nizoral shampoo everyday?

[chazk]

nizoral did nothing for me..i used it for over three years

your not alone i did a google and researched it very well. seems alot of people said the same as you it did nothing. But on the other hand you claimed it nothing but you used it for 3 years,so just maybe you would have lost hair faster or lot more of it with out nizoral.I'm using it anyways becuase its cheap combination with t-gel just becuase it better then nothing i suppose

 

[c3bodybuilding]

I use it about twice a week. My hair is thick as a rug (thank the lord!) but you can never be too careful! As Macro put, anymore than 2-3x weekly feels too harsh on my hair. Remember you CAN have too much of a good thing. Make sure to lather it up good and leave it in for about a minute or two. I follow it up with their conditioner which has a nice minty tingle to it, lol. Good luck.

 

[lanky]

your not alone i did a google and researched it very well. seems alot of people said the same as you it did nothing. But on the other hand you claimed it nothing but you used it for 3 years,so just maybe you would have lost hair faster or lot more of it with out nizoral.I'm using it anyways becuase its cheap combination with t-gel just becuase it better then nothing i suppose

the debate on wheather nizoral has any effect on hairloss has become warped over the years...it is a dandruff and seborrheic keratosis shampoo. it has shown effetiveness in increasing hair diameter and thickness so to speak in the individuals with thinning due to those two conditions..not everyone with dandruff and sebum problems have thinning hair..the ones with severe problems can have hairloss....ketoconazole(the active ingrediant in nizoral shampoo) is also used as an antifungal that has been shown to have some anti androgen activity when taken ORALLY as a pill..it is very hepatoxic and its antiandrogenic effects are systemic involving not just 5 alpha reductase, in general it is not .

the following is not my writing:
The major drawbacks of ketoconazole therapy are from the occasionally seen adverse reactions. It may induce anorexia, nausea and vomiting [462, 591]. Increase in transaminase levels and hepatoxicity may occur [1318, 2338]. Ketoconazole may decrease testosterone and cortisol levels, resulting in gynecomastia and oligospermia in men and menstrual irregularities in women [1643, 2213].

The effects of ketoconazole on functions of the thyroid gland have also been investigated. There have been a number of reports suggesting that ketoconazole may have antithyroid function via impairment of thyroglobin iodination and iodothyrosine coupling. In vitro, ketoconazole has been found to form a complex with iodine and inhibit lactoperoxidase. In vivo experiments in rats have shown that the weight of thyroid gland increases in rats treated with ketoconazole [461]. In another study designed to investigate the influence of ketoconazole on the basal and TSH-stimulated iodide uptake in the rat thyroid cells, concentration-based variations were observed. Ketoconazole appeared to increase the basal iodide uptake slightly at lower concentrations, while it sharply decreased the uptake below the basal levels at higher concentrations. Under TSH stimulation, the inhibitory effect of the drug were observed even at low concentrations [1207]. In contrast to these animal data, studies carried on in a limited number of euthyroid, healthy individuals, hypothyroid patients, and patients with thyrotoxicosis failed to provide any data suggesting a potential inhibitory effect of ketoconazole on thyroid functions [530, 531]. These data suggest that possible antithyroid effect of ketoconazole demands further investigation and close follow-up.

that is in oral administration

 

[lanky]

Oral ketoconazole has been demonstrated to lower plasma testosterone in man. Measurement of blood precursors of testosterone suggest that ketoconazole may have its effect inhibiting the 17,20-desmolase enzyme within the testis. To substantiate this, a series of in vitro experiments was conducted using the rat testis to determine where in the testosterone biosynthetic pathway ketoconazole has its effect. To accomplish this, an assay system to measure 17 alpha-hydroxylase, 17,20- desmolase, and 17 beta-hydroxysteroid dehydrogenase activities involved in the delta 4-testosterone biosynthetic pathway was developed. It was demonstrated from dose-response and time-course experiments that a dose of approximately 10 micrograms/ml ketoconazole was sufficient to inhibit in vitro testicular steroidogenesis. Using dosages between 10 and 300 micrograms/ml ketoconazole, a marked inhibition of both the 17 alpha-hydroxylase and the 17,20-desmolase activities occurred. Ketoconazole under these conditions had no effect on 17 beta- hydroxysteroid dehydrogenase activity. Ketoconazole also inhibited the increased activity of these enzymes induced by hCG (1 IU). These data confirm the observation that in vitro ketoconazole has a direct inhibitory effect on 17,20-desmolase activity. These results further suggest that ketoconazole has more than one site of action in inhibiting testosterone biosynthesis in the testis and may indeed be a suitable agent for the treatment of patients with disseminated prostate cancer.

 

[macrophage69alpha]

nizoral works topically, by blocking the AR in the scalp. Its not perfect but it does afford some protection. it could be better formulated for this purpose. However applying to warm wet scalp and leaving in for 3-5 minutes does have decent effect.

there are other anti-androgens that can be used topically that may be better suited, however formulation and base carrier are lacking at this time.

expect that they will develop a SARM, oral or injectable, that will eventually address this issue. big pharma would be stupid to not be looking at this (though they would also be stupid to let anyone know)

 

[Jon79]

Mac you ever get a chance to sleep bro

 

[doublebicep]

this stuff sounds like snake oil. think about it. shampoo is on your hair and scalp a matter of seconds before you rinse it down the drain.

dont see it can possibly keep your hair from falling out. can it magically absorb into your scalp for the few seconds you use it and stop hair loss? now propecia, which is taken internally or rogain, which is left on the scalp, could be effective.

shampoo is soap. wont stop your hair from falling out. wont turn your fine hair into a full head of hair. wont change unruly locks into a manageable head of hair. we are all suckered in by marketing.

You are correct, I doubt if a few seconds would have much of an effect.
Every day and leave it sit on your scalp for 4-5 minutes. I put it on, shave, and then shower. Ketoconozole has been shown to inhibit the synthesis of DHT by preventing some pathways of steroid synthesis.

I agree with others in this thread, us a high quality conditioner. I like Aussie for dry / damaged hair.

 

[macrophage69alpha]

You are correct, I doubt if a few seconds would have much of an effect.
Every day and leave it sit on your scalp for 4-5 minutes. I put it on, shave, and then shower.

 

[glennds]

live and learn.

 

[macrophage69alpha]

Mac you ever get a chance to sleep bro