No it isnt any harsher than running Test/Tren/Winny together which in my opinion is 50 times more harsh on the human body than running winny and var together for 6 weeks. personally I would do injectable winny and oral Var. But if you have to run them both as orals and you keep it at 6 weeks dude you will recover perfectly fine with no permanent damage done. Think of all the same people preaching about not taking two orals together that drink alcohol every weekend if not every day!. Alchol is fucking way worse on your liver whether you are on juice or not, drinking is way more harmful. So I say yes you would be fine doing them together both orals if you must. Again I stress that you should get the injectable winny. You dont want to stick yourself every day? i dont understand why you have to do the winny as orals? I have noticed the fat flying off my abs since I added the Anavar to my cycle. Winny and Var together is by far the most favorite cycle I have ever ran. Of course my diet and training are spot on as well as the cardio I am doing 6 days a week. I still notice the fat coming off the abs way quicker than when I had the same diet and training plan but was only using Winny without the Var. I can personally attest to Var attacking abdominal fat.
Here is some info I found online "Although Anavar is an oral steroid, and has been alpha-alkylated to survive oral ingestion and the first pass through the liver, it´s still relatively mild in that respect too..., the unique chemical configuration of oxandrolone both confers a resistance to liver metabolism as well as noticable anabolic activity. It would also appear that Anavar appears not to exhibit the serious hepatotoxic effects (jaundice, cholestatic hepatitis, peliosis hepatis, hyperplasias and neoplasms) typically attributed to the C17alpha-alkylated AASs. (17) Anavar has even been used successfully in some studies to heal cutaneous wounds (7), or to improve respiratory function (18). Both of these novel properties could make it a good choice for in-season use for boxers, Mixed Martial Arts competitors, and other such athletes.
Anavar and Fat Loss
Now here´s some interesting stuff for anyone interested primarily in the fat loss properties of this stuff: Anavar may be what we´d call a "fat-burning steroid". Abdominal and visceral fat were both reduced in one study when subjects in the low/normal natural testosterone range used anavar (4). In another study, appendicular, total, and trunk fat were all reduced with a relatively small dose of 20mgs/day (8), and no exercise. In addition, weight gained with ´var may be nearly permanent too. It might not be much, but you´ll stand a good chance of keeping most of it. In one study, subjects maintained their weight (re)gains from anavar for at least 6 months after cessation (2)! Concomitantly, in another study, Twelve weeks after discontinuing oxandrolone, 83% of the reductions in total, trunk, and extremity fat were also sustained (8)! If you´re regaining weight, Anavar will give you nearly permanent gains, and if you are trying to lose fat (and you keep your diet in check), the fat lost with Anavar is basically looks to be nearly permanent. Check this chart out:
Absolute change in total fat mass (A) and trunk fat (B) by dual-energy X-ray absorptiometry from baseline to study week 12 (solid bars) and from baseline to study week 24 (open bars) in the placebo (n = 12) and the oxandrolone (n = 20) study groups. Values are means ± SE. *Significant decrease from baseline, P < 0.001. Significant difference between study groups for change in fat mass from 0 to 12 wk, P < 0.001. (15)(8)