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what is your aromatase inhibitor of choice?
- Thread starter EvilGenius989
- Start date
A
Anthony Roberts
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mm107 said:
As am I.
A
Anthony Roberts
Guest
Here's a study I posted on ATD (AIFM), deleted by Macro. Whoops! It looks like ATD/AIFM works by preventing test from binding to Androgen Receptors!
Effects of ATD on male sexual behavior and androgen receptor binding: a reexamination of the aromatization hypothesis.
Kaplan ME, McGinnis MY.
Department of Anatomy, Mount Sinai School of Medicine, CUNY, New York 10029.
The aromatization hypothesis asserts that testosterone (T) must be aromatized to estradiol (E2) to activate copulatory behavior in the male rat. In support of this hypothesis, the aromatization inhibitor, ATD, has been found to suppress male sexual behavior in T-treated rats. In our experiment, we first replicated this finding by peripherally injecting ATD (15 mg/day) or propylene glycol into T-treated (two 10-mm Silastic capsules) or control castrated male rats. In a second experiment, we bilaterally implanted either ATD-filled or blank cannulae into the medial preoptic area (MPOA) of either T-treated or control castrated male rats. With this more local distribution of ATD, a lesser decline in sexual behavior was found, suggesting that other brain areas are involved in the neurohormonal activation of copulatory behavior in the male rat. To determine whether in vivo ATD interacts with androgen or estrogen receptors, we conducted cell nuclear androgen and estrogen receptor binding assays of hypothalamus, preoptic area, amygdala, and septum following treatment with the combinations of systemic T alone. ATD plus T, ATD alone, and blank control. In all four brain areas binding of T to androgen receptors was significantly decreased in the presence of ATD, suggesting that ATD may act both as an androgen receptor blocker and as an aromatization inhibitor. Competitive binding studies indicated that ATD competes in vitro for cytosol androgen receptors, thus substantiating the in vivo antiandrogenic effects of ATD. Cell nuclear estrogen receptor binding was not significantly increased by exposure to T in the physiological range. No agonistic properties of ATD were observed either behaviorally or biochemically. Thus, an alternative explanation for the inhibitory effects of ATD on male sexual behavior is that ATD prevents T from binding to androgen receptors.
Oooopsie...it looks like AIFM is as good at blocking androgen receptors as it is as an AI. Can you say "no gains"...?
AIFM? LMFAO.
Effects of ATD on male sexual behavior and androgen receptor binding: a reexamination of the aromatization hypothesis.
Kaplan ME, McGinnis MY.
Department of Anatomy, Mount Sinai School of Medicine, CUNY, New York 10029.
The aromatization hypothesis asserts that testosterone (T) must be aromatized to estradiol (E2) to activate copulatory behavior in the male rat. In support of this hypothesis, the aromatization inhibitor, ATD, has been found to suppress male sexual behavior in T-treated rats. In our experiment, we first replicated this finding by peripherally injecting ATD (15 mg/day) or propylene glycol into T-treated (two 10-mm Silastic capsules) or control castrated male rats. In a second experiment, we bilaterally implanted either ATD-filled or blank cannulae into the medial preoptic area (MPOA) of either T-treated or control castrated male rats. With this more local distribution of ATD, a lesser decline in sexual behavior was found, suggesting that other brain areas are involved in the neurohormonal activation of copulatory behavior in the male rat. To determine whether in vivo ATD interacts with androgen or estrogen receptors, we conducted cell nuclear androgen and estrogen receptor binding assays of hypothalamus, preoptic area, amygdala, and septum following treatment with the combinations of systemic T alone. ATD plus T, ATD alone, and blank control. In all four brain areas binding of T to androgen receptors was significantly decreased in the presence of ATD, suggesting that ATD may act both as an androgen receptor blocker and as an aromatization inhibitor. Competitive binding studies indicated that ATD competes in vitro for cytosol androgen receptors, thus substantiating the in vivo antiandrogenic effects of ATD. Cell nuclear estrogen receptor binding was not significantly increased by exposure to T in the physiological range. No agonistic properties of ATD were observed either behaviorally or biochemically. Thus, an alternative explanation for the inhibitory effects of ATD on male sexual behavior is that ATD prevents T from binding to androgen receptors.
Oooopsie...it looks like AIFM is as good at blocking androgen receptors as it is as an AI. Can you say "no gains"...?
AIFM? LMFAO.
Anthony Roberts said:
GREAT POST! A lot of people aren't going to want to see this but everyone should.
worldclass
Banned
AR you've lost your mind. All the people using AIFM are not making gains? You're actually posting that? Don't you think there would be just a few posts about that.
You're extrapolating from a study done on castrated rats that has nothing to do with gains. Where does this study say that ATD inhibits T binding in the muscle?
If AIFM, like aromasin, inhibit T in the brain what would that have to do with binding to the AR in muscle?
You're comical when you let your hatred and ego interfere with your thought process.
You're extrapolating from a study done on castrated rats that has nothing to do with gains. Where does this study say that ATD inhibits T binding in the muscle?
If AIFM, like aromasin, inhibit T in the brain what would that have to do with binding to the AR in muscle?
You're comical when you let your hatred and ego interfere with your thought process.
worldclass said:
I think the better the word be "lesser gains." The study doesn't say how much T or e was supressed from the start -- just a lessened sexual behavior, which suggests lowered androgen. The thing that's good about animal studies is that is removes the placebo effect. You don't have rats saying things like "Yeah, I think it works, or "I feel it working" or " I think it made my dick grow." Then again, they didn't lop off the little bastards balls and see what actually went on in this study, it was purely observational. At any rate, any way you slice it, lessened sexual activity reads BAD in my book.
worldclass
Banned
Nelson, all AI's decrease libido at high doses. Which is what they used. High doses.
AR knows that. He's just making things up in head and applying studies unrelated to the use of the material to make a point. Which clearly, in this case, is wrong.
AR knows that. He's just making things up in head and applying studies unrelated to the use of the material to make a point. Which clearly, in this case, is wrong.
ALL aromatase inhibitors affects sexual behaviour because of suppression of Estrogen. All steroidal AI's have some affinity for the AR.
in high enough concentrations ATD and aromasin will displace test from the AR, though in high enough concentration test will displace estrogen from the ER. its faulty logic.
in high enough concentrations ATD and aromasin will displace test from the AR, though in high enough concentration test will displace estrogen from the ER. its faulty logic.
A
Anthony Roberts
Guest
MMM....I can taste the Kool-aid Macro is serving you guys right now. I would bet any amount of money "your" replies are coming straight from that fat fuck.
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