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Exemestane is a steroidal suicidal Type 1 irreversible aromatase inhibitor. It was originally created for breast cancer patients to block estradiol from creating more onceogenes. These same onceogenes are responsible for the growth of tumors and cancer cells. It’s a naturally occurring substance from androstenedione which makes it very similar to formestane, one can call them brothers if they would like. Its steroid skeleton is comprised of of an ethyl group on C6 making it similar to Boldenone, similar to that of ATD. It’s a newer generation AI which shows lots of promising potential as it does not abuse cholesterol as bad as other AI’s have been reported to do so along positive effects on bone mineral density. It also does not lower IGF levels which pretty much all other AI’s with the exception of formestane (raises IGF) lowers them. Since Exemestane is a steroidal AI, it does have some androgenic properties which can lead to some minor strength and size gain along an increase in masculinity. The byproduct from the liver called 17-hydroxyexemestane is a metabolite which is created by the reduction of the 17-oxo group by way of the 17-beta-hydroxysteroid dehydrogenase which is responsible for its potent anti-estrogenic properties. This is the same metabolite believed to be responsible for the protection and growth of bone cells. Studies suggest Exemestane will block circulating estrogen up to 85% in women and 65% in men within a 12 hour span. When exemestane reaches full blood plasma concentration within the blood, it will block up to 98% of estrogen which means its POTENT. Based on a couple of studies I have read the only AI that can be taken with Novladex to reduce the estrogen that comes from increased testosterone would be Exemestane. Novladex inhibits the effectiveness of arimadex and other AI’s based on this study: J Steroid Biochem Mol Biol. 2001 Dec;79(1-5):85-91. I present the study to you good bros so you see that I am not trying pull the wool over your eyes. The suggested use of Aromasin/Exemestane is 25mg to see the 20% decrease in SHBG, 65% decrease in estradiol, and 60% increase in total/ 117% in free testosterone. The estrogen suppression rate for exemestane can vary from 85% for estradiol (E2) to 95% for estrone (E1). Exemestane reaches peak plasma concentrations within 2 hours following the oral administration of a 25 mg dose. The biological life of the drug is between 24 and 30 hours, most will say 27 hours. This is significant since it has a much shorter half life than for the non-steroidal inhibitors. A single oral dose of 25 milligrams of exemestane causes a relatively long-lasting reduction in plasma and urinary estrogen levels, with maximal suppression occurring approximately 2 to 3 days after dosing and persists for about 4 to 5 days.It has been shown that 25 milligrams of exemestane is basically just as effective as 50 milligrams at suppressing estrogen, raising testosterone levels, and levels of IGF. It is therefore unnecessary to go higher in doses than 25 milligrams per day. Due to the active life of the compound exemestane should be administered roughly once every twenty-four hours. It has been documented that 2.5mgs will be sufficient for treatment but most pharmaceutical companies will only produce the
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Needtogetaas does suicidal aromatase inhibitor Exemestane,Aromasin. Need To Build Muscle Inc. Official Blog
Read the full Article here
Needtogetaas does suicidal aromatase inhibitor Exemestane,Aromasin. Need To Build Muscle Inc. Official Blog
