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have i understood wrong or anti estrogens can negatively influence fertility ?
Journal of Andrology, Vol. 26, No. 4, July/August 2005
Copyright © American Society of Andrology
the Stimulatory Role of Estrogen on Sperm Motility in the Male Golden Hamster (Mesocricetus auratus)
WANZHU JIN*,, KOJI Y. ARAI, GEN WATANABE*,, AKIRA K. SUZUKI, SHINJI TAKAHASHI|| AND KAZUYOSHI TAYA*,
From the * Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan; Laboratory of Veterinary Physiology and Department of Tissue Physiology, Tokyo University of Agriculture and Technology, Tokyo, Japan; and PM2.5/DEP Research Project, || Environmental Dioxin Project Group, National Institute for Environmental Studies, Ibaraki, Japan.
Correspondence to: Kazuyoshi Taya, DVM, PhD, Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwaicho, Fuchu, Tokyo 183-8509, Japan (e-mail: [email protected]).
Received for publication November 4, 2004; accepted for publication February 4, 2005.
To clarify the physiological roles of estrogens in the regulation of sperm motility in the golden hamster, two different approaches were used. In the first experiment, silastic tubes containing either low (low E2 group) or high (high E2 group) amount of estradiol-17ß were implanted (Exp 1). In the second experiment, male golden hamsters were actively immunized against estradiol-17ß (Exp 2). In Exp 1, all sperm motility parameters (including motility, straight velocity, curvilinear velocity, beat/cross frequency, and mean amplitude of lateral head displacement) were significantly increased except linear index in the high E2 group as compared with controls at 20 days after the treatment. In the high E2 group, plasma concentrations of luteinizing hormone (LH) significantly increased, whereas levels of circulating testosterone decreased significantly. Plasma concentrations of follicle-stimulating hormone (FSH) and immunoreactive inhibin were not affected by the treatment with estradiol-17ß. In the Exp 2, titer of circulating antibodies to estradiol-17ß consistently increased after the second immunization until the end of experiment (16 weeks). The sperm motility, straight velocity, and curvilinear velocity were significantly decreased after active immunization to estradiol-17ß. Concentrations of circulating LH and FSH were also decreased significantly by the treatment. In conclusion, the present study clearly demonstrated that estradiol-17ß has stimulatory effects on sperm motility and secretion of gonadotropin in the golden hamster, and has a suppressive effect on testosterone secretion. Further studies are required to reveal mechanisms responsible for these responses
Key words: Estrogen immunization, gonadotropin
http://www.andrologyjournal.org/cgi/content/full/26/4/478
Journal of Andrology, Vol. 26, No. 4, July/August 2005
Copyright © American Society of Andrology
the Stimulatory Role of Estrogen on Sperm Motility in the Male Golden Hamster (Mesocricetus auratus)
WANZHU JIN*,, KOJI Y. ARAI, GEN WATANABE*,, AKIRA K. SUZUKI, SHINJI TAKAHASHI|| AND KAZUYOSHI TAYA*,
From the * Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan; Laboratory of Veterinary Physiology and Department of Tissue Physiology, Tokyo University of Agriculture and Technology, Tokyo, Japan; and PM2.5/DEP Research Project, || Environmental Dioxin Project Group, National Institute for Environmental Studies, Ibaraki, Japan.
Correspondence to: Kazuyoshi Taya, DVM, PhD, Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwaicho, Fuchu, Tokyo 183-8509, Japan (e-mail: [email protected]).
Received for publication November 4, 2004; accepted for publication February 4, 2005.
To clarify the physiological roles of estrogens in the regulation of sperm motility in the golden hamster, two different approaches were used. In the first experiment, silastic tubes containing either low (low E2 group) or high (high E2 group) amount of estradiol-17ß were implanted (Exp 1). In the second experiment, male golden hamsters were actively immunized against estradiol-17ß (Exp 2). In Exp 1, all sperm motility parameters (including motility, straight velocity, curvilinear velocity, beat/cross frequency, and mean amplitude of lateral head displacement) were significantly increased except linear index in the high E2 group as compared with controls at 20 days after the treatment. In the high E2 group, plasma concentrations of luteinizing hormone (LH) significantly increased, whereas levels of circulating testosterone decreased significantly. Plasma concentrations of follicle-stimulating hormone (FSH) and immunoreactive inhibin were not affected by the treatment with estradiol-17ß. In the Exp 2, titer of circulating antibodies to estradiol-17ß consistently increased after the second immunization until the end of experiment (16 weeks). The sperm motility, straight velocity, and curvilinear velocity were significantly decreased after active immunization to estradiol-17ß. Concentrations of circulating LH and FSH were also decreased significantly by the treatment. In conclusion, the present study clearly demonstrated that estradiol-17ß has stimulatory effects on sperm motility and secretion of gonadotropin in the golden hamster, and has a suppressive effect on testosterone secretion. Further studies are required to reveal mechanisms responsible for these responses
Key words: Estrogen immunization, gonadotropin
http://www.andrologyjournal.org/cgi/content/full/26/4/478
