freeze2000 said:
Thanks man, i got a question though. What properties does winstrol do to the body? It doesn't **** with your testosterone or anything, what does it exactly do? But ok, ill finish my test testosterone propionate in about 1-2 weeks then start on my PCT - post cycle therapy - - post cycle therapy - - post cycle therapy - - post cycle therapy - .
1st, you may to pm needto
--he will be able to walk you through a good p/c/t with the issues you have..and
2nd, if you want to know the Winstrol - stanozolol works--and are bored, read on:
Wnistrol (Stanozolol)
You can use Winstrol (Stanozolol) as either an oral or injectable, and get a very different set of effects from the same drug- depending on which route of administration you choose to utilize.The basics of Winstrol.Winstrol is a steroid derived from the base structure of Dihydrotestosterone (dihydrotestosterone). dihydrotestosterone is just testosterone which hasbeen 5alpha-reduced, meaning it has had the c4-5 double bond removed by two hydrogen atoms. This is very interesting from a chemical/biological standpoint. Once this bond is removed, testosterone has become dihydrotestosterone, and DHT is the body’s most potent androgen. DHT has a slew of beneficial effects which are more pronounced than the hormone it’s created outof. DHT is able to increase androgen receptor proliferation for almost 24 full hours (1) DHT also has profound effects onthe Central Nervous System (central nervous system), and this is why we often see profoundly increased aggression with athletes who are using DHT derivatives such as Masteron (which has a deceivingly low anabolic and androgenic rating). As an addedbenefit, DHT can not aromatize (convert via the aromatase enzyme) into estrogen. It’s also noteworthy that the injectableversion of Winstrol is actually the same exact thing as the oral- it’s just micronized Stanozolol powder suspended inwater (or sometimes oil). So what we have in Winstrol is DHT with two modifications- an added c17 methylation, and a very weird “pyrazol” group. The c17 methylation has been added in order to allow Winstrol to survive oral ingestion and the subsequent first passthrough the liver. The pyrazol group is a bit weirder- what this means to you and I is that it has another whole “ring”attached to the four ring Steran Nucleus of DHT. Take a look over at the lower left portion of the two molecules below,and you’ll notice that Winstrol has an added cyclopentane (5 sided) group (the pyrazol group) when we really take a look at Winstrol, the anabolic rating of this product is very high (320% that of testosterone) ascompared to its androgenic actions (30% of testosterone). Despite this, Winstrol is really a disappointing drug for sizegains. What we typically see with this stuff is some pretty decent strength gains and some nice fat loss if the user isn’t toosloppy with their diet. Not many people report huge weight gains off of Stanozolol. Although many drugs which bindtightly to the androgen receptor are suspected to exhibit their at least some of their lipolytic (fat-burning) effects throughreceptor binding affinity. The effects of androgens on the regulation of lipolysis in adipose precursor cells.(2), Winstrolremains a potent cutting drug, despite the fact that it has a relatively weak AR binding ability (3). What this tells us is thatthere’s some stuff going on with regards to Winstrol’s mechanism of action, which doesn’t involve androgen receptor mediated effects. Still, Winstrol is a very potent compound for enhancing protein synthesis (4-5 ) .As previously discussed, it’s derived from DHT, and DHT is known to have ant-estrogenic effects (6) and Winstrol itselfalso has anti-progestenic properties (in at least some cases, where it may "block" that receptor) (7). So I think it’s safe to say that some of the “hard” look you can get in your physique from Winstrol is because of it’s ability to inhibit estrogen and progesterone- known culprits in making a physique appear smooth. Unfortunately, since it is 17 alpha-alkylated, it is also liver toxic,especially more so when you inject it and it is subject to what is known as the “first pass” through the liver. The differencebetween taking oral vs. injectable Winstrol, even though it’s technically the same drug, is how and when your body metabolizes it. When you consume a drug orally, that drug is absorbed from the Gastrointestinal tract, where it then passes via the portal vein into the liver -where some drugs are metabolised. This “first pass” can mean that only a certain portion of the drug reaches your body’s blood stream. As previously discussed, a 17 alpha-alkylated has been attached to Winstrol toallow a sizeable portion to survive this metabolism.First pass metabolism can occur in both the gut and the liver, and where this happens can vary with different drugs. Firstpass metabolism actually occurs in your gut for some drugs and in the liver for others. Once it has been metabolized, it enters the bloodstream. It’s important to note that when a blood is metabolized in the Gastrointestinal tract, the bloodleaving the Gastrointestinal tract does not go right to the heart, but actually still passes through liver via the hepatic portalvein and then ultimately returns to circulation via the hepatic vein. The liver is your body’s filtration unit, and removeslarge quantities of nutrients, dangerous toxins (or fun toxins, depending on what they are) and other substances from theblood.So as you can see, when you take an oral steroid such as Winstrol, undergoes a first-pass metabolism in both theintestines as well as liver. Some drugs can be absorbed more or less totally intact, after only moderate metabolic activity,while some are absorbed only after very extensive metabolic activity. Once it is through this first pass, a given drug thencirculates in the blood until it is acquired by another tissue, such as skeletal muscle. Now, if the drug reaches the liveragain, it may undergo what is cleverly known as “second-pass” metabolism. Of course, in the case of Winstrol, aninjectable version is available, and when we compare the oral and injectable versions of Winstrol and their effects in yourbody, I think there’s some surprising differences. The injectable is (naturally) put right into your bloodstream and onlyundergoes the far less extensive second pass metabolism, while the oral must endure the gut and liver on it’s first passbefore ending up in circulation.Now, here’s the interesting part: When you inject Winstrol, instead of taking it orally, you actually get more nitrogenretention (4) (and hence we can infer, more new muscle tissue is being built). SO if you are trying to use Winstrol to buildnew muscle tissue, the injectable version is going to be far superior to the Oral version. However, there are someadvantages that the oral version has over the injectable, including a possible “synergy” with other drugs- but only(primarily) when taken orally. Enhanced Genetics Forum -
While in the liver, on it’s first pass, Winstrol is exposed to a variety of enzymes and proteins. To understand how apossible synergy between Winstrol and other steroids may be possible, a little background on Sex Hormone BindingGlobulin (sex hormone binding globulin ) is first necessary. For our purposes here, all we need to know is that sex hormone binding globulin is a glycoprotein producedin the liver, which binds to testosterone and makes it biologically unavailable to do all the things we want it to do- likebuilding muscle. It serves to transport testosterone throughout the body, but while it remains bound to testosterone, thetestosterone can not exert it’s anabolic effects. As you can surmise, a very large portion of the testosterone in your body is bound to sex hormone binding globulin . Wouldn’t it be great if wecould lower SHBG? With Winstrol we can. A fairly conservative oral dose of .2mg/kg of Winstrol has been shown to lower SHBG by close to 50%. (8)For me(200lbs) this would mean I would only need around 18mgs/day to free up half of my SHBG bound testosterone! For myomnipresent and hypothetical “100kg bodybuilder”- only 20mgs would be needed (he’s 220 lbs for the metrically impairedamong us). Now, with less SHBG floating around in me, my anabolic steroid cycle will be more effective, right? Right.But why can we only expect such a dramatic lowering of SHBG with the oral? Well, obviously, we’re taking advantage ofthe first pass through the liver, where we can have our Winstrol interact with SHBG where it’s produced- in theliver…without going through the bloodstream first. When we take a look at a study done comparing injectable vs. oral contraceptives, we find that the oral version at70mgs/week (10mgs/day given orally) is more effective at affecting SHBG levels than 400mgs/week given via aninjection! (9)In this study, testosterone undecanoate was given at a constant dose along with norestisterone (whichraises SHBG). What we see is that when norestisterone is given orally, it produces a far greater effect on SHBG, thanwhen it is administered via an injection. And this is even when the doses of the injectable are 4x higher!Here’s a chart, illustrating exactly what I’m talking about in this study, which I think suggests very strongly that injectableversions of drugs, when compared with the oral version, will have nowhere near as much of an effect on SHBG:Group I (Black Circles): Injections of 200 mg NETE at study wk 0, 6, 12, and 18 plus injections of 1000 mg TU at studywk 2, 6, 12, and 18 (T free window). Group II (White Diamonds): Injections of 1000 mg TU together with 400 mg NETEat study wk 0, 6, 12, and 18. Group III (Grey Squares): Injections of 1000 mg TU at study wk 0, 6, 12, and 18 combinedwith daily oral 10 mg norethisterone acetate (NETE) from week 0 to 24 (9)Of course, in this study, they’re looking at oral vs. injectable versions of a SHBG raising drug- but what we can take awayfrom it is that SHBG interaction with oral compounds is far more pronounced than it is with injectables. So lets take a small amount of Winstrol with our cycles, and free up some of those steroids we’re taking, right? Right!Unless of course, we’re talking about women here…I was recently asked why I recommend that women use the injectableversion of Winstrol over the oral. I was asked this question by someone, who I assumed had a female friend who wasconsidering using Winstrol. I then realized I was totally incorrect- not about Winstrol, but about the reason behind thequestion. You see…I saw a picture of the man who had first asked me the question, and it’s readily apparent to me that heprobably doesn’t actually know any women. But still, his question is valid and bears repeating and answering here. I recommend that women avoid the oral version of this product for the same reason that men will find that it gives theman increased synergy and effectiveness in their cycles. When SHBG is lowered in women, there is more free testosterone floating around. And as we’ve seen, the oral is going toaffect SHBG exponentially more than the injectable will. When we lower SHBG too much in women, we see a strongpositive correlation with hyperandrogenism (10 ), and hirsuitism (abnormal growth of body hair), as well In fact, non-SHBG-bound testosterone may actually be the defining characteristic for identifying hyperandrogenism in women. Inaddition, low SHBG contributes to menstrual irregularity.(11)Finally, and (partially) anecdotally, we also see a greater incidence of clitoral enlargement and acne when the oralversion of Winstrol is used by women instead of the injectable. The reasons for this are obvious- When we increase freetestosterone by lowering SHBG, we increase the amount of testosterone which is able to be 5a-reduced to DHT. DHT isthe primary culprit for steroid induced acne, and is also the hormone responsible for external genital enlargement.Clearly, this is why we see the increased level of clitoral hypertrophy as well as acne when oral Winstrol is used bywomen.We can also see increased acne when men use Winstrol orally, but these effects are relatively minor when a 2mg/kgdose is being used to increase the effectiveness of other steroids in a cycle. This isn’t carte blanche to go using Winstrolfor an extended period of time under the excuse that it’s increasing the overall effectiveness of the cycle. Stanozolol hassome of the worst liver toxicity (hepatoxicity) of any oral steroid on a mg for mg basis. In addition, it’s deleterious effectson your lipid profile (Cholesterol) are also very pronounced, even at low doses- 6mgs/day of Stanozolol can lower HDL(good cholesterol)by 33% and raise LDL (bad cholesterol) by 29% (12 ). So, hopefully, you’ve reached the end of this article and realized that Winstrol can be used in any cycle to increase theeffectiveness of it, but that it must be used sparingly due to it’s possible hepatoxicity and lipid profile effecting properties.Still, when used in heavy testosterone-based profiles, at a dose that will cut your SHBG levels in half, it can
Please Scroll Down to See Forums Below 
