Winny reduces progesterone aromatization during administration of Deca?

[tjbr]

I was just reading a post about deca and it reminded me of something I was told a few weeks ago.

A trusted source told me:

"Winny is molecularly structured in such a way that the drug will bind to the progesterone receptor but is NOT progestogenic, thus greatly reducing the chance for progesterone-related gyno."

I would double check this with someone in the Biology department but our conversations usually don't fall into oral designer steroids... only "theoretical testosterone levels"

 

[jondale123]

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The differential effects of stanozolol on human skin and synovial fibroblasts in vitro: DNA synthesis and receptor binding.Ellis AJ, Cawston TE, Mackie EJ. Rheumatology Research Unit, Addenbrooke's Hospital, Cambridge, UK. The anabolic steroid stanozolol stimulates the production of prostaglandin E2 (PGE2) and the matrix metalloproteinases collagenase and stromelysin in human skin fibroblasts but not in rheumatoid synovial fibroblasts. The basis for these differential responses was investigated at the levels of DNA synthesis and steroid receptor binding. Stanozolol inhibited fibroblast growth factor (FGF) stimulated DNA synthesis in both the skin and synovial fibroblasts, showing that both cell types were capable of responding to the compound. Competitive binding assays indicated that stanozolol bound specifically to both the skin and synovial fibroblasts. Binding of stanozolol to both cell types could be partially displaced by progesterone, indicating that stanozolol binds to the progesterone receptor.
Immunocytochemical studies confirmed the presence of progesterone receptors on skin and synovial fibroblasts. However, progesterone failed to elicit any response with respect to collagenase production in either cell type. Nortestosterone, dexamethasone and 17 beta oestradiol had no effect on binding of stanozolol to either cell type. These results indicate that the inhibition of DNA synthesis by stanozolol is elicited through the progesterone receptor. The effects of stanozolol on collagenase and PGE2 production are mediated by a different receptor, present on skin but not synovial fibroblasts, and as yet unidentified.

PMID: 8079819 [PubMed indexed for MEDLINE]
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"The theory goes that Winny can bind and compete for a position at the progesterone receptor much like clomid of Nolvadex would at the estrogen receptor, thereby inhibiting progestagenic effects. Now, progesterone can aggravate estrogenic side-effects by agonizing estrogen and it does play a role in gyno.
We also discussed that certain steroids may indeed stimulate and act at the height of the progesterone receptor including nandrolone and Norethandrolone. These hormones are also altered by it inducing a decrease in libido and a sense of lethargy and such, and eventhough they aromatize in lesser rates than some other steroids, they show an equal capability to cause estrogenic side-effects, particularly when stacked with other aromatizable compounds. Now there is evidence that Winny does indeed bind to the progesterone receptor1 and its users do not indicate the normal characteristics of progesterone stimulation, which bodes well for these anti-progestagenic properties. There is also some clinical data that it does aid in symptoms that require progesterone suppression2. Much in the way danazol was also successfully used. The one thing we shouldn't lose sight of however is in what rate it binds to the progesterone reception. There is no data on this. For all we know it couldn't bind strong enough to compete with nandrolone or norethandrolone. So its not wise to state that Winny is an anti-progestagin per se, but it does make Winny a good match for these products in stacks in any case."

 

[Nelson Montana]

As far back as the 70's guys used winny to counteract deca dick.

 

[cop]

what about anavar?? would it do the same???

 

[jondale123]

what about anavar?? would it do the same???

nope not that i know of

 

[ALIN]

I was just reading a post about deca and it reminded me of something I was told a few weeks ago.

A trusted source told me:

"Winny is molecularly structured in such a way that the drug will bind to the progesterone receptor but is NOT progestogenic, thus greatly reducing the chance for progesterone-related gyno."

I would double check this with someone in the Biology department but our conversations usually don't fall into oral designer steroids... only "theoretical testosterone levels"

Thats always been the theory behind WINSTROL.

 

[RADAR]

what about anavar?? would it do the same???

No, as they are not the same

 

[tjbr]

Thanks for the input everyone.

 

[megadad]

Would it have the same effect for fina/tren dick?

 

[Ox-Sandra-Loan]

I wonder if the winstrol (being known for painful joints) would counteract the happy joints you get from deca? My current cycle included low dose deca (deca finished now, test and eq still going) and my knees have never been happier. On the other hand, the one time i tried winny, i had to stop after 2 weeks because i could barely work out from the joint pain.