Hey, I have that too, pain in the ass. I have high estrogen levels and when I take arimidex it completely goes away. I had to come off of arimidex for a month to prove to my endocrinologist that I really did have high estrogen levels, because it was in the normal range with .5mg a day. After a few weeks of being off, puffiness came right back. They're like a barometer for estrogen levels in my case.