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Serotonin agonists for cutting?

B182

New member
here's some info regarding bromo for weightloss but being potentiated by serotonin agonists...which raises the question, what's a cheap, easily obtainable serrotonin agonist?


taken from http://www.pslgroup.com/dg/95e6.htm

"In one study, "Dopaminergic D1/D2 Synergism Reverses Obesity and Lipid Disorders in the Leptin-Deficient ob/ob Mouse," by E. Tozzo, et. al., Ergo Science researchers established that stimulation of two dopaminergic receptors produced a significant (between 50 and 60%) reduction in food intake, dramatic weight loss and a decrease in fat stores of 22-32% with no significant decrease in lean body (muscle) mass. This approach also improved glycemic control, reducing glucose 57% and insulin 50%, respectively. These effects were accomplished without the administration of exogenous leptin. In a second study, Ergo researchers found that timed administration of a dopamine agonist and a serotonin agonist reduced body fat 30-75% and body weight gain 40-60%. In this study, lean body mass was increased 5-17% confirming that the two drug regimen was able to reduce weight by selectively reducing body fat. Again, these reductions were accomplished without the administration of leptin. The selective reduction in body fat and preservation of lean body mass has significant implications for the treatment of human obesity as improvement in the lean-to-fat ratio is thought to be closely associated with a reduction in the cardiovascular risk factors resulting from chronic obesity."
 
I think your missing the point here. Note how both studies use some sort of dopaminergic agonist. It has long been known that Da activity significantly lowers appetite. This is how many prescription weight loss meds (like phentermine) work - they are mild Da agonists. On the other end of the spectrum, increased levels of serotonin are often associated with increased carbohydrate cravings. In fact the main complaint by patients on SSRIs (besides impotence) is weight gain.

Also keep in mind that any drug/substance that alters neurotransmitter levels is going to be regulated. IN the case of dopamine, these drugs are scheduled class-II.
 
icelandic,actually serotonin agonists may lower appetite.Remember,serotonin rises from carbmeals.Artificially high serotonin=reduced carb craving.
Many people on SSRI's report reduced appetite,myself included.
And they are frequently used for this purpose as well.
 
posthuman said:
icelandic,actually serotonin agonists may lower appetite.Remember,serotonin rises from carbmeals.Artificially high serotonin=reduced carb craving.
Many people on SSRI's report reduced appetite,myself included.
And they are frequently used for this purpose as well.

What??

SSRI's make you gain weight!! I gain 30lbs!

SSRI's dont increase serotonin, there make the the brain more receptive to it and increase the ability to use whats available!
 
What?? ...
Yup,you know how the appetite supressant fenluramine works?
Serotonin is intimately involved in satiety.
You DO know that Prozac is being used in obese patients to LOSE weight don't you?
 
post marketing effects are far and away associated more with weight gain more than loss.
True.My point was that serotonin is involved in satiety.Therefore using a serotonin agonist for weight loss is not a stretch by any means.
Look into sibutramine for example.

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7969665&dopt=Abstract High local levels of 5HT(serotonin) cause a reduction of appetite and a preference for protein, low levels the opposite. The main antagonistic system is noradrenergic. The drug d-fenfluramine mimics the effects of 5HT by releasing 5HT from serotoninergic nerve endings and inhibiting its neuronal re-uptake. Further experimental data prove that a high-carbohydrate, low-protein diet promotes uptake of serum tryptophan in the brain and its conversion into 5HT.
 
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