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A lot of attention is paid to estrogen when on a steroid cycle and often a S.E.R.M. (Selective Estrogen Receptor Modulator) is used to combat gyno or for PCT.
Well, two anabolic compounds we often use (nandrolone and trenbolone) are both progestins that can cause or aggrevate gyno through stimulation of the progesterone receptors. Stimulation of the progesterone receptors also leads to an increase in prolactin which causes lactation, saps sex drive and prolongs recovery post-cycle. A dopamine agonist (such as bromocryptine, cabergoline, or selegiline) is usually suggested as an adjuct to a nandrolone or trenbolone cycle to reduce prolactin.
However, Selective Progesterone Receptor Modulators do exist and could be used to block progesterone receptors to combat gyno and prevent the increase in prolactin from occuring in the first place.
Asoprisnil is a SPRM that is used in the treatment of breast cancer that should be great at combatting progesterone gyno.
Additionally, Mifepristone (the morning after pill which is a 19 nor testosterone derivative) is a competitive progesterone receptor antagonist which will block progesterone receptors and combat the side effects of nandrolone and trenbolone.
And since progestins and prolactin will delay recovery of the HPTA, these compounds should be beneficial in PCT as well.
Is this an idea whose time has just not yet come or are there valid reasons why these drugs have not caught on in our world?
Well, two anabolic compounds we often use (nandrolone and trenbolone) are both progestins that can cause or aggrevate gyno through stimulation of the progesterone receptors. Stimulation of the progesterone receptors also leads to an increase in prolactin which causes lactation, saps sex drive and prolongs recovery post-cycle. A dopamine agonist (such as bromocryptine, cabergoline, or selegiline) is usually suggested as an adjuct to a nandrolone or trenbolone cycle to reduce prolactin.
However, Selective Progesterone Receptor Modulators do exist and could be used to block progesterone receptors to combat gyno and prevent the increase in prolactin from occuring in the first place.
Asoprisnil is a SPRM that is used in the treatment of breast cancer that should be great at combatting progesterone gyno.
Additionally, Mifepristone (the morning after pill which is a 19 nor testosterone derivative) is a competitive progesterone receptor antagonist which will block progesterone receptors and combat the side effects of nandrolone and trenbolone.
And since progestins and prolactin will delay recovery of the HPTA, these compounds should be beneficial in PCT as well.
Is this an idea whose time has just not yet come or are there valid reasons why these drugs have not caught on in our world?
