In my own experience I went from a body part split to a Westside program. I feel the more integrated full body approach these types of training methods have can in fact enhance your appearance. There's a couple things to remember:
You're going to be strength training, so that's your first priority. Don't sweat it if you think you're losing a little symmetry or detail. Once you go back it'll return with a few weeks of steady training. And it will return faster than you got it because the 5x5 will make you more physically fit.
In the meantime, you can train any lagging parts after you finish your planned workout with a few higher rep sets. You'll be surprised how much pump you can get with just 2-3 x10 after pre-exhausting them through your compound lifts.
And, of course, diet is still key. Keep things on an even keel and you'll be good to go.