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Noopept...experiences from a long term user
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John Juan
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Neuroprotective and nootropic drug noopept rescues α-synuclein amyloid cytotoxicity.
AuthorsJia X, et al. Show all Journal
J Mol Biol. 2011 Dec 16;414(5):699-712. doi: 10.1016/j.jmb.2011.09.044. Epub 2011 Oct 1.
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Abstract
Parkinson's disease is a common neurodegenerative disorder characterized by α-synuclein (α-Syn)-containing Lewy body formation and selective loss of dopaminergic neurons in the substantia nigra. We have demonstrated the modulating effect of noopept, a novel proline-containing dipeptide drug with nootropic and neuroprotective properties, on α-Syn oligomerization and fibrillation by using thioflavin T fluorescence, far-UV CD, and atomic force microscopy techniques. Noopept does not bind to a sterically specific site in the α-Syn molecule as revealed by heteronuclear two-dimensional NMR analysis, but due to hydrophobic interactions with toxic amyloid oligomers, it prompts their rapid sequestration into larger fibrillar amyloid aggregates. Consequently, this process rescues the cytotoxic effect of amyloid oligomers on neuroblastoma SH-SY5Y cells as demonstrated by using cell viability assays and fluorescent staining of apoptotic and necrotic cells and by assessing the level of intracellular oxidative stress. The mitigating effect of noopept against amyloid oligomeric cytotoxicity may offer additional benefits to the already well-established therapeutic functions of this new pharmaceutical.
Copyright © 2011 Elsevier Ltd. All rights reserved.
AuthorsJia X, et al. Show all Journal
J Mol Biol. 2011 Dec 16;414(5):699-712. doi: 10.1016/j.jmb.2011.09.044. Epub 2011 Oct 1.
Affiliation
Abstract
Parkinson's disease is a common neurodegenerative disorder characterized by α-synuclein (α-Syn)-containing Lewy body formation and selective loss of dopaminergic neurons in the substantia nigra. We have demonstrated the modulating effect of noopept, a novel proline-containing dipeptide drug with nootropic and neuroprotective properties, on α-Syn oligomerization and fibrillation by using thioflavin T fluorescence, far-UV CD, and atomic force microscopy techniques. Noopept does not bind to a sterically specific site in the α-Syn molecule as revealed by heteronuclear two-dimensional NMR analysis, but due to hydrophobic interactions with toxic amyloid oligomers, it prompts their rapid sequestration into larger fibrillar amyloid aggregates. Consequently, this process rescues the cytotoxic effect of amyloid oligomers on neuroblastoma SH-SY5Y cells as demonstrated by using cell viability assays and fluorescent staining of apoptotic and necrotic cells and by assessing the level of intracellular oxidative stress. The mitigating effect of noopept against amyloid oligomeric cytotoxicity may offer additional benefits to the already well-established therapeutic functions of this new pharmaceutical.
Copyright © 2011 Elsevier Ltd. All rights reserved.
John Juan
New member
Benefits of NOOPEPT
Learning and memory:
*Enhanced drive and motivation.
*Improved memory, learning ability, and recall. Compared to piracetam, Noopept enhances not only the memory consolidation stage but also the memory retrieval steps.
*Helps catalyze the associative connections formation and improve communications between the right and left hemispheres of the brain.
Neuroprotection:
*Helps reduce damage to the brain brought by oxidative stress the same as human neurons apopsis
*An anti-oxidant that has an antagonizing effect on calcium excess.
Promotes brain health:
*Can be used to relieve effects of brain injuries, ischemia, and prenatal damage
*Improves age-related mental degeneration and decline
*Can help with amnesia.
Learning and memory:
*Enhanced drive and motivation.
*Improved memory, learning ability, and recall. Compared to piracetam, Noopept enhances not only the memory consolidation stage but also the memory retrieval steps.
*Helps catalyze the associative connections formation and improve communications between the right and left hemispheres of the brain.
Neuroprotection:
*Helps reduce damage to the brain brought by oxidative stress the same as human neurons apopsis
*An anti-oxidant that has an antagonizing effect on calcium excess.
Promotes brain health:
*Can be used to relieve effects of brain injuries, ischemia, and prenatal damage
*Improves age-related mental degeneration and decline
*Can help with amnesia.
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