HELP! Gyno and Saw Palmetto

[ColdCut]

But SP without the use of AS is okay? im not on any cycle now, and dont think i will be for a long time to come, no$

 

[pharmguy]

saw palmetto is IMO a weak 5-ar inhibitor at best and would be a highly unlikely culprit in causing gyno through DHT suprresion. One would have to take 100's of pills a day to get this result. It has never done much for my hairloss probs in the past.....

 

[ColdCut]

saw palmetto is IMO a weak 5-ar inhibitor at best and would be a highly unlikely culprit in causing gyno through DHT suprresion. One would have to take 100's of pills a day to get this result. It has never done much for my hairloss probs in the past.....

thats weird, it has cut my shedding to 1/2 what it was a few weeks ago, but i also agree its very weak compared to propecia or avodart (dutasteride)

 

[twistedneck]

Fuck Nizoral - It was 'the shit' on my hair but I think it fucked up my test levels along with the spiro and azelaic acid i was using. here are some snipets from studies on Nizoral.. btw, thanks Paul Allen for letting me know.. i thought i just helped the skin layer! i was using this 2% shit for body soap!

Active ingredient in Nizoral (Ketoconazole), taken in tablet form, has been shown to lower serum testosterone. The effect has been compared to that of minoxidil 2%. It is available in 1% form over-the-counter or in 2% form as a prescription.

AUC(0,10) for testosterone was 42% lower than control after ketoconazole administration

The fungicide ketoconazole has been shown to lower serum testosterone levels and alter both gonadal synthesis and hepatic inactivation of testosterone.

The changes in serum testosterone levels could be explained by decreased gonadal synthesis of testosterone

Total and free plasma testosterone fell to levels 60% below basal within 4-8 h (P less than 0.02 in all) and then returned to control concentrations by 24 h after drug administration. The transient alterations of plasma testosterone correlated well with ketoconazole blood levels, which peaked at 2 h and fell exponentially thereafter. A compensatory increase in plasma LH at 24 h in the drug but not placebo group was consistent with the decrease in plasma testosterone.

HDK acts on cytochrome P-450 dependent 14 demethylation and decreases conversion of lanosterol to cholesterol, blocks 17,20-desmolase resulting in a decrease in serum testosterone, androstenedione, & dehydroepiandrosterone (DHEA).

Doses of 30 mg/kg twice daily of ketoconazole alone depressed plasma testosterone levels by approximately 75% to a nadir of 0.47 +/- 0.08 (SE) ng/ml on day 20 (P less than 0.001 versus basal). This effect of ketoconazole was exerted directly at the testicular level since plasma luteinizing hormone levels were not suppressed