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Why is it that after starting a cycle, at about week 6-8...no more gains? You some how maintain while on gear going into the 10 and on week but no more gains. Why?
Why does gear stop working after a while?
- Thread starter Smokescreen
- Start date
theoak01
New member
I think your body just adapts to the new levels of hormones in your body,kinda like when it starts to get hard to add weight naturally ,I prefer longer cycles though because I feel it helps me maintain alot longer than if I go on for say 8 weeks and come off without giving my body a chance to get use to the new weight.
just my take on this anyway
just my take on this anyway
Von Zipperr
New member
it makes no sense what some people say on here, it gets me so confused. "Test will kick in around week 4", "Gains usually stop around week 6" I believe after week 4 till 12 gains just get better.
mrflexdiesel
New member
A majority of drugs taken have a action/reaction period. Times are different depending on the compound taken, but steroids and other performance enhancers tend to go problem free for about 2-4 weeks before other factors in your body start to react to the newly acquired levels of hormones or what not. Your body will attempt to stay in a state of homeostasis so if your testosterone levels are jacked after awhile your body will try and compensate for those high levels by also increasing your estrogen and cortisol levels. Both of these levels if not kept in check will dramatically reduce the amount of gains that can be made. Beyond at, if these levels are also not kept in check towards the end of your cycle and post-cycle you are even worse yet bound to lose alot of the gains you made during your cycle, because after the exogenous testosterone is discontinued your body's normal production is quite low to even non-existent, and estrogen and cortisol levels will remain high if not even bounce higher for awhile.
calveless wonder
New member
mrflexdiesel said:
makes sense...but what's the best way to keep cortisol levels down aside from taking another AAS?
recptors down-regulation..........which mean a decrease in the cells drug recptors, becuase of the extra drug in the body. you can solve the problem with upping the drug dose. that dosent mean than people with many cycles will not get results from low doses. the body up-regulat receptors and bring body to homeostasis after you stop taking the drug or AAS in this case.
that dosent mean that the all drugs lose it effects by time, some steroids take some time to give its effect in body., when the steroid bind to a receptor inside the cell it affects the gene transcription and translation in body to activate a kinase, utilzing proteins. this is a slow process whch take time. that why some aas is said to take an effect after 4-5 weeks.
that dosent mean that the all drugs lose it effects by time, some steroids take some time to give its effect in body., when the steroid bind to a receptor inside the cell it affects the gene transcription and translation in body to activate a kinase, utilzing proteins. this is a slow process whch take time. that why some aas is said to take an effect after 4-5 weeks.
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GoldenDelicious
New member
mmm dont agree with the cortisol angle
could be anything. just off the top of my head sort of thing:
negative feedback somewhere along the growth initiation/propagation cascade, whether at the receptor level or way further down the line before protein synthesis
some sort of consumptive deficit, ie using up your bodys stores of some needed cofactor, reagent or whatever, and not being able to replenish it
changes in distribution over time- there is nothing to say taht the distribution of the drug in the tissues- particularly the tissue containing the site of drug action- will stay the same. maybe it changes in such a way as to retard growth
some sort of metabolite produced, or some other hormone negating growth produced. yes teh cortisol argument fits in here, but the reason i disagreed with it earlier is beacuse i havnt heard of high cortisol being associated with AAS use per se
also other growth hormone/factor production may be inhibited/retarded
or it could come down to other factors like: people just stop eating enough to maintain growth, get burnt out at the gym without realising it....
or it could be all of the above. for all we know the very hypothesis is bullshit because the effect we are talking about (decreasing gains post week 8) might not actually occur in the first place (at least, it doesnt for everyone, of that i am convinced) as well as a few otehr inter-individual variance factors. people arent all the same. different aspects may manifest differently.
who knows.
could be anything. just off the top of my head sort of thing:
negative feedback somewhere along the growth initiation/propagation cascade, whether at the receptor level or way further down the line before protein synthesis
some sort of consumptive deficit, ie using up your bodys stores of some needed cofactor, reagent or whatever, and not being able to replenish it
changes in distribution over time- there is nothing to say taht the distribution of the drug in the tissues- particularly the tissue containing the site of drug action- will stay the same. maybe it changes in such a way as to retard growth
some sort of metabolite produced, or some other hormone negating growth produced. yes teh cortisol argument fits in here, but the reason i disagreed with it earlier is beacuse i havnt heard of high cortisol being associated with AAS use per se
also other growth hormone/factor production may be inhibited/retarded
or it could come down to other factors like: people just stop eating enough to maintain growth, get burnt out at the gym without realising it....
or it could be all of the above. for all we know the very hypothesis is bullshit because the effect we are talking about (decreasing gains post week 8) might not actually occur in the first place (at least, it doesnt for everyone, of that i am convinced) as well as a few otehr inter-individual variance factors. people arent all the same. different aspects may manifest differently.
who knows.
GoldenDelicious said:
actually it is the negative feedback mechanism. the master gland (hypothalamus) will detect the excess drug in the body, so it will reduces its LRH which effect the pituitary gland (Luteinizing hormone), then medulla cortex and gonads to reduce its androgen production or its androgen sensitivity through receptors down regulation.
Hormone secretion is controlled by three major types of inputs to endocrine cells
-Changes in the plasma concentrations of mineral ions or organic nutrients
-Neurotransmitters released from neurons impinging on the endocrine cell
-Another hormone or neurohormone acting on the endocrine cell
