Oral winstrol makes two liver passes, while injecting is already in your blood supply so it only makes one liver pass. Simple logic says two passes on the liver means more taxing on your system. It is also less effective, which means you have to take more orally to equal the same amount injected. Again, using simple logic more winny means harder on your system. Also injecting is more of a sustained release, which is why one can get by on 50EOD. Seems standard oral dosage is 50mg, split up 2xdaily. So your liver gets hit hard 2xdaily plus having to make 2 passes, where as with IM it is hit gradually and only one pass. I am not saying injecting isn't hard on you, but it is the lesser of two evils.