High GI carbohydrates such as maltodextrin cause a very rapid and dramatic increase, or spike, in blood glucose levels. To clear this wave of glucos from the blood and equally massive influx of insulin is released. Now, insulin is not bad, but too much of it too fast is. This si exactly what happens when you ingest a lot of high GI carbs. Insulin is an anti-lipolytic hormone meaning that it prevens the breakdown of fat. It is also lipognesis promoting meanig that all those glucose molecules from your weight gainer shake that your body has no use for will be made into fat and stored in adipocytes. Insulin turns on the fat making machinery. When you eat low Gi carbs in frequent, but smaller, quanities you don't have this mass infusion of blood glucose and the body only needs a small amount of insulin to deal with the glucose. This small amount of insulin will be just sufficent to activate glucose transport systems in the myocytes, but not the adipocytes, provided calories aren't too high. Weight gain shakes have far more carbohydrate/calories than anyone needs in one sitting. By ingesting smaller more frequent meals blood glucose remains level and insulin very low. Insulin in high qunaities also is detrimental to arteries, the heart, and nerves. It can also lead to type 2 diabetes, or insulin insensitivity. In this case your muscle aren't activated properly by small amounts of insulin so they don't take up the glucose. The body thus produces more insulin, and then even more insulin, but the muscle still don't respond. This leave far too much glucose in the blood and it will be synthesized into fat. The problems only compound from there. The body is able to "handle" low GI carbs much more efficiently and thus onle small, safe amounts of insulin are released by the pancreas.
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