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Nolva vs. Arimedex!

Jenetic said:
It's virtually impossible to hit undectable levels of estrogen.

The majority of estrogen in males is derived from the extraglandular aromatization of testosterone and androstenedione to estradiol and estrone, respectively. The testes secrete 6-10 mg of estradiol and 2.5 mg of estrone per day (15% of estradiol and 5% of estrone). This means that there are still approximately 20% Estrogens detectable, even if armoatase activity was completely stopped.

The optimal dosage will vary depending on the individual and their goal. Another alternative, for those whom are concerned, is to use 0.5 mgs arimidex ED/EOD in combination with 10 mgs nolvadex ED. This combination prevents a drastic overall reduction in estrogen (less of an impact on cholesterol) and receptor specific protection. Also, nolvadex will have an added bennefit in this equation for it's ability to increase HDL. Regardless, the elevated HDl concetrations are not permamnent and subside shortly post cycle. Cholesterol is another issue that should be controlled during cycle as well as recovered post cycle.

Jenetic

Help me understand. As i know now, the majority of estrogen is extraglandulary produced via the aromtose enzyme. I am under the impression that fat cells complete a large portion of this process, and if so then i feel that blocking estrogen with smaller doses of arimidex and nolva (which is what i do btw)is more imprtant in a person with more fat on their frame especially if fat loss is important. Would you agree?
 
GREGORY said:
Help me understand. As i know now, the majority of estrogen is extraglandulary produced via the aromtose enzyme. I am under the impression that fat cells complete a large portion of this process, and if so then i feel that blocking estrogen with smaller doses of arimidex and nolva (which is what i do btw)is more imprtant in a person with more fat on their frame especially if fat loss is important. Would you agree?

Good observation. Yes, I do concur on this issue. The extent to which it occurs is highly dependant on the individuals sensitivity and genetic predisposition. Regardless, the estrogenic related accumulation fat can and will occur if the indiviual has not managed estrogen with an aromatase inhibitor during the cycle. The use of an aromatase inhibitor in regards to lipolysis and the management of adipogenesis is clearly beneficial, but the bottom line is that there are no excuses for having a poor diet and lack of dedication when bulking or cutting.

Jenetic
 
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What happens if I cut my Arimidex back to say .5mg every other day? On a cycle of deca/dbol/winny will the arimidex not be effective. I have researched the topic, yet nothing seems to be solid.
 
The reason you have not found a definitive answer is because there isn't one. Estrogen management is varies depending on the individuals genetic predisposition and goals. Your only solution is to perform blood work during your cycle. This should provide a concise answer as to how you should proceed with adjusting your dosage, if necessary.

Jenetic
 
Jenetic said:
The reason you have not found a definitive answer is because there isn't one. Estrogen management is varies depending on the individuals genetic predisposition and goals. Your only solution is to perform blood work during your cycle. This should provide a concise answer as to how you should proceed with adjusting your dosage, if necessary.

Jenetic


2nd
 
Anthony Starks said:
Why is everyone going with nolva and adex over femera?

The primary reason that Arimidex is preferred over Femara is due to the price and availability of pharmaceutical grade products. The actions of Nolvadex are completely different than that of aromatase inhibitors such as Arimidex or Femara.

Jenetic
 
Jenetic: So now that femera is relatively easy to get, should I replace Nolvadex in my PCT with Femera? I understand the action is different, but it would accomplish the same thing, only without decreasing IGF, correct? Karma, and thanks!
 
An aromatase inhibitor is best used during your cycle for estrogen management. Therefore, it is not necessary to use it during PCT unless your estrogen levels are elevated due to improper management during your cycle. During PCT, it is also important for your estrogen levels to return to homeostasis. Nolvadex has no effect on serum estrogen. Nolvadex is used as an anti estrogen and to continue pituitary LH secretion once HCG has been discontinued.

Jenetic
 
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