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"Too much testosterone kills brain cells "
- Thread starter Golddoor
- Start date
T
T-Matt
Guest
Ohhhhhhhhhhhhhhhhhhhhh.. so that explains why George Dub-ya is so dumb.. Too much testosterone.. whudda thunk that?!?!?
T-Matt
T-Matt
chazk
New member
KD1 said:
Thats becuase the men were trying to invent things to impress the girls so they would get laid.
Some where a cave man invented fire becuase he thought if he could keep his cave warm the chicks would dig it and hang out in his cave and he might be able to nail a little ass .
I'm sure the invention of the wheel was similar a nerdy caveman that wasnt getting laid was jealous and tried to roll a rock onto the bigger caveman that was fucking all the chicks and kill him so he might get a chance at fucking some of the girls.
Even bill gates was a fucking nerd a teckie junkie that could not get laid so he invented a program that runs the world so he could finally get a piece of the pussy pie.
T
T-Matt
Guest
chazk said:
Exactly..
Same reason we all do 5 extra minutes of cardio at a 15% higher intensity and 2 more reps on every exercise... It's that pussy factor.. YOu either have the drive for it or you don't.. Those who don't have the drive just shrivel up and die with their dicks in their hands wondering wtf just happened..
T-Matt
LOL.....This is the biggest load of Horseshit i've seen in awhile.
Jesus....I don't know how I got through all them Biochem classes while on test. Shit, imagine how much smarter I would have been if I didn't use.
LOL @ Lanky.....Your post made me laugh so hard. I can totally relate on the "text book smart guy" conversator = hardly any pussy.
If you do not have a sense of humor and can't fuck around at times, women will look right past ya.
BMJ
Jesus....I don't know how I got through all them Biochem classes while on test. Shit, imagine how much smarter I would have been if I didn't use.
LOL @ Lanky.....Your post made me laugh so hard. I can totally relate on the "text book smart guy" conversator = hardly any pussy.
If you do not have a sense of humor and can't fuck around at times, women will look right past ya.
BMJ
Well, here is the study that was used to come up with the conclusion that "Too much testosterone kills brain cells."
http://www.jbc.org/cgi/content/abst...INDEX=0&sortspec=relevance&resourcetype=HWCIT
J. Biol. Chem., Vol. 281, Issue 35, 25492-25501, September 1, 2006
"Elevated Testosterone Induces Apoptosis in Neuronal Cells*"
Manuel Estrada12, Anurag Varshney1, and Barbara E. Ehrlich3
From the Departments of Pharmacology and Cellular and Molecular Physiology, Yale University, New Haven, Connecticut 06520
Testosterone plays a crucial role in neuronal function, but elevated concentrations can have deleterious effects. Here we show that supraphysiological levels of testosterone (micromolar range) initiate the apoptotic cascade. We used three criteria, annexin V labeling, caspase activity, and DNA fragmentation, to determine that apoptotic pathways were activated by testosterone. Micromolar, but not nanomolar, testosterone concentrations increased the response in all three assays of apoptosis. In addition, testosterone induced different concentration-dependent Ca2+ signaling patterns: at low concentrations of testosterone (100 nM), Ca2+ oscillations were produced, whereas high concentrations (1-10 µM) induced a sustained Ca2+ increase. Elevated testosterone concentrations increase cell death, and this effect was abolished in the presence of either inhibitors of caspases or the inositol 1,4,5-trisphosphate receptor (InsP3R)-mediated Ca2+ release. Knockdown of InsP3R type 1 with specific small interfering RNA also abolished the testosterone-induced cell death and the prolonged Ca2+ signals. In contrast, knockdown of InsP3R type 3 modified neither the apoptotic response nor the Ca2+ signals. These results support our hypothesis that elevated testosterone alters InsP3R type 1-mediated intracellular Ca2+ signaling and that the prolonged Ca2+ signals lead to apoptotic cell death. These effects of testosterone on neurons will have long term effects on brain function.
--------------------------------------------------------------------------------
Received for publication, April 4, 2006 , and in revised form, June 20, 2006.
* This work was supported by National Institutes of Health Grants GM63496 and DK61747 (to B. E. E.), and FONDECYT Grant 1060077 (to M. E.), and a National Kidney Foundation postdoctoral fellowship (to A. V.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
1 These authors contributed equally to this work.
2 Present address: Programa de Fisiología y Biofísica, ICBM, Facultad de Medicina, Universidad de Chile, Correo 7, Santiago, Chile. Tel.: 56-2-9786272; Fax: 56-2-7776916; E-mail: [email protected].
3 To whom correspondence should be addressed: Dept. of Pharmacology, Yale University, 333 Cedar St., New Haven, CT 06520-8066. Tel.: 203-737-1158; Fax: 203-737-2027; E-mail: [email protected].
BMJ
http://www.jbc.org/cgi/content/abst...INDEX=0&sortspec=relevance&resourcetype=HWCIT
J. Biol. Chem., Vol. 281, Issue 35, 25492-25501, September 1, 2006
"Elevated Testosterone Induces Apoptosis in Neuronal Cells*"
Manuel Estrada12, Anurag Varshney1, and Barbara E. Ehrlich3
From the Departments of Pharmacology and Cellular and Molecular Physiology, Yale University, New Haven, Connecticut 06520
Testosterone plays a crucial role in neuronal function, but elevated concentrations can have deleterious effects. Here we show that supraphysiological levels of testosterone (micromolar range) initiate the apoptotic cascade. We used three criteria, annexin V labeling, caspase activity, and DNA fragmentation, to determine that apoptotic pathways were activated by testosterone. Micromolar, but not nanomolar, testosterone concentrations increased the response in all three assays of apoptosis. In addition, testosterone induced different concentration-dependent Ca2+ signaling patterns: at low concentrations of testosterone (100 nM), Ca2+ oscillations were produced, whereas high concentrations (1-10 µM) induced a sustained Ca2+ increase. Elevated testosterone concentrations increase cell death, and this effect was abolished in the presence of either inhibitors of caspases or the inositol 1,4,5-trisphosphate receptor (InsP3R)-mediated Ca2+ release. Knockdown of InsP3R type 1 with specific small interfering RNA also abolished the testosterone-induced cell death and the prolonged Ca2+ signals. In contrast, knockdown of InsP3R type 3 modified neither the apoptotic response nor the Ca2+ signals. These results support our hypothesis that elevated testosterone alters InsP3R type 1-mediated intracellular Ca2+ signaling and that the prolonged Ca2+ signals lead to apoptotic cell death. These effects of testosterone on neurons will have long term effects on brain function.
--------------------------------------------------------------------------------
Received for publication, April 4, 2006 , and in revised form, June 20, 2006.
* This work was supported by National Institutes of Health Grants GM63496 and DK61747 (to B. E. E.), and FONDECYT Grant 1060077 (to M. E.), and a National Kidney Foundation postdoctoral fellowship (to A. V.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
1 These authors contributed equally to this work.
2 Present address: Programa de Fisiología y Biofísica, ICBM, Facultad de Medicina, Universidad de Chile, Correo 7, Santiago, Chile. Tel.: 56-2-9786272; Fax: 56-2-7776916; E-mail: [email protected].
3 To whom correspondence should be addressed: Dept. of Pharmacology, Yale University, 333 Cedar St., New Haven, CT 06520-8066. Tel.: 203-737-1158; Fax: 203-737-2027; E-mail: [email protected].
BMJ
Skallagrimson
New member
I worried a little bit when I first read this, but then I realized I have no problem killing 20 beers in a night, and I'm pretty sure that'll do it. Like Nietzsche said (probably after comming off a cycle), "If you feel guilty about something, turn around and do something twice as bad. Then the first thing will seem like nothing."
