The active anabolic ingredient in Omnibolic is the known steroid, Ecdysterone. Imported directly from Russia, the Ecdysterone in this product is extracted from Rhaponticum carthamoides and is guaranteed to be 98% (or higher) pure. This (and only this) remarkable plant extract, (at this potency), has been proven in numerous clinical studies to be more anabolic than methandrostenolone (Dianabol), with no androgenic or other undesirable side effects. Omnibolic is a non-hormonal dietary supplement that will cause a huge increase in anabolism but will not effect hormone levels.
Omnibolic works by increasing nitrogen retention and increasing protein synthesis at the cellular level (for this reason we strongly recommend that you increase your daily dietary intake of protein while using this product). It has been scientifically proven, without a doubt, that increased nitrogen retention and resistance training will stimulate muscle growth and burn fat as much as 20 times more effective than without the increase in nitrogen retention caused by ecdysterone supplementation.
The Russian ingredients in Omnibolic have also been clinically proven to increase in strength and endurance. This is the same exact ingredient that the Russian government gave to its athletes prior to competitions in order to optimize performance while coming off anabolic steroids to beat doping tests. Strangely enough, many Russian athletes performed better in competition while using Ecdysterone than they did in preparation while on anabolic steroids.
If you are wondering why you have never heard of Ecdysterone before it is because this information has been somewhat classified until the collapse of the Soviet Union and since then it has been way too expensive (over $20,000 a kilo) to bring real Ecdysterone from Rhaponticum carthamoides to market. UNTIL NOW!
This is the first time ever that this material is being made available and you have our guarantee that nothing you have ever tried will work better than Omnibolic for adding lean muscle mass. Because Omnibolic is a non-hormonal supplement it can be safely used by both men and women. The Ecdysterone in this product is Ecdypure TM material, guaranteed to be 98% or higher pure Ecdysterone. Omnibolic will not cause a positive test result for any banned or controlled substance. Omnibolic is a 100% safe and legal dietary supplement.
Ecdysterone has also been shown to be an adaptogen. This basically means that it has other physiological advantages in addition to increasing muscular development. Part of the advantage of this product includes an increase in mental, physical and immunological capacity. The pioneer studies were conducted by Professor Vladimir Syrov of the Research Institute of Plant Substance of Chemistry, Academy of Science of Uzbekistan, and specifically proved that the ecdysterone derived from Rhaponticum carthamoides possessed anabolic properties in both animals and humans. His original work was done primarily with Rhaponticum carthamoides.
6-Keto Diosgenin (25R-Spirost-4-ene-3,6-diol)
Dr. Syrov and Dr. A.J. Kurmukov published a study entitled, "The Experimental Study of the Anabolic Activities of the 6-Keto Derivatives of Some Natural Sapogenins", in which they analyzed the various sterol compounds from these plant sources. They found several adaptogens in addition to the beta-ecdysterone, including agigenin, disogenin and alliogenin, all of which displayed further anabolic activity, but none of which displayed androgenic properties. This basically means that this group of sapogenins do not have any influence in elevating or decreasing the testosterone levels of the person taking them. This is precisely what the Russians wanted, since they were having several of the world class athletes fail urine tests in international competition because they were taking synthetic steroids. What Dr. Syrov and his colleagues further showed was a dramatic improvement in liver, kidney, heart and muscular activity, and a dramatic increase in the total amount of protein found within these organs. In other words, there is an increase in protein synthesis in all of the major organs of the body, including muscular tissue, with no effect on the hormonal activity of the body. This is remarkable and exciting because it thus poses no threat to the individual in terms of toxicity and/or the capacity to increase existing cancers. As a matter of fact, several South American physicians have used this compound extensively to battle cancer and even a very difficult disease known as Chronic Fatigue Syndrome, which is normally considered to be a viral infection.
How Does Ecdysterone Work?
In each cell there are 3 forms of ribonucleic acid (RNA) which are involved in the production of protein. All of this protein synthesis occurs at the level of the ribosome. Basically, the process involves 3 states:
1. Ribosomal RNA (rRNA) gives instructions to the poly-ribosomal complex to join together specific ribosomes into forming a complex (group). This is the manufacturing facility where the proteins and muscle tissue are formed.
2. Messenger RNA (mRNA) travels from the nucleus where it has received the specific genetic code on how to make a specific protein. This is very much like a reel-to-reel tape going through a computer in which specific instructions are being given at an extremely rapid rate. The mRNA travels into the poly-ribosomal complex and runs across the ribosomes, giving specific instructions which result in exact sequences of the 22 different amino acids being placed together to form a specific protein (muscle).
3. Transfer RNA (tRNA) then move the amino acids to the ribosomes so as to allow the mRNA tape to hook up the individual amino acids to form the polypeptides (protein chains).
Realize that the Russian and Japanese scientists determined the specific location of Ecdysterone's actions were at the level at which the transfer RNA translates amino acids into proteins at the ribosomes. Thus, Ecdysterone increases the rate at which proteins are manufactured. Synthetic steroids affect the instructions from the nucleus, called transcription. This can pose a problem in that, if one has hormonally sensitive cancer, it can increase the rate of cancer growth within the body. Ecdysterone, on the other hand, affects the translation of amino acids into protein, which does not influence the rate of growth of cancers. This makes the Ecdysterone products totally safe, having no effect on the hormonal levels of the body. Researchers have proven that beta-ecdysterone has no side effects, except that it improves liver function, kidney function, heart function, muscle size and physical performance. Because of the other sapogenins within the herbal complex there may even be other medicinal benefits which can help an individual, such as anti-viral, anti-bacterial and immune stimulating properties.
Citrulline Malate
Citrulline, although a non-essential amino acid, is not widely abundant in our daily diet. However, it plays a vital role in many important biological processes.
1. Increased NO Production
Of specific interest to all of us athletes in the trenches is it's role of regulating Nitric Oxide (NO). I mention this first only because the sport nutrition industry has been recently flooded with NO potentiating products comprised of L-Arginine and / or other Arginine salts, which until this day have been the most cost effective manner in improving NO function. It is well known in the scientific community that L-Arginine is a substrate for production of Nitric Oxide2, as well as catalyst for other metabolic reactions including its effects on insulin, various hormones and creatine synthesis.3
(The NO synthase (NOS) enzymes convert Arginine into Citrulline and NO)
So what is NO and what can it do for you? Nitric oxide is the cell-sign****g molecule that has a part in regulating blood flow, oxygen delivery, glucose uptake, muscle firepower, and muscle growth. Obviously the ability to control these physiological effects can be of tremendous value to athletes.
Unfortunately I think many of the companies currently marketing NO products are missing the boat by not including Citrulline Malate in the current crop of NO supplements. You see, many of Citrulline's functions stem primarily from its ability to increase plasma levels of Arginine endogenously (in the human body).4 And what is really so exciting about Citrulline is that it seems to increase plasma Arginine levels better than taking the amino acid Arginine itself.5 You read correctly!
Research has shown that supplementation of Citrulline raises Arginine levels more effectively than taking the same dose of straight Arginine. Keep in mind that Citrulline Malate's NO enhancing properties are just one of the unique benefits this nutrient offers to athletes. And if the enhanced pumps and improved nutrient delivery properties are the reason you are using Arginine based NO products, you need to pay attention to Citrulline Malate.
2. Reduces Lactic Acid and Ammonia
Here is something else you need to know about Citrulline... it is an intermediate in the Urea Cycle. The Urea Cycle is a system in the liver of carrier molecules and enzymes that convert nitrogenous wastes into urea and eliminates them from the body. The production and removal of urea is essential for the elimination of ammonia and toxic nitrogen metabolites. Ammonia is extremely toxic to all cells and excessive levels may even be fatal. Even in healthy athletes, the build up of ammonia can lead to extreme fatigue and more.6 It also reduces glycogen formation, and inhibits the energy cycle. Obviously this is what every athlete wants to avoid!
Unfortunately all exercise, anaerobic and aerobic exercise produces tons of this stuff.7 Ammonia also forms when bacteria in the intestinal tract breaks down protein. The point is that the more ammonia in your blood, the poorer your athletic performance.8 Citrulline Malate comes to the rescue once again by aiding in the elimination of amino acid byproducts of protein metabolism. Researchers also purpose that Citrulline Malate may help to eliminate the burn associated with lactic acid build up as well as reduce the negative effects of ammonia and bacterial endo toxins on performance. Demonstrations also show Citrulline Malate as having a protective effect against acidosis and ammonnia poisoning.12 The metabolic actions of Citrulline Malate clearly explain the anti-fatigue properties in man and shows great promise to its uses as a performance enhancer for athletes.
The Urea cycle splits Arginine into Ornithine and Urea. The urea is excreted as a waste product. Citrulline is synthesized from the Ornithine and carbamoyl phosphate. Citrulline is then converted back to Arginine.
3. Increases ATP and Phosphocreatine Recovery
No doubt there is a lot to get excited about when it comes to the performance enhancing potential of Citrulline Malate and how it works. Another study showed yet another way Citrulline Malate can benefit athletes - by increasing aerobic energy production.9 Studies show subjects using Citrulline Malate have an increase in the rate of muscle ATP (Andenosine Triphosphate, the major energy source within the cell) production during exercise and greater phosphocreatine recovery after exercise. So taking Citrulline Malate may result in muscles that can keep on going and going... completely smashing the aerobic threshold! These effects are more than likely mediated by the malate portion of the Citrulline Malate compound, which is a Krebs Cycle intermediate.
The Krebs Cycle refers to a portion of the metabolic pathway of amino acids in the conversion of sugars and fats into ATP, and the role of friendly bacteria (mitochondria) in our cells. The Krebs Cycle happens in the mitochondria, where sugar and fat pour in and are burned much like in a blast furnace, with a number of weak amino acids acting as a conveyor belt. Impaired ability to make ATP results in premature fatigue and "hitting the wall", unable to continue intense exercise.
Getting back to malate, it appears that it is synergistic when bonded to citrulline and this peptide may work better than supplementation of citrulline alone.10 While citrulline acts to increase NO and reduce performance inhibiting metabolic toxins, malate conditions the recycling of lactate and pyruvate, and takes part in the kreb cycle supplying instant and sustained energy.
Scientific Studies
Ecdysterone has been tested for its effects on work capacity, immune function, lean body mass and fat loss, among other variables in a number of scientific studies. The vast majority of research indicates an increase in test subjects' lean mass. Results were further improved when ecdysterone was consumed with protein.
Increase Protein Synthesis and Invoke Positive Nitrogen Balance:
Studies conducted in the Soviet Union in 1988 showed ecdysterone helps "increase hepatic protein synthesis and subsequently promote positive nitrogen balance!" How does this lead to more muscle mass? Simply: "the more nitrogen your body maintains and the greater rate of protein synthesis, the more mass, period." How, exactly, does ecdysterone do this?
V. Smetanin, researcher of the Smolenk State Medical Institute in Russia speculates that ecdysterone decreases urea concentration in the body and increases hemoglobin levels by increasing a process called erythropoiesis. Erythropoiesis is the development of mature red blood cells. This leads to a stimulation of the anabolic process in protein metabolism, which in turn leads to a positive nitrogen balance in the body.
Increase Lean Muscle Mass While Reducing Body Fat:
The most often quoted ecdysterone scientific study was published in Scientific Sports Bulletin by S. Simakin in 1988. The objective of Simakin's famous study was to determine the effect of ecdysterone on muscle tissue mass and fat mass, while testing for hormonal changes in the subjects.
For the study, three control factors were used: a placebo, protein, and ecdysterone with protein. The results were significantly in favor of the third factor. Of the 78 highly trained male and female athletes who consumed just protein, they showed only a slight increase in muscle mass for the 10 day period of time.
Those who used a placebo lost a slight amount of lean muscle, while those who used protein plus ecdysterone showed a 6-7% increase in lean muscle tissue with nearly a 10% reduction in fat! Let me say that again: A 10% reduction in fat and a 7% increase in lean muscle tissue in just 10 days! Safety testing was conducted during the same time period which showed no difference in hormonal balance. Wow, if ecdysterone plus protein can do this for highly trained athletes, just think what it can do for the average person!
Increase Stamina, Endurance, And Energy:
Ecdysterone was tested in another study performed in 1986 by B.Ya Smetanin. For this research, 117 highly trained speed skaters between the ages of 18 and 28 were tested for work capacity, body weight, lung capacity and VO2 max. The results speak for themselves: all of the said parameters increased as well as an increase in the O2 pulse max and an increase in the exhalation of CO2.
Basically, they received more oxygen to their cells! This equates to decreasing recovery time, maximizing performance, permitting optimal muscle anabolism and maximum fat reduction. It also means the athletes using ecdysterone compared to those on a placebo experienced increased stamina, endurance and energy.
That's not all! A study conducted using 112 athletes performed by B.G. Fadeev in Russia showed some very impressive overall results. However, by this time, the results should come as no surprise. 89% of those who supplemented with ecdysterone versus a placebo reported less fatigue, greater performance, more motivation, greater speed, and improved strength. How long did it take before these athletes reported these effects? Months? Weeks? No, five days. To make matters even better, no adverse side effects were reported.
Ecdysterone compared to methandrostenolone (D-Bol):
The action of methandrostenolone and ecdysterone on the physical endurance of animals and on protein metabolism in the skeletal muscles.
Author:
Chermnykh NS ; Shimanovski¨i NL ; Shutko GV ; Syrov VN
Farmakol Toksikol, 51(6):57-60 1988 Nov-Dec
Abstract:
The results of the comparative study on the myotropic activity of methandrostenolone and ecdysterone and their effects on physical endurance of animals suggested that ecdysterone possessing a wider spectrum of the anabolic action on the contractile proteins of the skeletal muscles exerts a more pronounced influence on physical endurance of animals without their preliminary training.
This study shows anabolic effects with no androgenic effects as compared to D-bol:
Anabolic activity of phytoecdysone-ecdysterone isolated from Rhaponticum carthamoides.
Author:
Syrov VN ; Kurmukov AG
Farmakol Toksikol, 39(6):690-3 1976 Nov-Dec
Abstract:
Introduction of phytiexdizone-exdisterone (0.5 mg/100 g) to rats for 7 days is shown to be attended by an accelerated body weight gain and also by a rising weight of the liver, heart, kidneys and musculus tibialis anterior. In these organs the total amount of protein increases. All of the above-stated changes are more marked when the substance is given to growing rats (70--80 g). In experiments on castrated sexually immature rats the androgenic action of exdisterone, unlike that of methandrostenolone, is not demonstrable.
Positive insulin response:
The effect of nerobol and ecdysterone on insulin-dependent processes linked normally and in insulin resistance
Author:
Kosovski¨i MI ; Syrov VN ; Mirakhmedov MM ; Katkova SP ; Khushbaktova ZA
Probl Endokrinol (Mosk), 35(5):77-81 1989 Sep-Oct
Abstract:
The effect of substances with anabolic activity (metandienone and ecdysterone phytoecdysteroid) on the manifestation of insulin effects was studied on a model of insulin resistance in rats induced by injections of hydrocortisone or by insulin insufficiency caused by alloxan. The sensitivity of the body to i. v. infusion of insulin and the reactivity of isolated fatty tissue to the hormone were increased after administration of these substances to test animals. The above effects of steroids were determined by nonspecific synthesis of total proteins in cells rather than by an increase in insulin secretion.
Also a very very strong adaptogen and antioxidant:
Antioxidant effect of 20-hydroxyecdysone in a model system
Kuz'menko AI - Ukr Biokhim Zh - 1999 May-Jun; 71(3): 35-8
Original Title:
Izuchenie antiokislitel'nogo effekta 20-gidroksiekdizona v model'noi sisteme.
Abstract:
Changes in the level of lipid free-radical oxidation in mitochondrial fraction at the presence of 20-hydroxyecdysone in 1, 2, 4, 6, 8 microM concentration with the help of a chemiluminescence (ChL) method were investigated in vitro. Statistically authentic reduction of ChL kinetic parameters--I(s) and tg alpha, at 20-hydroxyecdysone presence in concentration of 2 microM was found. 20-hydroxyecdysone administration in concentration 4 microM and more leads to the statistically authentic change of all four ChL parameters. The antioxidizing effect of 20-hydroxyecdysone was compared with action of such antioxidant as a hydroquinone. The higher activity of 20-hydroxyecdysone as an antioxidant in comparison with the hydroquinone was shown. For changes of all four measured kinetic parameters of ChL, concentration of the hydroquinone as much 2-fold than for 20-hydroxyecdysone is necessary. On the basis of our researches in the model system a conclusion was made that 20-hydroxyecdysone has an antioxidizing action on lipid free radical oxidation in mitochondrial fraction in dependents on concentration. 20-Hydroxyecdysone has antioxidizing properties directly, in these conditions in vitro, when its metabolites formation does not occur yet.
Insect hormones in vertebrates: anabolic effects of 20-hydroxyecdysone in Japanese quail.
Slama K - Experientia - 1996 Jul 15; 52(7): 702-6
Authors:
Slama K; Koudela K; Tenora J; Mathova A
Abstract:
Ecdysteroids are hormones controlling cell proliferation, growth and the developmental cycles of insects and other invertebrates. They are occasionally present in various unrelated plants for no apparent reason; no phytohormonal function has yet been identified. In certain cases, ecdysteroids are accumulated to high levels in leaves, roots or seeds. Some ecdysteroid-containing plants have been known as medicinal plants for centuries. One of them, Leuzea carthamoides Iljin (Asteraceae), growing in Central Asia, contains 0.4% ecdysteroid in dry roots and 2% in seeds. A pharmacological preparation from this plant, "Ecdisten', is already available as a commercial preparation for its anabolic, tonic and other effects, for medical use (review). It remained problematic, however, whether ecdysteroids were truly responsible for these effects, because Leuzea contains a number of other biologically active compounds in addition to ecdysteroids. We extracted and purified ecdysteroids from the seeds of Leuzea. With 6 g of 96% 20-hydroxyecdysone (20E), we made a large-scale feeding assay with Japanese quail to find out whether ecdysteroid alone could duplicate the anabolic effects of the seeds. We found that the 96% ecdysteroid increased the mass of the developing quails in a dose-dependent manner, with the rate of increase proportional to the ecdysteroid content in the seeds; there was a 115% increase in living mass with 100 mg kg-1 of pure 20E compared with 109.5% increase with 100-180 mg kg-1 20E equivalents in the seeds. We conclude that the plethora of growth-promoting, vitamin-like effects induced in vertebrates by Leuzea is mediated by ecdysteroids.
Study demonstrating the Anabolic effect of 6-Keto Diosgenin
[Experimental study of the anabolic activity of 6-ketoderivatives of certain natural sapogenins][Article in Russian]
Syrov VN, Kurmukov AG.
It is shown that 6-ketoderivatives of natural sapogenins, viz. agigenin, diosgenin and alliogenin, display the anabolic activity and do not manifest any androgenic properties. The compoud IV/(25 R)-5alpha-spirostan-2alpha, 3beta, 5alpha-triol-6-OH/produces an accelerated gain of weight in rats, and also an increase in the weight of the liver, heart, kidneys, musculus tibiliasis anterior and augments the total amount of protein therein. All of the above-mentioned changes become more pronounced with the study substance introduced to young animals. Castration of sexually immature rats greatly mitigates the anabolic effect of the compound IV.
PMID: 1028596 [PubMed - indexed for MEDLINE]
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