Tbol and water

[mendo]

OK...I've seen a ton of Tbol threads lately...but there is something I haven't seen mentioned. WATER INTAKE. I'm not sure if the other Tbol guys on here have experinced this, but Tbol really puts a strain on your kidneys. I have mentioned in a few threads that I had zero sides on Tbol...well that was while drinking around 2 gallons of water each day! If your water intake is not high you may get lower back pain. It happened to me a few times toward the end of my last Tbol cycle, and I just thought it was back pumps like Dbol (thats what it felt like to me). But after some research I noticed that it only happened when my water intake wasn't high.

This is because the metabolites from Tbol are mainly removed by the kidneys...not the liver. I've seen this posted a few times, and they mention it...


[The pharmacokinetics of Oral-Turinabol in humans]

[Article in German]

Schumann W.

Institut fur Mikrobiologie und experimentelle Therapie (ZIMET), Jena.

Disposition and excretion of the anabolic steroid Oral-Turinabol (1;4-chloro-17 alpha-methyl-androsta-1,4-diene-17 beta-hydroxy-3-one) were investigated in male volunteers. Following single p.o. and i.v. administration of the tritium-labelled compound the plasma concentration courses of total radioactivity (1 and 1-metabolites) and of the unchanged parent drug as well as the urinary excretion were estimated. From these data model independent pharmacokinetic parameters based on statistical moments were calculated. 1 is almost completely absorbed after p.o. administration of 10 mg per volunteer. Peak concentrations of total radioactivity and of 1 in plasma were reached about 3 h p.a. Irregularities observed in the plasma level profile following both p.o. and i.v. administration of 1 are due to a marked enterohepatic circulation. Orally given 1 is subject to a first-pass effect, resulting in a diminished systematic availability. The AUC-ratio of the unchanged drug and the total radioactivity of 1 : 13 shows the predominance of metabolites in plasma. After i.v. administration the disposition of unchanged 1 was found biphasically with a terminal half-life of 16 h. 1 and its metabolites are preferentially excreted via the kidneys. The urinary total radioactivity represented about 60% of the dose following both administrations. Due to its affinity to SHBG 1 is able to compete for the protein binding of testosterone, resulting in an increased plasma level of non protein-bound testosterone.


Also, it is a 17aa oral...so the liver still takes a hit as well.

 

[sparetire]

how much tbol did you take daily (40? 20?) and for how many weeks?

just curious..i've been planning on running tbol at the beginning of my next cycle..

and did you bloat at all and how was your gains?

 

[mendo]

how much tbol did you take daily (40? 20?) and for how many weeks?

just curious..i've been planning on running tbol at the beginning of my next cycle..

and did you bloat at all and how was your gains?

I run 60 mg/day for around 5 weeks (I end it when I notice the gains have stopped for a few days). I've done 2 cycles like that....and I still have enough to run 4 more. I take 4 weeks off in between. Zero bloat...or other sides. First cycle, I gained 12 lbs...second I gained 9 lbs. My BF was pretty much unchanged....maybe a slight loss. So far I've kept around 15 lbs total from both and I'm due to start my next one in 4 days. Outstanding in my opinion.

 

[sparetire]

okay, i'm able to order enough for 40mg/day for 6 weeks. I can always front load the first week with 60mg/day and then 40mg/day for 5 weeks.. what else are/were you running during your cycle?

I was thinking of eq 1-10
tbol 40 1-6
masteron 6-12

i have test, but i'm not sure if i'll throw it in yet..i ran a semi-high level (700) and i had horrible side effects with acne and headaches etc..so if i run it in this cycle i have test prop and test which is 200enth/200 cyp ..

 

[BigMike]

I just finished a Tbol cycle 50mg/day for 10 weeks with no sides at all, kept water intake at least 1.5-2 gallons a day. About the only side I had was a gain of about 15 LBM. I am taking another four weeks off then hitting another ten weeker.

 

[mendo]

okay, i'm able to order enough for 40mg/day for 6 weeks. I can always front load the first week with 60mg/day and then 40mg/day for 5 weeks.. what else are/were you running during your cycle?

I was thinking of eq 1-10
tbol 40 1-6
masteron 6-12

i have test, but i'm not sure if i'll throw it in yet..i ran a semi-high level (700) and i had horrible side effects with acne and headaches etc..so if i run it in this cycle i have test prop and test which is 200enth/200 cyp ..

I ran 300 test e with it during the first one. The second was Tbol only. I hate the sides I get from test also, and I only ran it cause I was worried about libido issues without it. Turns out libido was fine without test...so now its Tbol only for me, for as long as these little short cycles keep working.

I'm not a stack expert, but here's my take:

1) Your eq seems a little short to me, maybe run it for 14 weeks (takes awhile to really kick in)
2) In my experience Tbol is really only good for a little over 3 weeks...I always try to push it, but I would be surprised if you see gains for 6 weeks
3) I've never tried masteron...but I love winny to finish up a cycle

maybe something like this:
eq 1-14 or more
tbol 1-4
winny or masteron 6-14
test 1-14 (?)

 

[mendo]

I just finished a Tbol cycle 50mg/day for 10 weeks with no sides at all, kept water intake at least 1.5-2 gallons a day. About the only side I had was a gain of about 15 LBM. I am taking another four weeks off then hitting another ten weeker.

Was it Tbol only, or did you stack it? Did you notice any change in your strength or gains after the first few weeks? Just curious..

 

[BigMike]

Yes, Tbol only along with creatine, protein and multivitamins. Strength gains were noticed in the second week and continued until around week 8. Just finished PCT with just the standard clomid dosing. I have run var, winny, and test befor but my goals have changed over the years and for me Tbol is my choice for the time being.

 

[mendo]

I'm starting to think its a good idea to take cranberry extracts or juice with a Tbol cycle for the kidneys...in addition to milkthistle/Tylers liver detox.

 

[stuck]

I'm starting to think its a good idea to take cranberry extracts or juice with a Tbol cycle for the kidneys...in addition to milkthistle/Tylers liver detox.

Tbol is a 17aa, so that would be a good idea.

 

[mendo]

Tbol is a 17aa, so that would be a good idea.

Are you saying that all 17aas put this kind of burdon on the kidneys? I've never noticed it with winny... And the main supp I hear mentioned to go along with orals is milkthistle...not cran. Is cranberry common knowledge for oral cycles and I just missed it?

 

[stuck]

Are you saying that all 17aas put this kind of burdon on the kidneys? I've never noticed it with winny... And the main supp I hear mentioned to go along with orals is milkthistle...not cran. Is cranberry common knowledge for oral cycles and I just missed it?

Ah for some reason I missed "kidneys" and saw "liver". Apologies, haven't finished my coffee yet.

I still run it with tylers tho.

 

[mendo]

Bump for other Tbol user's thoughts...

 

[Bruce]

pure cranberry juice is my saviour, i can chug a whole thing in a day. clears out everything. thanks mendo great thread

 

[smaretick]

I def ran Tyler's & Cranberry extract with tbol & didn't have any probs.

 

[mendo]

Is it just me...or does the last sentence in that abstract seem to imply an increase in free testosterone from Tbol... My guess is that would go down once natty test starts to get shut down.

 

[Retabolil2]

Bump for other Tbol user's thoughts...

Well I`ve done 150mg tbol a day for 3 weeks and 120mg for 6weeks and didnt notice any problems with my kidneys, didnt take any extra water as I dont have enough time to watch my daily water intake...
Had problems with sex drive but its probably since I`ve stopped taking tren...

 

[mendo]

Well I`ve done 150mg tbol a day for 3 weeks and 120mg for 6weeks and didnt notice any problems with my kidneys, didnt take any extra water as I dont have enough time to watch my daily water intake...
Had problems with sex drive but its probably since I`ve stopped taking tren...

Wow 150mg, you're an animals bro! Out of curiousity, about how much water did you drink on cycle? On your 6 weeker did your gains continue the whole time, and what were your stacks like?

 

[PussyWhipped]

[The pharmacokinetics of Oral-Turinabol in humans]
Due to its affinity to SHBG 1 is able to compete for the protein binding of testosterone, resulting in an increased plasma level of non protein-bound testosterone..

This is an interesting little side note. basically saying that it increases levels of Free Test (unbound test) similar to proviron or avena sativa. This would help explain the anedotal reports of increased libido/performance when on tbol even when not also using test.

It also probably means that Tbol would have increased effectiveness in older men since a higher percentage of their test is bound.

can any of the chem-heads comment?