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A phosphodiesterase type 5 inhibitor is a compound that blocks the degradation of phosphodiesterase type 5 on cyclic GMP in the smooth muscle cells lining of the blood vessels; which supplies the corpus cavernosum of the penis with blood flow. PDE-5 Ihibitiors such as Cialis are used in the treatment of erectile dysfunction, and were the first effective oral treatment available for this specific condition. PDE5 is also located in the arterial wall smooth muscle within the lungs, PDE5 inhibitors have also been used for the treatment of pulmonary hypertension, a disease in which blood vessels in the lungs become overflowed with fluid, usually due to the failure of the left ventricle of the heart. PDE5 inhibitors are clinically indicated for the treatment of erectile dysfunction. PDE5 inhibitors are primarily metabolized by the cytochrome P450 enzyme CYP3A4. The potential exists for adverse drug interactions with other drugs which inhibit or induce CYP3A4, including HIV protease inhibitors, ketoconazole, itraconazole, and other anti-hypertensive drugs such as Nitro-spray since it WILL lower blood pressure, which may result in a fatal drop of blood pressure. Taking PDE-5 Inhibitors with grapefruit juice or naringin will also prolong the effect of them, as grapefruit extract inhibits that enzyme from any other action but what is at state. (Adv. Cycl. Nucl. Res. 5:195-211, 1975.) Till this day, Sildenafil Citrate aka Viagra is the most popular PDE5 inhibitor, it was originally discovered during the search of a novel treatment for severe heart spasms. Studies in 2002 explored its potential for increasing the production of neurons after one has suffered as stroke. (Biochim. Biophys. Acta 284:220-226, 1972.)
Read the reast of my Article here ------> - Need To Build Muscle Inc. Official Blog
Read the reast of my Article here ------> - Need To Build Muscle Inc. Official Blog
