studies?...... i think looking at a true natty bodybuilder versus mr olympia competition's will surely give a real scene. i can tell you when i am all natural, i bust my ass trying to keep my self at 187 and thats with a little higher body fat. I eat my 8 meals a day and do whatever i can to keep the size and strength i gained (except my lower body, that is always strong and just gets stronger) now i am on cycle, 194 with a lower bodyfat and i can screw off on the diet when i feel like it. i can say i have never in my life ever weighed over 195. even on my deca cycle with all the water weight i got to 195. right now take 500mg test and 400mg primo, i can say 195 will not be broken by the end of this cycle. genetic limit, and a limit as too hold much i can hold while still being a functional person is very real for me. i am also a verry thin framed person to start with.
throgh my experience i say yes, your frame can hold x and then no more.