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Mr.X
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k6jatu37 said:
as long as you're using potassium and taurine you're fine.
•••Liquid Clen Vs Tabs•••
- Thread starter Buld0g
- Start date
as long as you're using potassium and taurine you're fine.
macrophage69alpha
New member
regardless of whether using tabs or liquid you really should take ALCAR for cardio protective benefits. In addition to taurine, potassium and magnesium.
J Appl Physiol. 2005 Apr;98(4):1379-86. Epub 2004 Dec 10. Related Articles, Links
beta2-Adrenergic receptor stimulation in vivo induces apoptosis in the rat heart and soleus muscle.
Burniston JG, Tan LB, Goldspink DF.
Research Institute for Sports and Exercise Sciences, Liverpool John Moores Univ., Webster St., Liverpool, L3 2ET, United Kingdom. [email protected]
High doses of the beta2-adrenergic receptor (AR) agonist clenbuterol can induce necrotic myocyte death in the heart and slow-twitch skeletal muscle of the rat. However, it is not known whether this agent can also induce myocyte apoptosis and whether this would occur at a lower dose than previously reported for myocyte necrosis. Male Wistar rats were given single subcutaneous injections of clenbuterol. Immunohistochemistry was used to detect myocyte-specific apoptosis (detected on cryosections via a caspase 3 antibody and confirmed with annexin V, single-strand DNA labeling, and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling). Myocyte apoptosis was first detected at 2 h and peaked 4 h after clenbuterol administration. The lowest dose of clenbuterol to induce cardiomyocyte apoptosis was 1 microg/kg , with peak apoptosis (0.35 +/- 0.05%; P < 0.05) occurring in response to 5 mg/kg. In the soleus, peak apoptosis (5.8 +/- 2%; P < 0.05) was induced by the lower dose of 10 microg/kg. Cardiomyocyte apoptosis was detected throughout the ventricles, atria, and papillary muscles. However, this damage was most abundant in the left ventricular subendocardium at a point 1.6 mm, that is, approximately one-quarter of the way, from the apex toward the base. beta-AR antagonism (involving propranolol, bisoprolol, or ICI 118551) or reserpine was used to show that clenbuterol-induced myocardial apoptosis was mediated through neuromodulation of the sympathetic system and the cardiomyocyte beta1-AR, whereas in the soleus direct stimulation of the myocyte beta2-AR was involved. These data show that, when administered in vivo, beta2-AR stimulation by clenbuterol is detrimental to cardiac and skeletal muscles even at low doses, by inducing apoptosis through beta1- and beta2-AR, respectively.
J Appl Physiol. 2005 Apr;98(4):1379-86. Epub 2004 Dec 10. Related Articles, Links
beta2-Adrenergic receptor stimulation in vivo induces apoptosis in the rat heart and soleus muscle.
Burniston JG, Tan LB, Goldspink DF.
Research Institute for Sports and Exercise Sciences, Liverpool John Moores Univ., Webster St., Liverpool, L3 2ET, United Kingdom. [email protected]
High doses of the beta2-adrenergic receptor (AR) agonist clenbuterol can induce necrotic myocyte death in the heart and slow-twitch skeletal muscle of the rat. However, it is not known whether this agent can also induce myocyte apoptosis and whether this would occur at a lower dose than previously reported for myocyte necrosis. Male Wistar rats were given single subcutaneous injections of clenbuterol. Immunohistochemistry was used to detect myocyte-specific apoptosis (detected on cryosections via a caspase 3 antibody and confirmed with annexin V, single-strand DNA labeling, and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling). Myocyte apoptosis was first detected at 2 h and peaked 4 h after clenbuterol administration. The lowest dose of clenbuterol to induce cardiomyocyte apoptosis was 1 microg/kg , with peak apoptosis (0.35 +/- 0.05%; P < 0.05) occurring in response to 5 mg/kg. In the soleus, peak apoptosis (5.8 +/- 2%; P < 0.05) was induced by the lower dose of 10 microg/kg. Cardiomyocyte apoptosis was detected throughout the ventricles, atria, and papillary muscles. However, this damage was most abundant in the left ventricular subendocardium at a point 1.6 mm, that is, approximately one-quarter of the way, from the apex toward the base. beta-AR antagonism (involving propranolol, bisoprolol, or ICI 118551) or reserpine was used to show that clenbuterol-induced myocardial apoptosis was mediated through neuromodulation of the sympathetic system and the cardiomyocyte beta1-AR, whereas in the soleus direct stimulation of the myocyte beta2-AR was involved. These data show that, when administered in vivo, beta2-AR stimulation by clenbuterol is detrimental to cardiac and skeletal muscles even at low doses, by inducing apoptosis through beta1- and beta2-AR, respectively.
TheAssholeFomerlyKnownAsDBBT
New member
Big Rick Rock
istrator
good info in this thread.
-BRR
-BRR
macrophage69alpha
New member
Big Rick Rock
istrator
macrophage69alpha said:
Please explain to our memebers how Turine and Alcar would be beneficial to their body in a Liquid Clenbuterol cycle.
-BRR
macrophage69alpha
New member
Taurine for cramping and energy depletion.
Alcar because its protective of cardiac (heart) tissue, which clen places strain on and may cause apoptosis (cell death) in at moderate to high doses (1mcg/kg- at least in animal models).
potassium for cramping and performance
magnesium for cramping, heart function, and strength
(as a side note- clen depletes taurine, potassium and magnesium)
Alcar because its protective of cardiac (heart) tissue, which clen places strain on and may cause apoptosis (cell death) in at moderate to high doses (1mcg/kg- at least in animal models).
potassium for cramping and performance
magnesium for cramping, heart function, and strength
(as a side note- clen depletes taurine, potassium and magnesium)
macrophage69alpha
New member
Big Rick Rock said:
did that cover it?
Big Rick Rock
istrator
macrophage69alpha said:
Some good advice there bro.
I have gotten cramps from Potassium/Sodium depletion before. It was NOT pretty! I had no control over my muscles. It felt like my hamstring was going to tear itself right off my leg.
-BRR
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