L-Ornithine Powder

[2supreme]

Does anyone know of a manufacturer for L-ornithine in powder form? Most companies sell it in tablet or capsule form alone or with L-arginine. Twinlab used to sell it in powder form, but have stopped production. The only manufacturer that I could find that is still producing is Source Naturals. Does anyone know the reliability of this company's products?

Thanks.

 

[anthrax]

Why are you looking at L-ornithine ?

I thought it was almost useless

 

[2supreme]

I should have been a bit more specific...

I'm actually looking for ornithine alpha-ketoglutarate (OKG) in powder form.

From www.supplementwatch.com-

Theory: OKG has been used to treat patients suffering from burns, surgery, malnutrition and other trauma. Although the precise mechanism is unknown, OKG treatment decreases muscle protein catabolism (breakdown) and/or increases protein synthesis, in addition to promoting wound healing. OKG may promote the secretion of anabolic hormones such as insulin and growth hormone and increase amino acid metabolism (glutamine & arginine), which may help explain some of the clinical findings. Scientific Support Arginine and ornithine are precursors of nitric oxide and polyamines, respectively -metabolites which participate in a number of metabolic functions. OKG supplements have been shown to promote growth hormone and insulin secretion with anabolic effects in postoperative patients. Their intermediary metabolites (glutamine & proline) may also have beneficial effects in promoting recovery from trauma. In animal studies, OKG supplementation increases levels of arginine and glutamine in skeletal muscles and stimulates immune system function compared to animals not receiving OKG. The immunomodulatory properties found with OKG suggest that it may enhance host-defense mechanisms, particularly during injury and acute stress

OKG supplements (15 grams per day for 5 months) have been shown to improve growth rates in small children. The OKG supplements resulted in elevated concentrations of anabolic (growth) hormones and amino acid metabolites, including insulin-like growth factor 1 (IGF1), glutamine and glutamate. In another study of healthy men, OKG given at 10 grams per day resulted in a 20-30% elevation in insulin (another anabolic hormone), which were not observed with supplementation of either ornithine or alpha-ketoglutarate alone.

A test tube study found that OKG induces a significant increase in growth of human fibroblasts – cells with similarities to muscle fiber cells. This effect was dose-dependent, meaning that a more pronounced growth effect was noted with increasing levels of OKG (but not with increasing levels of ornithine or alpha-ketoglutarate alone).

In one study, the anti-catabolic effects of OKG were investigated in 14 multiple trauma patients who were highly catabolic and hyper-metabolic. One group of subjects received 20 grams of OKG per day and showed a significant increase in protein turnover as well as a an increase in blood levels of insulin, growth hormone, and free amino acids (glutamine, proline and ornithine) compared to subjects not receiving OKG supplements.

Safety: No apparent side effects have been noted with OKG supplementation at the doses studied (10-15 grams/day), although there have been anecdotal reports of increased appetite – perhaps owing to elevated insulin levels (??).

Dr. Michael Colgan reports similar information in his book Optimum Sports Nutrition.

Also, an acquaintance who is a doctor from Sloan-Kettering and who has performed research on OKG and its effect on the release of HGH has suggested 10-15 grams per day.

Again, info on a reputable company that is selling OKG in powdered form would be appreciated.

 

[anthrax]

You may find something interesting here

 

[2supreme]

thanks