stored in hot temperature

[Laser0001]

My buddy brought me hcg today and the only place I could
keep it was in my car the temperature was nearly 100 today
will it still be good?

 

[presguy]

how long was it in there?

 

[Generic MALE]

Mixed or not? The unmixed for is much more stable.

One cheap way to see if it has ANY potency left is to get a home pregnancy kit and mix it and squirt some on the pregnancy test. If it still is an intact complete peptide protein (not denatured by heat) then it should trigger a reaction positive for pregnancy.


HGH is also really heat sensitive so they say. About 4 years ago I ordered chinese HGH and it was well over 100 degrees. I opened the container and dropped in a lab grade thermometer. I can't remember the exact temperature inside the box but it was way hotter than it was supposed to be. I used it and sent a sample to a med school lab that specializes in endocrinology and it came back as being very good. HGH is also a peptide protein and the heat did not denature it.

I had posted about this on an old (now defunct) bulletin board called THE ROCKS back then.

 

[Laser0001]

It isnt mixed and I dont need it for a while. Maybe I should get some more just in case. My wife will freak when I bring home the EPT. We have 6 kids and she has had 2 tubal ligations one didnt hold. Ill save this so she doesnt start acusing me

 

[Laser0001]

Generic Male. How about test, it gets a bit on the warm side where I store it?

 

[Stryker1992]

unmixed is fine, very stable.

 

[Generic MALE]

Sorry laser. I don't really know for 100% certainty. I have seen things regarding its boiling point, and pharm grade testo comes saying store in a cool place and is usually in amber colored bottles so it is protected from sunlight.... but then again I have heard some guys say they have actually cooked their testo in a stove to sterilize it or burn off some benzoyl alcohol, and grew huge on it. So I don't know for sure.

100 degrees is not that warm. It becomes 98 degrees when it goes in your body.

 

[Generic MALE]

It isnt mixed and I dont need it for a while. Maybe I should get some more just in case. My wife will freak when I bring home the EPT. We have 6 kids and she has had 2 tubal ligations one didnt hold. Ill save this so she doesnt start acusing me

Dude, what I think would freak her out is that you go into the bathroom by yourself and come back awhile later with a positive EPT test.

 

[Laser0001]

Thank You for your replies. I hope it does come back positive and
for fun I will show her.

 

[RADAR]

Dude, what I think would freak her out is that you go into the bathroom by yourself and come back awhile later with a positive EPT test.

I can see it now!!! Honey i'm pregnant!!! LOL!!!

BTW they're gonna have a grand ole time pulling that lil squirt outta the hole!


RADAR

 

[Dr. M]

How about test, it gets a bit on the warm side where I store it?

As a biochemist, I feel qualified to answer this question... hopefully you guys will agree.

Testosterone is a polycyclic organic compound which is extremely heat-stable. You could cook it in your oven for hours, especially if it was in solution such as it is in oil-based preparations, and it would still retain most, if not all, of its biological activity.

Proteins such as HCG, Insulin, etc. are governed by comparatively weak interactions such as hydrogen bonding, van der Waals forces, London Dispersion forces, and overall/relative hydropathy with respect to the solvent environment. The amino acids are strongly bound to the preceeding and succeeding residues

Steroids such as testosterone, methenolone, oxandrolone, etc. (anything you use as an anabolic, quite frankly) have a polycyclic organic structure which is governed by actual chemical bonds and very rigid stereochemico-energetic forces. It takes a lot more than a hot car to cause homolysis/heterolysis of these bonds and thus alter the structure of steroids.

Think of it this way if my biochem-babble is a little too over the top:
Proteins - the little piggies who built their houses out of straw or sticks.
Steroids - the little piggy who built his house out of brick and mortar, put up a security fence, and then barred his windows.

Now you can wreck the brick house, but it would take a lot more than a huff and a puff from the big bad wolf (warm car, oven, etc.). This isn't the case for the proteins, which can be denatured relatively easily, especially if they're in a low ionic strength buffer or are in especially low concentration.

Hope this helps!
-M

 

[Sigmund Roid]

Hi Dr. M

I found trenbolone to be very unstable by looking at the discoloration from light yellow to almost brown at room temperature over a period of 1 year when kept away from sun light and air. It must be caused by the unsaturated bonds in a row in the polycyclic structure. What do you think?

 

[Dr. M]

Hi Dr. M

I found trenbolone to be very unstable by looking at the discoloration from light yellow to almost brown at room temperature over a period of 1 year when kept away from sun light and air. It must be caused by the unsaturated bonds in a row in the polycyclic structure. What do you think?

Hi Sigmund -

I can definitely see a conjugated triene system such as trenbolone undergoing sigmatropic shifts along the pi-system... it's primed for a variety of hydride shifts and various other [1,x]-sigmatropics which could affect the light absorption properties of the molecule and thus change the colour. Since the shifts allowed for that sort of a system pretty much cover the entire spectrum of sigmatropic shifts (i.e. 4n thermally allowed antarafacial, 4n photochemically allowed suprafacial, 4n+2 thermally allowed suprafacial, 4n+2 photochemically allowed antarafacial), a lot of things could happen even in the absence of light - room temperature for a year can be enough for some of the possible [1,4], [1,5], [1,6] thermally allowed rearrangements to take place even in the absence of light energy.

Systems such as those in trenbolone can give rise to very interesting things, many of them spontaneous at body or room temperature, and can be quite important in vivo. Human synthesis of Vitamin D is a very important example of one such reaction, where UV light from the sun is used to initiate a single, high-energy photochemically allowed shift, which leads to a molecular configuration which is extremely suitable for a chain-reaction of shifts to create the finished VitD.

Interesting stuff - great question, Sig!
-M

 

[Dr. M]

Bump

Bump for Sigmund Roid

 

[Sigmund Roid]

Thanks for your long answer Dr. M.

When I saw the discoloration happen, I put my tren immediately in the freezer, well packed of course.

 

[Dr. M]

You're very welcome, Sig.

 

[liftsiron]

Good info Dr. M To answer the question at hand I would think that the hcg is still good and will be effective. HGH is more fragile and is destroyed by heat faster. The china HGH unreconstituted can only tolerate approx three days without refridgearation before it starts to degrade actual serno may be left for weeks even months at room temp. Igf-1 will degrade very quickly in warm temps as it is very unstable.