pls. post NEUROGENEX feedback HERE

[juve]

probably more effective to add a small amount of hydergine(very small) and selegiline (1mg ed or eod)

Macro, I'm curious about the above statement. I have found that Hydergine works very synergistically not only with Piracetam (several studies account for the effect), but with NRGNX overall. What is the amount that you recommend, ie. what do you mean by 'very small'? I take 2 tabs which constitutes 9mg of Hydergine. BTW I have never seen anything accounting for toxicity of hydergine before...what gives?

And as far Selegiline being better than Cabergoline, I disagree, at least for me Caber blows away l-Dep, but then everyone responds differently. Have never tried Bromo though..

 

[macrophage69alpha]

Macro, I'm curious about the above statement. I have found that Hydergine works very synergistically not only with Piracetam (several studies account for the effect), but with NRGNX overall. What is the amount that you recommend, ie. what do you mean by 'very small'? I take 2 tabs which constitutes 9mg of Hydergine. BTW I have never seen anything accounting for toxicity of hydergine before...what gives?

And as far Selegiline being better than Cabergoline, I disagree, at least for me Caber blows away l-Dep, but then everyone responds differently. Have never tried Bromo though..

from a health and "natural" mental state- selegiline is better. Caber is of course much stronger.

hydergine amplifies the effect too much in some people hence why the reccomended low dose- some people enjoy the higher dose that you use- it really varies- however best advice is to start low and work up- its rarely better the other way.

 

[dantitan]

Im a bit confused macro... to reach the full effects of hydergine people stay on it for at least a month... how can it be used sparingly.


Why should I skip hydergine if ive got tabs instead of liquid.


A warning... arcalion with piracetam and DMAE is a bit too much, bad combination IMO. Counterproductive for me at least.

 

[dantitan]

About Hydergine and the effects on dopamine... was on the other thread.

Despite the fact that hydergine has been used in the treatment of dementia for many years, its mechanism of action is still not clear. Current studies imply that the major effect of hydergine may be the modulation of synaptic neurotransmission rather than solely increasing blood flow as was once thought. A prominent feature that accompanies aging is an increase in monoamine oxidase (MAO) levels which results in decreased availability of catecholamines in the synaptic cleft. The aim of this study was to determine the effects of hydergine on the MAO activity in different brain regions (cortex, olfactory bulb, hypothalamus, hippocampus, striatum, cerebellum) of old (30 months) and adult (12 months) male Sprague-Dawley rats. In cortex and olfactory bulb MAO levels were higher in the aged group. In hippocampus and hypothalamus hydergine treatment caused significant decreases in MAO levels. An interaction between age and hydergine treatment was observed in the hypothalamus, hippocampus and cerebellum. The hydergine effect was more pronounced in the aged group in the hypothalamus and cerebellum, and more pronounced in the adult in the hippocampus. Our findings imply that increased brain MAO activity in aging can be modified by hydergine treatment in some brain regions.

 

[dantitan]

The effect of Co-dergocrine (Hydergine) on acetylcholine (ACh) release in the striatum and hippocampus has been studied by means of brain microdialysis and compared to the effect of SKF 38393 and of LY 171555 selective D1 and D2 dopamine (DA) receptor agonists, respectively. Co-dergocrine (1 and 5 mg kg-1 i.p.) as well as LY 171555 (0.2 and 0.5 mg kg-1 i.p.) decreased the extracellular concentration of ACh in the striatum, whereas SKF 38393 (5 and 10 mg kg-1 i.p.) increased it. On the other hand, Co-dergocrine (1 and 5 mg kg-1), LY 171555 (0.2 and 0.5 mg kg-1) and SKF 38393 (5 and 10 mg kg-1) increased ACh release in the hippocampus in a dose-dependent way. These results show that Co-dergocrine, which is widely used in the treatment of senile mental decline, enhances the release of ACh in the hippocampus in a similar manner to both D1 and D2 DA agonists. This effect might be relevant for the amelioration of cognitive processes. Moreover, our results which demonstrate that Co-dergocrine is able to decrease the release of ACh in the striatum, as are selective D2 agonists, suggest that Co-dergocrine may have a potential therapeutic benefit in Parkinsonian dementia.

 

[macrophage69alpha]

the issue was that in combination with neurogenex some people may find it to be too strong, hence the indication to start low and see how hydergine affects YOU (ie the individual).

JMHO

 

[dantitan]

Caution would be advised it seems.

One of the first things you read about when you read about SD's is the synergy between pira and hydergine. But from what I've read on boards people have difficulties getting it right, and some people will never get it right.

Paradoxical effects are an issue, but then again there are people who take large amount and dont feel totally stupid.


This was james south smart drug regime, dont know how he dose it though


My current nootropic intake includes:
Piracetam (2.4 grams, 2-4 times daily)
Pramiracetam (300mg twice daily)
Aniracetam (375 mg twice daily)
Oxiracetam (400 mg twice daily).
I also use:
Pyritinol (100-200 mg daily)
Hydergine (4.5-6.75 mg daily)
Vinpocetine (2.5-7.5 mg daily)
on occasion, especially when writing.

 

[EricDraven]

what are the effects of selegiline? and would it be beneficial to combine that with neurogenex? and where can you get it?

thanks.

 

[macrophage69alpha]

it inhibits MAO-b (which breaks down dopamine)
yes
IAS

 

[TraxZBT]

Might as well post my comments here. I've been on neurogenex for one week now. I've also bought 300 grams of piracetam from BAC and have been loading with that. To tell you the truth, I really can't notice any difference as of yet. I've been taking 6 pills for the first 3 days and 2 pills thereafter. As for the piracetam powder, i've been taking 5 grams a day (everything in the morning on an empty stomach.) I'll update if I notice a difference in cognitive abilities, but then again I really don't know what to look for in terms of positive effects.
Will update again in another week.