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None at all. All is cool. It's hard to tell how people are really saying something by looking at "text". It's not the same as verbal "audio" communication.
HRT for women?
- Thread starter Smokescreen
- Start date
None at all. All is cool. It's hard to tell how people are really saying something by looking at "text". It's not the same as verbal "audio" communication.
XMAN.
New member
exactly the subject is about women producing an excess T and convert most of it to E or at least that how it looks like from AI's use to breast cancer and don't tell me where i got this from all the pharmacist in my neighborhood says so and just google it and u'll see tons of studies and article on it and it's real purpose which is not for BB.
the purpose of this discussion is just to learn about the female endocrine system and if test can be used for their hrt in an enough amount and let it convert to E naturally instead of supplementing E alone and put an old lady at great risks of high E without high T at the same time cuz high androgens protects a woman against breast cancer.
the person in my mind is my Mother plus some female trainees in my gym in my neighborhood.
thx for ur replies bro
True. Anyway, I think the confusion is thinking that women develop estrogen the same way men do.
Everything is the yin and yang --there's always a little of the opposite in everything. Case in point, the ovaries produce estrogen and a teeny bit of testosterone. The testicles produce testosterone and a teeny amount of estrogen. When enormous amounts of T are added to the mix, it gets wacky --i.e. aromatization. The HPTA is the hyperpituitary TESTICUlAR axis.
But everything works to maintain balance and women do have SHBG. When your wife added proviron it lowered estrogen, though I think the test was a crapshoot. By having extra test the body may suppress what it has but why would you want to suppress the tiny bit of test a women produces? SInce proviron is DHT it won;t regester as T but it will add androgenic qualities -- maybe too much. Odd desision of your docs part but there's some logic to it.
XMAN.
New member
after a long debate with Nelson 
i came up by coincidence on an article about Aromasin(exemestane) which explains that the main source of estro for women change after menopause and that's why AI's work for them so in general for young females Nelson was right but things changes after menopause. here's the article :
Exemestane is an oral steroidal aromatase inhibitor (but also known uniquely as an aromatase inactivator) used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. An aim in the treatment of hormone-receptor-positive patients in preventing recurrence is to lower estrogen levels that this breast cancer thrives on.
The main source of estrogen is the ovaries in premenopausal women, while in post-menopausal women most of the body's estrogen is produced in the adrenal gland from the conversion of androgens into estrogen by the aromatase enzyme. Exemestane is an irreversible, steroidal aromatase inactivator, structurally related to the natural substrate androstenedione. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as "suicide inhibition." In other words, Exemestane, by being structurally similar to the target of the enzymes, permanently binds to those enzymes, thereby preventing them from ever completing their task of converting androgens into estrogens.
The estrogen suppression rate for exemestane varies from 85% for estradiol (E2) to 95% for estrone (E1).
Exemestane is indicated for the adjuvant treatment of postmenopausal women with estrogen-receptor positive early breast cancer who have received two to three years of tamoxifen and are switched to it for completion of a total of five consecutive years of adjuvant hormonal therapy.
Exemestane is indicated for the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.
i came up by coincidence on an article about Aromasin(exemestane) which explains that the main source of estro for women change after menopause and that's why AI's work for them so in general for young females Nelson was right but things changes after menopause. here's the article :Exemestane is an oral steroidal aromatase inhibitor (but also known uniquely as an aromatase inactivator) used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. An aim in the treatment of hormone-receptor-positive patients in preventing recurrence is to lower estrogen levels that this breast cancer thrives on.
The main source of estrogen is the ovaries in premenopausal women, while in post-menopausal women most of the body's estrogen is produced in the adrenal gland from the conversion of androgens into estrogen by the aromatase enzyme. Exemestane is an irreversible, steroidal aromatase inactivator, structurally related to the natural substrate androstenedione. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as "suicide inhibition." In other words, Exemestane, by being structurally similar to the target of the enzymes, permanently binds to those enzymes, thereby preventing them from ever completing their task of converting androgens into estrogens.
The estrogen suppression rate for exemestane varies from 85% for estradiol (E2) to 95% for estrone (E1).
Exemestane is indicated for the adjuvant treatment of postmenopausal women with estrogen-receptor positive early breast cancer who have received two to three years of tamoxifen and are switched to it for completion of a total of five consecutive years of adjuvant hormonal therapy.
Exemestane is indicated for the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.
after a long debate with Nelson
Exemestane is an oral steroidal aromatase inhibitor (but also known uniquely as an aromatase inactivator) used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. An aim in the treatment of hormone-receptor-positive patients in preventing recurrence is to lower estrogen levels that this breast cancer thrives on.
The main source of estrogen is the ovaries in premenopausal women, while in post-menopausal women most of the body's estrogen is produced in the adrenal gland from the conversion of androgens into estrogen by the aromatase enzyme. Exemestane is an irreversible, steroidal aromatase inactivator, structurally related to the natural substrate androstenedione. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as "suicide inhibition." In other words, Exemestane, by being structurally similar to the target of the enzymes, permanently binds to those enzymes, thereby preventing them from ever completing their task of converting androgens into estrogens.
The estrogen suppression rate for exemestane varies from 85% for estradiol (E2) to 95% for estrone (E1).
Exemestane is indicated for the adjuvant treatment of postmenopausal women with estrogen-receptor positive early breast cancer who have received two to three years of tamoxifen and are switched to it for completion of a total of five consecutive years of adjuvant hormonal therapy.
Exemestane is indicated for the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.
Yes, good post, though I didn't even consider post menapausal women for the reason that most have LOW estro and need replacement so conversion isn't a big factor for them.
You must spread some Karma around (ie give karma to other members too) before giving it to Nelson Montana again.
