hitmeoff said:
Fonz, explain this abstract to me in plain english:
Abstract: unassigned Both enantiomers of 3,4 methylenedioxymethamphetamine (MDMA) competitively inhibited 5-hydroxytryptamine (5-HT) catabolism by rat brain MAO-A. A mixed type of inhibition by MDMA was observed for phenethylamine catabolism by MAO-B for both optical antipodes. When the MAO inhibitory properties of fenfluramine (FEN) and fluoxetine (FLUOX) were compared with those of MDMA, the rank order potency of these drugs was MDMA>FLUOX>FEN for MAO-A inhibition and FLUOX>MDMA>FEN for MAO-B inhibition. MDMA produced a preferential inhibition of MAO-A, which should increase extracellular 5-HT; this may explain its high toxicity potential. FLUOX showed an inhibition of MAO-B, which may increase the intracellular content of 5-HT and may contribute to its therapeutic potential. FEN appears to be a poor inhibitor of both MAO-A and MAO-B.
This is from a related study of effect of Prozac on E.
But in anycase, if ALA is neuroprotector, then you agree that, with enough knowledge, and responsibility, a person could use E relatively safely.
Not taking your Prozac and your ALA while on E, i think is like not taking you ALA or Milk Thistle when your running ABombs.
Im sure heavy, long term Anadrol use, without proper supplementation can be as bad in the long run as consistant and irresposible E use. Thats my bottom line.
Interesting.
What E does is put your CNS in over-drive and also plays
a role in your serotonergic metabolism.(You feel happy
and elated while on E).
The prozac would combat the serotonergic come down.
E can play havoc with your 5-HT levels.
Now, increased oxygen consumption because of CNS stimulation
produces free radicals that damage neurons. This prozac can not combat. Only ALA can as it is a very potent anti-oxidant.
Mixing ALA and Prozac(OR better yet 5-HTP. Just safer IMO)
with E would help prevent any potential damage.
It sounds good on paper. Don't know about real life though.
I don't condone E use, but if I did do E, I would DEFINATELY
use ALA and 5-HTP.
Fonz