P Seven

[Fonz]

Well, since I cannot figure out what is causing the excessive oily skin, breakouts and now oily hair, I am d/c the P7. I have been using P7 (peppermint) for about 4 weeks, have decreased the dosage and still have the excessive oily skin. Have also noticed some H2O retention. Otherwise no other effects other than what I previously posted. I may start again in a week just to see what happens.

I use a lot of Fina.....and I get a pimple every now and then.

And no offense to anybody else, P7 makes you break out like crazy.

Make a 6-oxo-DHEA version WITHOUT the pregnenolone. Which is the culprit for sure. And then I'lll buy it again.

I had to stop the P7 b/c of the break-outs.

Never had them in my life.

Ohter than that, I have no problems with the P7.

Besides,

As i told Ulter before macro, its the DHEA analogue that produces the raised T3 levels.

Pregnelone's effects on mood is a dicey subject. Could be a placebo effect and we all should accept this as a possibility.

Fonz

 

[macrophage69alpha]

Pregnelone's effects on mood is a dicey subject. Could be a placebo effect and we all should accept this as a possibility.

Fonz

this is not accurate.. its, and its neurosteroid metabolites, role in mood is well established.

Fonz,

you are not the ideal subject.. the number of "ancillaries" you use is quite high..(interference, duplication, etc) plus you are fairly young (which is good for you ) but may diminish some of the benefits(as neurosteroid sysnthesis should be good.. though in very many young people this is not the case)... the mood effects are best seen among those with anxiety, depression, etc... if you feel relatively good all the time.. impact will be less as your neurochemistry does not need the "tweak".

but its neurological effects are undeniable.

 

[macrophage69alpha]

Pregnelone's effects on mood is a dicey subject. Could be a placebo effect and we all should accept this as a possibility.

Fonz

this is not accurate.. it, and its neurosteroid metabolites, role in mood is well established.

Fonz,

you are not the ideal subject.. the number of "ancillaries" you use is quite high..(interference, duplication, etc) plus you are fairly young (which is good for you ) but may diminish some of the benefits(as neurosteroid sysnthesis should be good.. though in very many young people this is not the case)... the mood effects are best seen among those with anxiety, depression, etc... if you feel relatively good all the time.. impact will be less as your neurochemistry does not need the "tweak".

but its neurological effects are undeniable.

 

[MS]

I agree I would like to try a "7-oxo DHEA only" version of this stuff, but either way I am grwoing to like P7 more and more as the days go by. I've already placed my second order. I don't know if it's the prenenolone or the 7-oxo, or the combo. And like FONZ, I prolly don't have any deficiency of pregnenolone to judge from my sides (which were the opposite of relaxing and calming). But I am now using it to ease my old joints and as a substitute for 'happy hour'. It's actually cheaper than booze, and possibly less detrimental to my aging liver (not sure about this one). Although pregnenolone (S) is clearly low in some depressed and anxious folks, and increasing pregnenolone through supps or antidepressants seems to increase neuroactive steroids in this population in parallel with symptom relief, it is still not clear if there are any 'mood' benefits to otherwise normal, healthy people. However, I am noticing some very subtle changes in mood and general sense of being which may be related to one of the steroids in P7. Hard to explain in words, but everything is sharper, clearer and more 'real' feeling?????

I would also like to try a 'blind crossover trial' of this stuff, where I get two bottles, one with the steroids and one with carrier only. This would help to sort out what is placebo and what is 'real'. I also think a similar trial with yohimburn would be beneficial, only carrier on one thigh and active ingredient on the other (but I don't know which is which). Of course, neither Fonz nor I seem to be 'normal' in the stressed out sense of the word, but I would also like to try this blind P7 trial on my SO too!

 

[macrophage69alpha]

MS and FONZ...

that can be arranged.. will see that the "materials" are made available for testing

 

[fawnmarie]

this is not accurate.. it, and its neurosteroid metabolites, role in mood is well established...
Fonz, you are not the ideal subject.. plus you are fairly young (which is good for you )
but its neurological effects are undeniable.

This is exactly what I posted to Fonz before, younger people rarely have a deficiency of pregnenolone and don't really notice much of difference by adding it. I took it at 33 and noticed nothing, took it at 38 and it was like being given a whole new lease on life. (And this was not P7 - but oral pregnenolone.)

It's effects are not a placebo - I've been using it off and on for over a year now, and it's wiped out depression that wasn't even handled by prescription AD's. Yes - I can tell when I haven't been taking it often enough. (I cycle it, as it tends to convert to androgens in me when my pregn. levels peak.)

Also, from what I understand, not only does adequate pregn. help stimulate T3, but vice versa - adequate T3 and cholesterol will ensure adequate pregnenolone, and very few young men on higher protein diets will have inadequate T3 or inadequate cholesterol.

A note to MS - your partner may be experiencing the same aggravation with P7 as with progesterone - in a lot of women it will stimulate a temporary case of estrogen dominance (including breast tenderness and over senstivity) - and this does go away in a couple of cycles.

The changes you are noticing in your mood and perspective is VERY common with pregnenolone. I myself don't find it "sedating", but rather makes me bouncy and happy. I don't get mad or angry, but I'm not groggy or sleepy, either. When I do sleep, I sleep very well. But for the most part it gives me a very steady "up".

Unfortunately, I haven't noticed any real increase in fat loss, but there you go. If anything, I've gained both fat and muscle. Maybe some of it is water retention.

As for the aromatase inhibitor - I wouldn't be interested in one, as I am 39 and already have been down to one ovary for 15 years, and depend highly on even my peripherally produced E to keep the mustache waxes down to a minimum.

Fawn

 

[Daisy_Girl]

Just a random thought, does P7 have any effect on the menstrual cycle? If so, what effect?

 

[MS]

fawnmarie, I agree 100% the effects of pregnenolone (and ordinary DHEA) are very real in some people. A group that I collaborate closely with are now testing transdermal DHEA and oral pregnenolone (separately) in a clinical setting to test their effects on major depression. So far the results are VERY promising, and if I were a pharmaceutical company making big bucks off of anti depressants, I would be kinda worried about now! Of course their are side effects, especially in women with the higher dose DHEA, but the side effects are generally much less than drugs like Prozac. AND it's cheap by comparison. It hasn't (yet) occurred to them to test the combo........ I dunno if 7-oxo DHEA has any of these anti-D effects, but it's peripheral effects and lack of conversion to E ot T make it a better choice for reducing sides associated with DHEA treatment, and I am curious to find out if it has any neurosteroid activity. Also agree that normal-high thyroid by itself may naturally increase pregnenolone and pregnenolone-S production. So a T3 cycle may have a similar effect? Conjugation of pregnenolone to pregnenolone-S in the brain is also linked to NPY levels, so I would expect a person's dieting status to have an effect on how they respond to transdermal (unconjugated) pregnenolone. It's a pretty complicated area of research, which is why the best idea is to just try it and see how you feel. Statistically, pregnenolone and it's conjugates are at their lowest when you hit 37-38 years of age, so what you experienced make 100% perfect sense to me. These levels seem to shoot up again briefly around perimenopause, and this may be why my SO is experiencing the sides more than younger folks??

Daisy_Girl, maybe Macrophage can answer that one.

 

[Friscochick]

Wait! Where can i order??

 

[Daisy_Girl]

Order: AF Store

https://anabolicfitness.net/shop/

And still curious about P7 and menstrual cycle...macro.....?