No offense, but for your friend's sake, I'd recommend that you get him to invest some money with a more knowledgeable trainer.
16-12-10-8 and 4x10 are basically bodybuilding methods. So if you're genetically gifted you can get away with that stuff, but it is far from optimal for training explosive athletes.
I'm sure Oregon had a better program than many NFL programs. Seriously.
Snatches and Cleans are good.
Heavy pressing and rowing (< 6 reps) as well as lighter weights for explosive reps.
It depends what his strength levels are at right now.
Mainly focus on the posterior chain. Especially since he's a safety.
Squats, Deadlifts, Lunges, Step-ups, Glute ham raises, reverse hyperextensions, power versions of olympic lifts and their variants (pulls, power shrugs).
Also for injury prevention--
4-way neck machine, sound rotator cuff program, increase hamstring and glute strength, and VMO development for patella tracking.
4 day split would be good. 2 upper, 2 lower.
Lower would be 1 oly, 1 squat/deadlift, 1 unilateral leg movement, hip extension/hamstring stuff
Upper would be presses, rows, chins & dips. One strength & one explosive day.
There's definitely more complicated ways of training and planning, but it's a little late for that.
Honestly, you should probably just focus on injury prevention and hope he has the actual football skills.