benevolent............Probably the best choice of insulin sensitizer would be Avandia, a so called thiazolidinedione. These drugs are superior to ALA in their ability to shuttle glucose into the cell, and even more importantly they upregulate glycogen synthase. The drawback to ALA is that it may improve glucose transport into the cell, but if the glucose cannot be stored as glycogen, transport will cease. Insulin itself upregulates glycogen synthase.
Also, the insulin resistance associated with anabolic steroid use is thought to be a result of impaired glycogen synthase. ALA won't help this but a thiazolidinedione would. ALA is fine as an OTC drug, but it really pales in comparison to some of the other things out there. The other plus to ALA besides its availability is the apparent lack of side effects.
Not only do the thiazolidinediones enhance glucose transport into cells, they increase amino acid uptake as well. These drugs induce a 4 to 5-fold increase in the rate of amino acid uptake for a given plasma level of insulin. That is impressive.
I'll be interested to hear your final opinion on the Supra product, and thanks for the compliment.
Also, the insulin resistance associated with anabolic steroid use is thought to be a result of impaired glycogen synthase. ALA won't help this but a thiazolidinedione would. ALA is fine as an OTC drug, but it really pales in comparison to some of the other things out there. The other plus to ALA besides its availability is the apparent lack of side effects.
Not only do the thiazolidinediones enhance glucose transport into cells, they increase amino acid uptake as well. These drugs induce a 4 to 5-fold increase in the rate of amino acid uptake for a given plasma level of insulin. That is impressive.
I'll be interested to hear your final opinion on the Supra product, and thanks for the compliment.