Noopept...experiences from a long term user

[John Juan]

***Click on the SuperiorPeptide banner in my signature for (Noopept) in the Research Liquids section***

POSTED FROM LONGECITY.ORG

Noopept is my favourite nootropic, and I've tried a lot of them! But I've noticed especially after using noopept daily for several months (a little less than half a year), a lot more good effects than simply the cognitive enhancing effect I sought after when first starting.

First I want to shortly discuss the cognitive effects I've noticed. Noopept for me seems to work on several different levels. It enhances my perception quite remarkably. Vision is most noticeable. It's like I not only notice details more, but the overall picture becomes clearer. This is hard to explain, but it's a clear effect when visiting crowded centres where a lot of peripheral motion is present. My mind seem to be able to keep track of the relative motions of all the people in my periphery, as well as the details I'm focusing on at the moment. When starting dosing I found myself thoroughly examining the patterns in the side-walk and walls. Here the detail is more pronounced.

Other senses are affected as well. My olfactory sense seems to be able to distinguish certain scents to a larger degree, it's almost like the resolution has been turned up. Hearing was one of the things that clearly was affected when starting, but it is not as noticeable after long term dosing for me. At the start though, it was bizarre.

I tried some high dose experiments (40-50mg) the first few days and I seriously thought I had gotten some strange psychedelic RC instead! When listening to music there were a clear 'distortion' and my mind felt almost a little bit tripping. But no hallucinations were present, strange indeed. After a while I came to the conclusion that what really was happening was I had acquired a more selective ability to focus. The apparent distortions of music were in fact the result of my attention rapidly shifting to the environment to my thoughts and back to the music and causing a noticeable difference in the experienced music (does this make sense to someone else?).

After a few days (and lowering of the dose) the strange psychedelic effects did lessen sharply and I were more confident that it was actually noopept (mushroom smell). A friend after trying for a few days were really surprised that it worked (he's always been sceptical to my claimed effects of racetams and other nootropics)! He did say that the experience was like the "cognitive improvements from LSD without the hallucinations".

When it comes to memory I really notice a strong effect. It's not like I have a constant feeling of my present memory capabilities, but memories I thought were long lost suddenly appears in a vivid fashion. Also, it's much easier to keep track of how I got to a certain place in my mind, my spatial memory is clearly affected. I haven't measured direct learning though, but I have all reasons to expect it is improved.

After some week something totally unexpected happened. It suddenly were A LOT easier to deal with people! To understand the revolution here you must understand that I've always had great problems with understanding other peoples irrational rules (social customs) and behaviours, and therefore I've had a hard time accepting them. Also, I've a really hard time memorizing faces as well as understanding speech, they don't come as naturally to me as for other people. This leads to not an insecurity with people (not in the sense of ordinary social anxiety/phobia) but an unwillingness to be in crowded areas and confrontations because I simply don't understand behaviours or rules I'm supposed to align to (it's like a mystery). This has all changed DRAMATICALLY. With long term dosage, I more and more feel like "I get" humans so to say. I no longer have the constant sense that I'm caught in a herd of faceless animals when visiting crowded places and I can hear what people are saying over phone.

Another surprising effect is on my feelings. I wouldn't really call noopept directly euphoric, but definitely indirectly. I can suddenly find myself crying of joy on the bus because of the wonders of the existence of the mind and the universe. It's like I see the world more of the machine that it is, and the gears really are wonderful. Also people - they too are quite euphoric (someone said MDMA-like affections which is understandable).

Another effect is the pleasure derived from music. Before I of course enjoyed music, but now it's on a different plane. Music (especially orchestral) can at times feel like a really good massage for the eardrums (hard to explain the feeling, but it's pleasurable). Also I feel like I hear all the instrument at the same time to a greater degree.

I've read of some peoples experience with a lowering of the libido, and to some degree I agree but not entirely. For me I can maybe find myself overall less sexual, but when aroused there's no difference (no impotence so to say). Also there's a very clear shift in how much time I spend looking at pretty women when outside for example. It's like I more understand and appreciate the beauty and sexuality of the attractive gender.

When it comes to dosing daily over a long time, I find that taking a break on weekends (that is 2/7 days a week) seems sufficient. Tolerance builds up for sure, but I'm not really of the opinion that this is a result of a lesser sensitivity to the drug as to a more accustomed mind. I do mostly take these breaks because the effect on Monday is profound (with the crying and all) and to limit a possible tolerance (although I think it would be perfectly usable daily without breaks).

There's one clear side effect though, and that is the irritability. I as many others, have noticed an irritability especially directed at other people. This I do not have great problems with, and it's definitely worth to trade off for everything else. I'm suspected it has something to do with an increased perception (real or not) of intelligence, and therefore an irritation directed at those less fortunate (at the beginning I could have some serious rants at stupidity - not any more). Another reason I suspect is that as the focus are deepened, the irritation spawns from the distractions (which often are people). I'm glad to say however that with daily dosage it's a lot easier to handle.

Over long time I find an increasing effect though (as opposed to pure tolerance). Sure, I don't notice the direct effects as much but it really lingers and builds up which is noticeable when I compare my mindset now to that of the time before starting this experiment. I completely believe that noopept is causing some lasting changes in the brain. I'm suspecting this has to do with some build-up of neurotrophic factors (NGF/BDNF) but I don't have some scientific basis for that claim. It would though both explain the build-up and lasting effects I notice, as well as the initial euphoria (often reported from cerebrolysin users). I sure as hell wouldn't say that it looses it's effect after time, but yes, it's clearly less noticeable. That makes sense to me though, since we mostly thrive on difference and not a static state or slow build-up.

A summary of all of this would be a general feeling of a greater existence. It's like me and my mind are more 'there' in the environment and the world as a whole. I live, feel and experience more so to say. If being drunk is a low level of existence (I actually feel like it is), this is the exact opposite.

Oh, the doses I've been taking is mostly (95%) one time daily (at morning) of ~30mg.

So, thought about this? Is someone else having profound long term effects and thinking that they have finally found THE nootropic for them?

 

[Kevlor]

Noopept is the most favorite nootropic for many researchers. Started on this recently...

 

[Mr. Chicago]

Is this article supposed to make people want to try this stuff? Because it definitely did the opposite for me and I have absolutely no interest after reading it. Also, one paragraph says how it makes it so much easier to understand and deal with others, yet another explains a side effect is how it causes irritability towards people so I'm really lost to it's benefits, just sounds like a synthetic opiate if you ask me.

 

[John Juan]

My friend is into researching this compound. He said it makes his mind much sharper.

 

[John Juan]

Noopept Effects: Introduction to the Short-Term & Long-Term Effects


Noopept is one of the most exciting and powerful Nootropics to hit the market in a long time. As a derivative member of the Racetam family, the supplement has a very low level of toxicity is very well-tolerated by almost everyone. It poses very significant benefits for multiple dimensions of cognition including enhanced learning, reasoning and memory. Since it is much more potent than most of the other Racetam supplements, you will only need to take a very small dose in order for it to be effective, making it very affordable as well. Many users and potential users wonder exactly how Noopept works, whether there are any side effects, and what the potential short-term and long-term benefits might be. The following article will take you through some of the most common Noopept effects and mechanisms of action.

How Noopept Works:
Most people who are thinking about buying Noopept start their investigation by focusing the effects of this supplement without understanding exactly how it work. While the exact mechanism of action is still not entirely understood, it does appear to function similarly to Piracetam (the original Nootropic) in many ways. Once ingested orally, the supplement is absorbed through the GI tract and then eventually crosses the blood-brain barrier. It reaches maximum concentrations within the brain in about 15 minutes, so it is also pretty fast acting.


Even when compared to Piracetam, this supplement has a very high oral bioavailability rate. Some studies indicate this may be as high as 90 percent. This means that almost all of the Noopept taken will end up in circulation, reaching the brain and optimizing your cognitive processes.

Once in the brain, Noopept reacts strongly with the Glutamatergic AMPA receptor sites. It binds to these receptors site and then helps to prevent the break down of the neurotransmitter Glutamate. While other basic Nootropics such as Piracetam only have weak effects on Glutamate, this supplement appears to exert a much stronger influence. As it binds to these sites, Glutamate is allowed to move between brain cells more easily, helping to increase a number of cognitive benefits including enhanced brain plasticity. Glutamate is the most prevalent neurotransmitter in the brain and when you increase the efficiency with which it works you can dramatically improve the communications and computations that occur between neurons.

Possible Noopept Side Effects:
There are very few, if any, observed negative side effects related to Noopept. In fact, the evidence indicates that it might help to prevent headaches, which is a side effect commonly associated with many of the Nootropics. This is possibly due to the fact that Noopept influences Glutamate more directly.

Since a very small dose is typically required to show effects, Noopept does not ordinarily show any kind of gastrointestinal distress or other stomach issues. There is, however, a small chance of developing an allergic reaction. Additionally, a small number of users have reported some irritability when using this supplement for an extended period of time.

If high doses are used, there are some other potential side effects. In such cases, it is possible that much less of the supplement will be able to be absorbed into the bloodstream and this could lead to nausea and stomach upset. Other reported high dose side effects are insomnia and elevated blood pressure.

Short-Term Noopept Effects:
There are also some significant short-term benefits associated with Noopept. A number of studies have shown it to be effective at improving memory, learning capacity, and recall. The intensity of these effects will vary from person to person, with some people being able to recall dreams vividly and others simply feeling much more productive with increased energy and motivation. Noopept also may help to increase focus, concentration, and attention span. This can further enhance the effects of increased memory and learning capacity, especially for students who are studying for long periods of time. Noopept is also great for verbal fluency and linguistic processing, an important effect for anyone in social settings who wants to be able to think on their feet more quickly.



Long-Term Noopept Effects:
There are also a number of potentially long-term effects associated with Noopept. In the area of memory, this supplement is thought to have a strong positive effect on the later stages of the memory process including memory consolidation and retrieval. Both of these are thought to be more critical in the area of long-term memory development as opposed to short-term working memory.

This supplement is also very neuroprotective in nature. Not only does it act as an anti-oxidant, helping to rid the brain of calcium and other toxins, but it can serve to help defend against other poisons like apoptosis in the neurons. It may even be able to reverse damage done due to excessive alcohol consumption. Some people use Noopept supplements for anti-aging benefits and to potentially reduce the effects of cognitive decline with age.

Noopept has also been shown to increase levels of Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF). The NGF is believed to be responsible for influencing the growth and survival of certain types of neurons, while BDNF also encourages specialization of new neurons and synapses. It is these developments, particularly the new synapses which are thought to be very important in long-term memory, overall intelligence, and cognitive health. It may also help to form new connections and improve the overall level of communication between both hemispheres of the brain. The positive effects of Noopept most certainly outweigh the negatives and you will find this an excellent addition to any brain supplement regimen.

 

[John Juan]

I notice my memory is quite poor in the evening after a full day. Upon waking is the only time it's semi decent these days. Will look further into this supplement.

 

[Kevlor]

Noopept stacks very well with other nootropics... modafinil and alpha gpc...

 

[TrueLiberal]

I find piracetam to be both much cheaper and much more effective than noopept. Oxiracetam was effective for me also. I found oxiracetam to be more stimulating than piracetam, but not as good for focus or creativity. Pramiracetam was excellent for logical insight and mathematics. I didn't get much noticeable effect from aniracetam except for highly color saturated vision. I have also tried nefiracetam and thought it to be weaker than piracetam. At some point I may try phenylpiracetam.

The racetams do seem to work better when combined with a source of choline. I was taking CDP choline, but substituted it for the much cheaper choline citrate. I don't notice any difference when comparing the addition of CDP choline to choline citrate.

 

[TrueLiberal]

Noopept stacks very well with other nootropics... modafinil and alpha gpc...

I've have ok experiences with modafinil. It does a good job enhancing clarity. It does tend to make me irritable as a side effect though. Armodafinil works much better for me. It gives me even more clarity and a lot of energy.

 

[John Juan]

Modanifil makes me too up and down and emotional.

 

[John Juan]

Noopept: King of the Nootropics

Like most nootropic users, you likely supplement with nootropics because you want to become more efficient and more effective in your work or studies. And, if you're using nootropics to become better at what you're doing, it stands true that you also want to achieve the nootropic effect as proficiently as possible, right? If you're using racetams or thinking about trying a nootropic, then it's time to check out a very potent alternative, noopept. On the flip side, if you are using nootropics, there's also a good chance you could skyrocket the effectiveness of your current stack by adding noopept. Though it's not a brand new supplement, noopept is rightfully considered by many to be the king of nootropics.

What is Noopept?
Originally discovered in Russia, Noopept is a nootropic that also has neuroprotective properties and is available in the United States as a dietary supplement. It comes from the racetam family which is known for piracetam, aniracetam, pramiracetam, and oxiracetam. All of these are well known for their cognitive boosting properties. Noopept, however, packs a much larger punch and is 1000x stronger than piracetam, the most recognized of the racetam family. This gives it the advantage of providing more of the positive effects at a much lower dosage.

How Does Noopept Work?
Noopept has high oral bioavailability and easily crosses the blood-brain barrier. After consumption, noopept reaches the brain in about 15 minutes. It works like piracetam by having a strong reaction on glutamatergic AMPA receptors where it binds itself and allows the glutamate to move easily between brain cells.

Benefits of Noopept
So what exactly does Noopept do for you? When a supplement is this powerful, there are far reaching effects. The benefits cover the entire cognitive performance spectrum. They can generally be grouped into three categories: learning and memory, neuroprotection, and relieving of cognitive damage.

Learning and memory:

Enhanced drive and motivation.
Improved memory, learning ability, and recall. Compared to piracetam, Noopept enhances not only the memory consolidation stage but also the memory retrieval steps.
Helps catalyze the associative connections formation and improve communications between the right and left hemispheres of the brain.
Neuroprotection:

Helps reduce damage to the brain brought by oxidative stress the same as human neurons apopsis
An anti-oxidant that has an antagonizing effect on calcium excess.
Promotes brain health:

Can be used to relieve effects of brain injuries, ischemia, and prenatal damage
Improves age-related mental degeneration and decline
Can help with amnesia.

 

[John Juan]

Noopept and Learning: Noopept stimulates the release of certain neurotransmitters in the brain that are known to boost brain power when it comes to learning and memory. This is one of the reasons for which noopept is most sought-after. According to research and reviews, Noopept dramatically improves performance in all three areas of memory including formation, retrieval and restoration. When taking noopept, you will find it easier to recall new concepts learned as well as make associations with different concepts on several levels at once. If you often find yourself forgetting new information very shortly after hearing it for the first time, this supplement can boost levels of the Acetylcholine neurochemical which transmits signals between your different neurons. This results in better synapse plasticity which means your brain can form more connections and also improve reasoning and problem solving skills.

 

[John Juan]

GYM EXPERIENCE FROM NOOPEPT USER

In the gym, my focus has been otherworldly, and to be honest that’s where I’m most happy with it’s effects. It’s getting to the point that if I didn’t have anything else to do I would be in there for three hours. You just don’t want to stop. You have weights in front of you, so you lift them, again and again, tiredness be damned. More reps. More PRs. More sets. It doesn’t increase anything physically but mentally you’re god damned determined and nothing is getting in your way.

 

[John Juan]

Noopept is available in liquid oral form

 

[John Juan]

Noopept efficiency in experimental Alzheimer disease (cognitive deficiency caused by beta-amyloid25-35 injection into Meynert basal nuclei of rats).

AuthorsOstrovskaya RU, et al. Show all Journal
Bull Exp Biol Med. 2008 Jul;146(1):77-80.

Affiliation
Abstract
Experiments on adult Wistar rats showed that injection of beta-amyloid25-35 (2 microg) into Meynert basal nuclei caused long-term memory deficiency which was detected 24 days after this injection by the memory trace retrieval in conditioned passive avoidance reflex (CPAR). The effects of noopept, an original nootropic and neuroprotective dipeptide, on the severity of this cognitive deficiency were studied. Preventive (for 7 days before the injury) intraperitoneal injections of noopept in a dose of 0.5 mg/kg completely prevented mnestic disorders under conditions of this model. Noopept exhibited a significant normalizing effect, if the treatment was started 15 days after the injury, when neurodegenerative changes in the basal nuclei, cortex, and hippocampus were still acutely pronounced. The mechanisms of this effect of the drug are studied, including, in addition to the choline-positive effect, its multicomponent neuroprotective effect and stimulation of production of antibodies to beta-amyloid25-35. Noopept efficiency in many models of Alzheimer disease, its high bioavailability and low toxicity suggest this dipeptide for further studies as a potential agent for the treatment of this condition (initial and moderate phases).

 

[John Juan]

Noopept stimulates the expression of NGF and BDNF in rat hippocampus.

AuthorsOstrovskaya RU, et al. Show all Journal
Bull Exp Biol Med. 2008 Sep;146(3):334-7.

Affiliation
Abstract
We studied the effect of original dipeptide preparation Noopept (N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111) with nootropic and neuroprotective properties on the expression of mRNA for neurotropic factors NGF and BDNF in rat hippocampus. Expression of NGF and BDNF mRNA in the cerebral cortex and hippocampus was studied by Northern blot analysis. Taking into account the fact that pharmacological activity of Noopept is realized after both acute and chronic treatment, we studied the effect of single and long-term treatment (28 days) with this drug. Expression of the studied neurotropic factors in the cerebral cortex was below the control after single administration of Noopept, while chronic administration caused a slight increase in BDNF expression. In the hippocampus, expression of mRNA for both neurotrophins increased after acute administration of Noopept. Chronic treatment with Noopept was not followed by the development of tolerance, but even potentiated the neurotrophic effect. These changes probably play a role in neuronal restoration. We showed that the nootropic drug increases expression of neurotrophic factors in the hippocampus. Our results are consistent with the hypothesis that neurotrophin synthesis in the hippocampus determines cognitive function, particularly in consolidation and delayed memory retrieval. Published data show that neurotrophic factor deficiency in the hippocampus is observed not only in advanced Alzheimer's disease, but also at the stage of mild cognitive impairment (pre-disease state). In light of this our findings suggest that Noopept holds much promise to prevent the development of Alzheimer's disease in patients with mild cognitive impairment. Moreover, therapeutic effectiveness of Noopept should be evaluated at the initial stage of Alzheimer's disease.

 

[John Juan]

One of the most important things to remember is that Noopept does not appear to accumulate in the body or cause any type of drug dependency or addiction despite its potency.

 

[John Juan]

BENEFITS OF NOOPEPT

increased ability to learn

improved mood

decreased anxiety and feelings of depression

increased levels of energy and wakefulness

improved physical performance

improved memory and recall

improved patterns of speech

better logical thinking

enhanced perception and reflexes

improved sleep patterns

 

[John Juan]

[The original novel nootropic and neuroprotective agent noopept].

AuthorsOstrovskaia RU, et al. Show all Journal
Eksp Klin Farmakol. 2002 Sep-Oct;65(5):66-72. Article in Russian.

Affiliation
Abstract
The paper describes pharmacological properties of the new nootropic drug noopept created using an original approach based on the imitation of a nonpeptide nootrope structure by means of the short-peptide design. In particular, the structure of pyracetam was designed using dipeptide nootropes. Experimental investigations of noopept (N-phenylacetyl-L-polyglycine ethyl ester) showed that the new drug exceeds pyracetam both with respect to the effective dose level (1000 times lower for noopept than for pyracetam) and in the spectrum of mnemotropic activity. In contrast to pyracetam facilitating only the early stages of the memory process, noopept positively influences the memory consolidation and retrieval steps as well. The new drug produces an additional selective anxiolytic action. The pronounced neuroprotective effect of noopept was demonstrated both in vivo (in cases of various forms of brain ischemia) and in vitro (on various neuronal models). The drug action is based on the antioxidant effect, the antiinflammatory action, and the ability to inhibit the neurotoxicity of excess calcium and glutamate, and to improve the blood rheology. It was established for the first time that the activity of noopept is retained both upon parenteral introduction and upon peroral administration, which is a principal advantage of this proline-containing dipeptide over other, more complex peptides. This property provided a basis for the development of a medicinal form of noopept for peroral usage. At present, noopept tablets (noopept 5 and 10 mg) are under clinical assessment as a means of treating cognitive deficiency of cerebrovascular and post-traumatic origin.

 

[John Juan]

[On the mechanism of noopept action: decrease in activity of stress-induced kinases and increase in expression of neutrophines].

AuthorsOstrovskaia RU, et al. Show all Journal
Eksp Klin Farmakol. 2010 Dec;73(12):2-5. Article in Russian.

Affiliation
Abstract
The influence of noopept (N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111)--a drug combining the nootrope and neuroprotector properties--on the activity of mitogen-activated protein kinases (MAPKs) and the level of NGF and BDNF gene and protein expression in the frontal cortex, hippocampus, and hypothalamus has been studied in rats. Under conditions of chronic administration (28 days, 0.5 mg/day, i.p.), noopept decreased the activity of stress-induced kinases (SAPK/JNK 46/54 and pERK1/2) in rat hippocampus and increases the level of mRNA of the BDNF gene in both hypothalamus and hippocampus. The content of BDNF protein in the hypothalamus was also somewhat increased. In the context of notions about the activation of stress-induced kinases, as an important factor of amyloidogenesis and tau-protein deposition in brain tissue, and the role of deficiency of the neurotrophic factors in the development of neurodegenerative processes, the observed decrease in the activity of stress-activated MAPKs and increased expression of BDNF as a result of noopept administration suggest thatthis drug hasaspecific activity withrespect to some pathogenetic mechanisms involved in the Alzheimer disease.

PMID 21395007 [PubMed - indexed for MEDLINE]

 

[John Juan]

The one human study using Noopept (10mg taken twice a day) suggests that it is well tolerated for up to 56 days.

 

[John Juan]

Who has noopept experience here? Responses on other forums I'm on are very positive.

 

[John Juan]

. An in vitro study showed Noopept to be neuroprotective against the use of H2O2 in neuronal degradation, in both healthy brains as well as those with Down’s Syndrome in a dose-dependent manner

 

[John Juan]

Noopept can help to increase coordination and improve your general mood.

 

[Elvia1023]

From everything I have read so far I believe it's best to start at 10mg per day. If you want to move up after 1 week then add another 10mg in the day. I wouldn't think anymore than 40mg would ever be needed but everyone is different.

 

[John Juan]

From everything I have read so far I believe it's best to start at 10mg per day. If you want to move up after 1 week then add another 10mg in the day. I wouldn't think anymore than 40mg would ever be needed but everyone is different.

Makes sense. Always start low with any new compound to see how you react.

 

[John Juan]

Evidence indicates that noopept might help to prevent headaches,

 

[John Juan]

Noopept enhances your ability to learn.

 

[John Juan]

Nootropic drugs are considered to be non-toxic, not dangerous and non-addictive.

 

[John Juan]

[On the mechanism of noopept action: decrease in activity of stress-induced kinases and increase in expression of neutrophines].

AuthorsOstrovskaia RU, et al. Show all Journal
Eksp Klin Farmakol. 2010 Dec;73(12):2-5. Article in Russian.

Affiliation
Abstract
The influence of noopept (N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111)--a drug combining the nootrope and neuroprotector properties--on the activity of mitogen-activated protein kinases (MAPKs) and the level of NGF and BDNF gene and protein expression in the frontal cortex, hippocampus, and hypothalamus has been studied in rats. Under conditions of chronic administration (28 days, 0.5 mg/day, i.p.), noopept decreased the activity of stress-induced kinases (SAPK/JNK 46/54 and pERK1/2) in rat hippocampus and increases the level of mRNA of the BDNF gene in both hypothalamus and hippocampus. The content of BDNF protein in the hypothalamus was also somewhat increased. In the context of notions about the activation of stress-induced kinases, as an important factor of amyloidogenesis and tau-protein deposition in brain tissue, and the role of deficiency of the neurotrophic factors in the development of neurodegenerative processes, the observed decrease in the activity of stress-activated MAPKs and increased expression of BDNF as a result of noopept administration suggest thatthis drug hasaspecific activity withrespect to some pathogenetic mechanisms involved in the Alzheimer disease.

PMID 21395007 [PubMed - indexed for MEDLINE]

 

[John Juan]

[The original novel nootropic and neuroprotective agent noopept].

AuthorsOstrovskaia RU, et al. Show all Journal
Eksp Klin Farmakol. 2002 Sep-Oct;65(5):66-72. Article in Russian.

Affiliation
Abstract
The paper describes pharmacological properties of the new nootropic drug noopept created using an original approach based on the imitation of a nonpeptide nootrope structure by means of the short-peptide design. In particular, the structure of pyracetam was designed using dipeptide nootropes. Experimental investigations of noopept (N-phenylacetyl-L-polyglycine ethyl ester) showed that the new drug exceeds pyracetam both with respect to the effective dose level (1000 times lower for noopept than for pyracetam) and in the spectrum of mnemotropic activity. In contrast to pyracetam facilitating only the early stages of the memory process, noopept positively influences the memory consolidation and retrieval steps as well. The new drug produces an additional selective anxiolytic action. The pronounced neuroprotective effect of noopept was demonstrated both in vivo (in cases of various forms of brain ischemia) and in vitro (on various neuronal models). The drug action is based on the antioxidant effect, the antiinflammatory action, and the ability to inhibit the neurotoxicity of excess calcium and glutamate, and to improve the blood rheology. It was established for the first time that the activity of noopept is retained both upon parenteral introduction and upon peroral administration, which is a principal advantage of this proline-containing dipeptide over other, more complex peptides. This property provided a basis for the development of a medicinal form of noopept for peroral usage. At present, noopept tablets (noopept 5 and 10 mg) are under clinical assessment as a means of treating cognitive deficiency of cerebrovascular and post-traumatic origin.

 

[FitnessSeattle]

I have found, with extensive observation, that the so called short term memory issues that some folks have reported are actually ' trances or profound reveries, we get so fixated on internal content that we forget what we were were doing.

 

[John Juan]

I like the fact that noopept increases intellectual ability while reducing sleep disorders. Stimulant based drugs only fulfill half the equation there. Good luck sleeping well on modafinil.

 

[John Juan]

Noopept increases cognitive ability making test taking much easier in college.

 

[John Juan]

Noopept dose falls between 10 mg and 40 mg taken up to three times a day. You it to kick in. Because Noopept increases alertness and blood flow to the brain, it is recommended that you do not use this compound late in the evening if you want a full night of sleep. Some reviewers recommend cycling their Noopept dosage schedule to improve its effectiveness, but this has not been proven necessary so far. In fact, because the effects of this nootropic is cumulative in its effects, taking it in consistent dosages over a long period of time may give you better results.

 

[John Juan]

Noopept’s effectiveness may be due to the possibility that it is able to strengthen associative connections between left and right brain hemispheres

 

[John Juan]

Noopept also has been shown in rodent studies to have neuroprotective properties important for brain plasticity.

 

[John Juan]

The administration of noopept favorably influences the cognitive functions and suppresses the development of neurodegenerative processes.

 

[John Juan]

Increased short term memory would be a great thing in my life.

 

[John Juan]

Noopept efficiency in experimental Alzheimer disease (cognitive deficiency caused by beta-amyloid25-35 injection into Meynert basal nuclei of rats).

AuthorsOstrovskaya RU, et al. Show all Journal
Bull Exp Biol Med. 2008 Jul;146(1):77-80.

Abstract

Experiments on adult Wistar rats showed that injection of beta-amyloid25-35 (2 microg) into Meynert basal nuclei caused long-term memory deficiency which was detected 24 days after this injection by the memory trace retrieval in conditioned passive avoidance reflex (CPAR). The effects of noopept, an original nootropic and neuroprotective dipeptide, on the severity of this cognitive deficiency were studied. Preventive (for 7 days before the injury) intraperitoneal injections of noopept in a dose of 0.5 mg/kg completely prevented mnestic disorders under conditions of this model. Noopept exhibited a significant normalizing effect, if the treatment was started 15 days after the injury, when neurodegenerative changes in the basal nuclei, cortex, and hippocampus were still acutely pronounced. The mechanisms of this effect of the drug are studied, including, in addition to the choline-positive effect, its multicomponent neuroprotective effect and stimulation of production of antibodies to beta-amyloid25-35. Noopept efficiency in many models of Alzheimer disease, its high bioavailability and low toxicity suggest this dipeptide for further studies as a potential agent for the treatment of this condition (initial and moderate phases).

 

[John Juan]

Noopept stimulates the expression of nerve growth factor which is a small secreted protein that is important for the growth, maintenance, and survival of certain target neurons (nerve cells).

 

[John Juan]

Neuroprotective and nootropic drug noopept rescues α-synuclein amyloid cytotoxicity.

AuthorsJia X, et al. Show all Journal
J Mol Biol. 2011 Dec 16;414(5):699-712. doi: 10.1016/j.jmb.2011.09.044. Epub 2011 Oct 1.

Affiliation
Abstract
Parkinson's disease is a common neurodegenerative disorder characterized by α-synuclein (α-Syn)-containing Lewy body formation and selective loss of dopaminergic neurons in the substantia nigra. We have demonstrated the modulating effect of noopept, a novel proline-containing dipeptide drug with nootropic and neuroprotective properties, on α-Syn oligomerization and fibrillation by using thioflavin T fluorescence, far-UV CD, and atomic force microscopy techniques. Noopept does not bind to a sterically specific site in the α-Syn molecule as revealed by heteronuclear two-dimensional NMR analysis, but due to hydrophobic interactions with toxic amyloid oligomers, it prompts their rapid sequestration into larger fibrillar amyloid aggregates. Consequently, this process rescues the cytotoxic effect of amyloid oligomers on neuroblastoma SH-SY5Y cells as demonstrated by using cell viability assays and fluorescent staining of apoptotic and necrotic cells and by assessing the level of intracellular oxidative stress. The mitigating effect of noopept against amyloid oligomeric cytotoxicity may offer additional benefits to the already well-established therapeutic functions of this new pharmaceutical.

Copyright © 2011 Elsevier Ltd. All rights reserved.

 

[John Juan]

Noopept is also an "immunocorrector" in mice.

 

[John Juan]

Noopept is said to be one of the strongest Piracetam analogues available, and works similarly in terms .

 

[John Juan]

Who has used noopept? What were your experiences?

 

[John Juan]

Noopept is said to exhibit a sense of euphoria initially.

 

[John Juan]

Benefits of NOOPEPT

Learning and memory:

*Enhanced drive and motivation.
*Improved memory, learning ability, and recall. Compared to piracetam, Noopept enhances not only the memory consolidation stage but also the memory retrieval steps.
*Helps catalyze the associative connections formation and improve communications between the right and left hemispheres of the brain.

Neuroprotection:

*Helps reduce damage to the brain brought by oxidative stress the same as human neurons apopsis
*An anti-oxidant that has an antagonizing effect on calcium excess.

Promotes brain health:

*Can be used to relieve effects of brain injuries, ischemia, and prenatal damage
*Improves age-related mental degeneration and decline
*Can help with amnesia.

 

[John Juan]

Noopept users claim it allows you to get more accomplished by increasing your ability to focus on the task at hand.

 

[John Juan]

Noopept helps to restore memory and cognitive functions, disturbed as a result of brain injury, ischemia, hypoxia, the effects of alcohol and other toxic substances.

 

[John Juan]

We have a new nootropic in the works that includes noopept and a host of amazing neurological boosters. Be on the look out...

 

[John Juan]

Noopept offers must faster memory retrieval

 

[John Juan]

Noopept efficiency in experimental Alzheimer disease (cognitive deficiency caused by beta-amyloid25-35 injection into Meynert basal nuclei of rats).

AuthorsOstrovskaya RU, et al. Show all Journal
Bull Exp Biol Med. 2008 Jul;146(1):77-80.

Affiliation
Abstract
Experiments on adult Wistar rats showed that injection of beta-amyloid25-35 (2 microg) into Meynert basal nuclei caused long-term memory deficiency which was detected 24 days after this injection by the memory trace retrieval in conditioned passive avoidance reflex (CPAR). The effects of noopept, an original nootropic and neuroprotective dipeptide, on the severity of this cognitive deficiency were studied. Preventive (for 7 days before the injury) intraperitoneal injections of noopept in a dose of 0.5 mg/kg completely prevented mnestic disorders under conditions of this model. Noopept exhibited a significant normalizing effect, if the treatment was started 15 days after the injury, when neurodegenerative changes in the basal nuclei, cortex, and hippocampus were still acutely pronounced. The mechanisms of this effect of the drug are studied, including, in addition to the choline-positive effect, its multicomponent neuroprotective effect and stimulation of production of antibodies to beta-amyloid25-35. Noopept efficiency in many models of Alzheimer disease, its high bioavailability and low toxicity suggest this dipeptide for further studies as a potential agent for the treatment of this condition (initial and moderate phases).

PMID 19145356 [PubMed - indexed for MEDLINE]

 

[John Juan]

SuperiorPeptide is coming out with a combination nootropic and somatostatin inhibitor that will contains noopept, huperzine A, and several other nootropics.

 

[John Juan]

Post from a noopept user...

"I’m convinced that Noopept is the best traditional nootropic drug available in terms of price and efficacy."

 

[John Juan]

Post from a Superior noopept user at another forum...

"A little update... I am doing noopet 2xd and so is my wife. I do believe its working for both. Enough for me to order 8 bottle before the bogo went off we will blow thru 2 bottles a month. It is g2g give you a good sense of well being and mind is sharper. I actually feel a little more comfortable talking to new people now."

 

[John Juan]

Comparative activity of proline-containing dipeptide noopept and inhibitor of dipeptidyl peptidase-4 sitagliptin in a rat model of developing diabetes.

AuthorsOstrovskaya RU, et al. Show all Journal
Bull Exp Biol Med. 2014 Jan;156(3):342-6. doi: 10.1007/s10517-014-2345-z. Epub 2014 Jan 15.

Affiliation
Abstract
Developing diabetes was modeled on adult male Wistar rats by repeated intraperitoneal injections of streptozotocin in a subdiabetogenic dose of 30 mg/kg for 3 days. Proline-containing dipeptide drug Noopept or a standard diabetic drug dipeptidyl peptidase-4 inhibitor sitagliptin was administered per os in a dose of 5 mg/kg before each injection of the toxin and then for 16 days after streptozotocin course. In active control group, spontaneously increase glucose level and reduced tolerance to glucose load (1000 mg/kg intraperitoneally) were observed on the next day after the third administration of toxin. Basal glucose level decreased by day 16, but glucose tolerance remained impaired. Noopept normalized the basal blood glucose level and tolerance to glucose load on the next day after administration of streptozotocin. The effect of Noopept persisted to the end of the experiment. At early terms of the experiment, sitagliptin was somewhat superior to Noopept by the effect on baseline glucose level, but was inferior by the influence on glucose tolerance.. By the end of the experiment, Noopept significantly (by 2 times) surpassed sitagliptin by its effect on glucose tolerance.

 

[John Juan]

[On the mechanism of noopept action: decrease in activity of stress-induced kinases and increase in expression of neutrophines].

AuthorsOstrovskaia RU, et al. Show all Journal
Eksp Klin Farmakol. 2010 Dec;73(12):2-5. Article in Russian.

Affiliation
Abstract
The influence of noopept (N-phenylacetyl-L-prolylglycine ethyl ester, GVS-111)--a drug combining the nootrope and neuroprotector properties--on the activity of mitogen-activated protein kinases (MAPKs) and the level of NGF and BDNF gene and protein expression in the frontal cortex, hippocampus, and hypothalamus has been studied in rats. Under conditions of chronic administration (28 days, 0.5 mg/day, i.p.), noopept decreased the activity of stress-induced kinases (SAPK/JNK 46/54 and pERK1/2) in rat hippocampus and increases the level of mRNA of the BDNF gene in both hypothalamus and hippocampus. The content of BDNF protein in the hypothalamus was also somewhat increased. In the context of notions about the activation of stress-induced kinases, as an important factor of amyloidogenesis and tau-protein deposition in brain tissue, and the role of deficiency of the neurotrophic factors in the development of neurodegenerative processes, the observed decrease in the activity of stress-activated MAPKs and increased expression of BDNF as a result of noopept administration suggest thatthis drug hasaspecific activity withrespect to some pathogenetic mechanisms involved in the Alzheimer disease.

PMID 21395007 [PubMed - indexed for MEDLINE]

 

[John Juan]

The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer's disease model.

AuthorsOstrovskaya RU, et al. Show all Journal
J Psychopharmacol. 2007 Aug;21(6):611-9. Epub 2006 Nov 8.

Affiliation
Abstract
The effects of the novel proline-containing nootropic and neuroprotective dipeptide, noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) were investigated in NMRI mice following olfactory bulbectomy. We have shown previously that these animals developed Alzheimer's disease (AD)-like behaviour, morphology and biochemistry including impairment of spatial memory, regional neuronal degeneration and elevated Abeta peptide brain levels. In the current investigation, spatial memory was assessed using the Morris water maze and serum antibodies to in vitro morphologically characterized amyloid structures of both Abeta((25-35)) peptide and equine lysozyme, as well as to neurotrophic glial factor S100b, were analyzed by enzyme-linked immunosorbent assay (ELISA). Noopept (administered at a dose of 0.01 mg/kg for a period of 21 days and during a further 5 days training) restored spatial memory and increased serum antibody levels to oligomers of Abeta((25-35)) peptide but not to equine lysozyme amyloid or S100b protein in bulbectomized animals. The positive immunotropic effect of noopept to Abeta((25-35)) peptide prefibrillar aggregates was more marked in sham-operated compared to the bulbectomized subjects which were characterized by an overall suppression of immunoreactivity. Enhancement of the immune response to Abeta((25-35)) peptide prefibrils caused by noopept may attenuate the neurotoxic consequences of amyloid fibrillization and also be associated with an improvement in spatial memory in bulbectomized mice. These actions of noopept, combined with its previously reported neuroprotective and cholinomimetic properties, suggests that this dipeptide may well be useful for improving cognitive deficits induced by neurodegenerative diseases.

 

[John Juan]

Post from a SuperiorPeptide customer...

"I'm 53 years old, I was starting to get nervous about my memory, losing Shit, trying to recall actors from a movie and drawing a blank. So I did some research and found Noopept. JJb a Rep for Superior and long term user, posted his thoughts and a few articles, Research Papers etc. Anyway started it 4 days ago, Skeptical as usual ,and this Shit actually works! I don't have total Recall but my memory ,mood and energy level are definitely better."

 

[Elvia1023]

I could do with a good mental boost now. This and huperzine a would be fantastic... especially when on peptides.

 

[John Juan]

I could do with a good mental boost now. This and huperzine a would be fantastic... especially when on peptides.

Absolutely! I'm ordering some when I get back to work after my vacation. Those 5am wake ups are not friendly. I need the extra brain power. Noopept is a Russian compound. Russians seem advanced in the use of many compounds.

 

[John Juan]

My buddy just started noopept. He has noticed better quality of sleep. I did a google search and found noopept improves sleep and increases dreaming.

 

[SunTzu]

I haven't tried the noopept mentioned here but I have used it before and found it to be very helpful. I honestly prefer using Piracetam and Sunifiram together to give myself a cognitive push.

 

[fastrip]

Noopept has it's place however, it can slow the brain down. I only use it if i will be answering questions or needing something to be done perfect. It all depends on the individual. Like the first time i took it, it was great, sure, but as i kept on taking it i felt like i was becoming mentally slower. When i picture something i'm about to do and plan on doing it fast, i do it exactly how i planned it out, but if i was to take noopept now, i would be doing a bunch of things unnecessary in the process which to someone else would seem more professional and dedicated. It's like when you want to wrap a present, you wrap it normally, no one is going to see how accurately you folded the wrapping paper or how precise you stuck the tape on so either side is matched perfectly right? Well on noopept, you will do exactly that, waste valuable time when it's completely unnecessary.

Edit: Iv'e also got another word of advice. Do not take any racetams with your whey protein shake, unless u want to feel braindead. They should be taken first thing in the morning on off days and right before workout on on days. Dosing twice per day for some people is too much for the brain, it doesn't have to do with how mentally strong you are or how much muscle you have. Everyone's body works different and these kind of supplements have the potential to space you out, and they are very good at that if you take too much in 1 day.

 

[SunTzu]

Yea the only nootropics I take prior to working out or exercising would be Phenylpiracetam and Oxiracetam. I've never noticed a braindead or groggy feeling after taking nootropics, aside from when I first started taking Aniracetam which made me drowsy the first few weeks of taking it.

 

[John Juan]

Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation.

AuthorsOstrovskaya RU, et al. Show all Journal
J Biomed Sci. 2014 Aug 6;21(1):74. [Epub ahead of print]

Affiliation
Abstract
BackgroundNoopept (N-phenyl-acetyl-L-prolylglycine ethyl ester) was constructed as a dipeptide analog of the standard cognition enhancer, piracetam. Our previous experiments have demonstrated the cognition restoring effect of noopept in several animal models of Alzheimer disease (AD). Noopept was also shown to prevent ionic disbalance, excitotoxicity, free radicals and pro-inflammatory cytokines accumulation, and neurotrophine deficit typical for different kinds of brain damages, including AD. In this study, we investigated the neuroprotective action of noopept on cellular model of AD, Aß25¿35-induced toxicity in PC12 cells and revealed the underlying mechanisms.ResultsThe neuroprotective effect of noopept (added to the medium at 10 ¿M concentration, 72 hours before ¿ß25¿35) was studied on ¿ß25¿35-induced injury (5 ¿M for 24 h) in PC12 cells. The ability of drug to protect the impairments of cell viability, calcium homeostasis, ROS level, mitochondrial function, tau phosphorylation and neurite outgrowth caused by ¿ß25¿35 were evaluated.Following the exposure of PC12 cells to ¿ß25¿35 an increase of the level of ROS, intracellular calcium, and tau phosphorylation at Ser396 were observed; these changes were accompanied by a decrease in cell viability and an increase of apoptosis. Noopept treatment before the amyloid-beta exposure improved PC12 cells viability, reduced the number of early and late apoptotic cells, the levels of intracellular reactive oxygen species and calcium and enhanced the mitochondrial membrane potential. In addition, pretreatment of PC12 cell with noopept significantly attenuated tau hyperphosphorylation at Ser396 and ameliorated the alterations of neurite outgrowth evoked by ¿ß25¿35.ConclusionsTaken together, these data provide evidence that novel cognitive enhancer noopept protects PC12 cell against deleterious actions of Aß through inhibiting the oxidative damage and calcium overload as well as suppressing the mitochondrial apoptotic pathway. Moreover, neuroprotective properties of noopept likely include its ability to decrease tau phosphorylation and to restore the altered morphology of PC12 cells. Therefore, this nootropic dipeptide is able to positively affect not only common pathogenic pathways but also disease-specific mechanisms underlying Aß-related pathology.