question for people with pharm/micro knowledge

[pharmguy]

(also posted on anabolic )

Why can't we just take 2 separate massive doses of antibiotics? Like 4000 mg tetracycline and again the next day another 4000 mgs, won't that wipe out your bacterial problem? why must it be spread out?

 

[Paulo]

Potentially because the body can only absord so much at one time.

 

[RADAR]

the exact same reason we cant take 2000mgs of aspirin all at once!

RADAR

 

[pharmguy]

the exact same reason we cant take 2000mgs of aspirin all at once!

RADAR

That is ridiculous......

No offense man, but the title of the post read, "for people with pharm/micro knowledge"

In a lab, when you do a (?) plate(I forget the name right now) It takes 1 dose to kill microbes.

Alternatively, there are other medications that can be taken in a massive dose, or spread out, IE: cortisone.

 

[atlantabiolab]

That is ridiculous......

Actually it is right to the point.

No offense man, but the title of the post read, "for people with pharm/micro knowledge"

In a lab, when you do a (?) plate(I forget the name right now) It takes 1 dose to kill microbes.

Are you talking about a Minimum Inhibitory Concentration Plate, where you look at the sensitivity of organisms to an antibiotic?

First problem is that in vitro does not correspond to in vivo; an agar plate cannot be hurt by an antibiotic, whereas the individual can be.

Antibiotics can cause serious side effects, such as renal damage, hearing loss, granulocytosis, death.

Alternatively, there are other medications that can be taken in a massive dose, or spread out, IE: cortisone.

In the case of cortisone the doses are different based on the manner of administration, i.e. injection or enteral, the former allowing for prolonged pharmacokinetics and the latter of shorter duration.

There are oral penicillins, which must be taken in multiple daily doses and then there are injectable penicillin preparations, which only require one initial dose, since the drug is slowly hydrolyzed and released from its depot.

 

[PatsFan34]

If I went to class or paid attention, I would've been able to answer this, oh well...GO PATRIOTS!!!

 

[Lao Tzu]

i think tetracycline causes damage to the ears in large doses, so thats one reason why you can't take that much tetracycline.

 

[BileStew]

the exact same reason we cant take 2000mgs of aspirin all at once!

RADAR

I do that all the time. I take 4 500mg at a clip.

 

[pharmguy]

Actually it is right to the point.



Are you talking about a Minimum Inhibitory Concentration Plate, where you look at the sensitivity of organisms to an antibiotic?

First problem is that in vitro does not correspond to in vivo; an agar plate cannot be hurt by an antibiotic, whereas the individual can be.

Antibiotics can cause serious side effects, such as renal damage, hearing loss, granulocytosis, death.

But my point was made, you can't just say"well can you take a bunch of aspirin? No!"





In the case of cortisone the doses are different based on the manner of administration, i.e. injection or enteral, the former allowing for prolonged pharmacokinetics and the latter of shorter duration.

There are oral penicillins, which must be taken in multiple daily doses and then there are injectable penicillin preparations, which only require one initial dose, since the drug is slowly hydrolyzed and released from its depot.

Thanks atlantabiolab, very well answered, karma

I do remember something about tetracycine cause hearing damage