Why Nolvadex?

[Smokescreen]

yo carth... just curious... why run aromasin year round if on just a HRT dose of test? it would make more sense to me to lower the HRT dose to a point that you dont get sides...

with that said, screw nolva.... i would rather stop cold turkey...

As I got older, I started to aromatize much more easily. Not sure why. I'm 34.

 

[Smokescreen]

Doesn't Nolva make HCG work better? Isn't there a drug that supposed to make the leydig cells more sensitive. Thus making HCG work better?

 

[Sub-Zero]

During a cycle you should always use AI instead of SERMs. Prolonged use of SERMs may have adverse effects as libido problems among others.

In PCT you should always use SERMs. When an AI is discontinued it may cause a rebound effect. If you use e.g. aromasin in PCT, you should use a SERM for at least 3 weeks after you stopped aromasin[/QUOTE]

is this true?

bump - im hoping someone could give me input, my original plan for the rest of pct was to extend my aromisin 5-7 days AFTER i stopped the nolva, but i will discontinue aromasin NOW, and taper off the nolva when im done if what this dude said was true....

any input?

 

[Sub-Zero]

anyone??

 

[pdaddyII]

bump - im hoping someone could give me input, my original plan for the rest of pct was to extend my aromisin 5-7 days AFTER i stopped the nolva, but i will discontinue aromasin NOW, and taper off the nolva when im done if what this dude said was true....

any input?

Yea I would like to know the answer to this as well.

 

[Smokescreen]

Hey. Don't ignore my last post.guys. lol

 

[Hexagon]

I will have to retract my claims that Aromasin causes a rebound effect.

The steroidal inactivator, exemestane, has a structure very similar to androgen, to androstenedione[...]

The nonsteroidal inhibitors have a mechanism of action that is distinctively different. It blocks cytochrome P450 binding to the substrate on the aromatase inhibitor, but it binds irreversibly. Does that mean anything clinically? I think at this point we don't know for sure, but based on the data presented looking at the aromatase enzyme activity, when you stop a steroidal inhibitor you immediately get a rebound effect of the aromatase enzyme.

In contrast, with exemestane, the steroidal inactivator that binds irreversibly to the enzyme, and when you stop it you have persistent low levels of aromatase.

Implications of Anti-Aromatase Structural Differences