smooth muscle. Recent studies have shown that increasing cAMP levels may stimulate testosterone production (I will try to find and post this). Salmeterol is considered a 12 hour drug, hence the 2 x's a day dosing.
Fluticasone is a glucocorticoid (inhaled prednisone). Obviously a much lower dose do to the fact it is being administered right in the lungs where it is needed. There has been arguments as to how much of the drug is absorbed in to the system. Compared to oral prednisone, it is minimal. Regardless, you have been prescibed Advair because you have inflammed airways. If you stop you will rebound with breathing problems. What you should concern yourself with is getting on a lower dose. Glaxo-wellcome make Advair in 3 doses you are on the middle. I believe the lower dose is half that at 110mcg. Most importantly you need to take the medication every day because it will not work during an acute attack it is used to prevent them.
Overall I don't think it will significantly hurt your gains.
Two questions I have are do you suffer from allergies and what other medications are you on?
Fluticasone is a glucocorticoid (inhaled prednisone). Obviously a much lower dose do to the fact it is being administered right in the lungs where it is needed. There has been arguments as to how much of the drug is absorbed in to the system. Compared to oral prednisone, it is minimal. Regardless, you have been prescibed Advair because you have inflammed airways. If you stop you will rebound with breathing problems. What you should concern yourself with is getting on a lower dose. Glaxo-wellcome make Advair in 3 doses you are on the middle. I believe the lower dose is half that at 110mcg. Most importantly you need to take the medication every day because it will not work during an acute attack it is used to prevent them.
Overall I don't think it will significantly hurt your gains.
Two questions I have are do you suffer from allergies and what other medications are you on?
Thanks for the info! I am on no other meds. I was on Medrol dose pack (methylprednisolone) for 6 days, 2 weeks ago. I do have allergies but only pollen and usually just during spring. I was getting winded WAY to easily and knew something wasnt right. Doc said lungs were tight (constrictedand inflammed) I was prescribed the medrol (finished with that) and the Advair. Advair is only for 1 month (1 week to go/1 refill). Breathing is better but not completely. Doc said should be better after the medrol and a month or two of Advair. Very strange considering I never smoked, never smoked weed, don't work with irritating chemicals..etc.. Your input is very helpful..Will the advair help correct this or will i become dependant? Thanks again!
Asthma may be caused by heredity or environmental factors. Researchers have actually found a genes that cause it. If asthma goes untreated or even if it is treated but a person has chronic symptoms, the lung tissue goes through physiologic changes. As you get older, symptoms will worsen and drugs will be less effective. First of all I have to stress that if you have frequent symptoms B]on medication[/B] you should be seen by a pulmonologist, not a general practitioner . If your GP refuses to give you a referal I would call your health care carrier and tell them you need to be seen by another MD because you feel your being mismanaged. Second, If you have any notable allergies with year-round asthma symptoms I would also suggest allergy testing. You may be able to significantly reduce your medication by avoiding triggers of your asthma
liftsiron
New member
Salmeterol is a selective beta-2 agonist. It works by stimulation of adenyl cyclase with converts ATP to cAMP. Increasing levels of cAMP causes relaxation of brochial smooth muscle. Recent studies have shown that increasing cAMP levels may stimulate testosterone production (I will try to find and post this). Salmeterol is considered a 12 hour drug, hence the 2 x's a day dosing.
Fluticasone is a glucocorticoid (inhaled prednisone). Obviously a much lower dose do to the fact it is being administered right in the lungs where it is needed. There has been arguments as to how much of the drug is absorbed in to the system. Compared to oral prednisone, it is minimal. Regardless, you have been prescibed Advair because you have inflammed airways. If you stop you will rebound with breathing problems. What you should concern yourself with is getting on a lower dose. Glaxo-wellcome make Advair in 3 doses you are on the middle. I believe the lower dose is half that at 110mcg. Most importantly you need to take the medication every day because it will not work during an acute attack it is used to prevent them.
Overall I don't think it will significantly hurt your gains.
Two questions I have are do you suffer from allergies and what other medications are you on?
Bozzman I don't know where you came from but I certainly hope that you stay, you know what you are speaking of. Great post.
Fluticasone is a glucocorticoid (inhaled prednisone). Obviously a much lower dose do to the fact it is being administered right in the lungs where it is needed. There has been arguments as to how much of the drug is absorbed in to the system. Compared to oral prednisone, it is minimal. Regardless, you have been prescibed Advair because you have inflammed airways. If you stop you will rebound with breathing problems. What you should concern yourself with is getting on a lower dose. Glaxo-wellcome make Advair in 3 doses you are on the middle. I believe the lower dose is half that at 110mcg. Most importantly you need to take the medication every day because it will not work during an acute attack it is used to prevent them.
Overall I don't think it will significantly hurt your gains.
Two questions I have are do you suffer from allergies and what other medications are you on?
Bozzman I don't know where you came from but I certainly hope that you stay, you know what you are speaking of. Great post.
morningwood
New member
Ive used advair for nearly two years now and have had no problems with strength gains. My allergist prescribed two doses a day but i think this is a generous dosage. Recently, i have been taking one dose in the evening since night symptoms are worse and im still symptom free.
NitroPositive
New member
My asthma is allergy induced as yours appears to be so I can relate to you. I use the Advair 100/50 twice daily. I have been using it for almost three months and have not experienced any of the dreaded side effects associated with systemic glucocorticoids (prednisone).
A drug you might try and one I have had positive results with is Singulair. One 10mg tablet is taken in the evening. I particularly like the Singulair because of it's action. It is not a beta-2 agonist, nor a steroid. It is a leukotriene receptor antagonist. Leukotrienes fall under a class of hormone mediators called eicanosoids. There are good ones and bad ones. Leukotrienes are associated with the inflammatory process of asthma, and this drug blocks their action.
Before this combination, I would use the albuterol inhaler 4-5 times per day, and frequently use prednisone. Now I have not used my rescue inhaler in months.
Just my two cents - hope this helps!
A drug you might try and one I have had positive results with is Singulair. One 10mg tablet is taken in the evening. I particularly like the Singulair because of it's action. It is not a beta-2 agonist, nor a steroid. It is a leukotriene receptor antagonist. Leukotrienes fall under a class of hormone mediators called eicanosoids. There are good ones and bad ones. Leukotrienes are associated with the inflammatory process of asthma, and this drug blocks their action.
Before this combination, I would use the albuterol inhaler 4-5 times per day, and frequently use prednisone. Now I have not used my rescue inhaler in months.
Just my two cents - hope this helps!
ichabodcrane
New member
Bozzman said:
The concern here is only with enzymatic metabolism, and mainly applies to the leukotriene inhibitor Zileuton. All of these drugs are metabolized by CYP3A4. So you can imagine what happens when you throw in a bunch of drugs that are all metabolized by the same enzyme. You guessed it, increased risk of toxicities. Zileuton appears to be a worse offender than the leukotriene antagonists, Singulair and Accolate, although these to are metabolized by the same enzyme. You will see a red flag on testosterone because usually the concern is with the oral form which we know requires more hepatic metabolism. Don't think that injectibles aren't metabolized in the liver because they are(as well as other tissues). But they are not subject to first pass. So main concern with this issue would be your oral AAS.
For Rogue, you need not worry about systemic absorption using Advair. Bozz did a good job summing things up. You take what is considered a medium dose (264-660 ug/day). Low dose is 88-264 ug/day. Just be sure to rinse your mouth with water and spit after each use. Practitioners can approach asthma therapy 1 of 2 ways, and depending on your classification. Once you are diagnosed with asthma you are placed in a certain category or "step". Step 1 is mild-intermittent, step 2 is mild persistend, all the way up to step 4 which is severe-persistent. Anyways, like I said the practitioner can address treatment in 1 of 2 ways. They can start high and step down, or start at the initial level of severity and step up. Not that one is better than the other, but as you can gather starting high gets your symptoms under control faster, but may subject you to more side effects depending on which meds you are on(like the oral corticos). You said you were prescribed the medrol dose pack. I don't know which step you were classified in, but your symptoms must have been pretty severe. Usually we see people classified in step 3 (moderate-persistent) using the medium dosed inhaled corticosteroids in conjunction with a long acting beta 2 agonist. Depending on your response, it may be possible to step down in treatment. You should be reevaluated every 1-6 months and the decision can be made then. Also a good indicator of asthma control is how often you need to use your short-acting beta agonist (rescue inhaler), albuterol. If you find you are using more than one canister/month, it usually means the asthma is not under control. If you are awkened at night frequently this is another sign of uncontrolled asthma. You should also have your peak flow meter to use as an indicator of how therapy is going. And don't worry if you have to continue taking the inhaled corticosteroids. Remember like Bozz said, asthma is an inflammatory condition. The best thing to do is keep the inflammation under control. If left untreated, the chronic inflammation can lead to changes in the lining of the airways; hypertrophy and hyperplasia of the smooth muscle, increase airway wall thickness, and mucous gland hypertrophy and mucus hypersecretion. And the best way to treat this is with inhaled corticosteroids. The one good thing about asthma is that it IS reversible. But the point to take home is that asthma needs to be kept under control. You don't want to go back and be put on oral corticos again. And do things to minimize whatever triggers your asthma. If you have pets, keep them out of your sleeping room. You may need to buy the plastic encasements for your pillows/bed. Dust frequently and wash sheets every week in hot water. Yeah it's a pain in the ass but remember you are in control of your health. Keep regular appointments so you can reevaluate your treatment therapy.
Good luck! And don't worry about the Advair hindering your gains, because it won't. Systemic absorption is minimal and clinically insignificant.
Well said! Would make the NHLBI proud. As Ichabod stated avoiding triggers will play a big role in controlling your asthma. Again, allergy testing may be worth the time. I have seen patients identify triggers they had daily contact with (food, chemicals..), adjusting their daily activities made a big deal. In addition to keeping your sleeping area free of dust, another effort I have seen people have good results with is treating bedding, curtains and any other cloth where dust mites may live with anti-allergen spray. One in particular (I'm not sure of the name) it lasts three months, I think it is just denatured alcohol. My neice suffers from severe asthma and had been admitted to the hospital frequently. When her parents started to stay on top of dust and enclose/ treated her bedding, her symptoms improved dramatically.
gjohnson5
New member
Rogue47 said:
Good question I take this (the same dosage 250/50) and singular 10mg for my developing asthma and rhinitis/rhino-sinusitus (got 2 allergist who call it differnt things)
I have been having to stop and catch my breath during workout as I have been slacking on the 2
My real question is I believe I read ephedra is an asthma treatment. Being as I am, trying to get more cut anyway , is this a reasonable addition or replacement?
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