I broke out real bad halfway through and especially during PCT on my back and shoulders. I tried the B5 method for a couple months, but it did zip. I forget how much I was taking exactly, but it was a high number. I showered frequently, tried almost every OTC acne medication, etc. Nothing worked until I got on accutane. About 3 months in, I noticed a big difference and by month 6 the acne was virtually gone - some scarring remained, but tanning fixed that up. Side effects - chapped lips, dry skin and dry eyes. I haven't cycled since, and probably won't, so I don't know if accutane is a permanent solution or if one needs to run it everytime they cycle.