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Drug C75 better than DNP?
- Thread starter brownpaperbag04
- Start date
Lao Tzu
New member
a company called millenium is working on a drug that blocks the enzyme carboxypeptidase, which will inhibit fat building in the body. However, they just started Phase 1 testing. So there is no telling if the drug will ever come to market.
sucks to be our generation. in 20 years drugs that boost metabolism by 50%, cut appetite by 50% and inhibit fat storage will all be on the market.
I'm still fully convinced that the obesity epidemic will end in under 50 years. Our grandkids will listen to stories about the obesity epidemic with all the fears of getting it and all the non-working cures being pimped out for it the same way we listened to our parents talk about the Polio epidemic.
sucks to be our generation. in 20 years drugs that boost metabolism by 50%, cut appetite by 50% and inhibit fat storage will all be on the market.
I'm still fully convinced that the obesity epidemic will end in under 50 years. Our grandkids will listen to stories about the obesity epidemic with all the fears of getting it and all the non-working cures being pimped out for it the same way we listened to our parents talk about the Polio epidemic.
Its a hard thing to find something that actually works......my chem teacher was a pharmacokinetist and was telling me about what he saw when he did his work. He swears like 99% of the drugs they come up with dont work. On paper and in theory, they work, but once in the body, they end up worthless.
The good thing about C75, its a synthetic that has worked in animals with no sides.....at least it works well in mice, most drugs dont even make it that far without fucking up.
If i can get a few people i know to help me make it, i might be crazy enough to take the stuff, even without the 10 years the FDA takes to approve shit....
The good thing about C75, its a synthetic that has worked in animals with no sides.....at least it works well in mice, most drugs dont even make it that far without fucking up.
If i can get a few people i know to help me make it, i might be crazy enough to take the stuff, even without the 10 years the FDA takes to approve shit....
The blocking of fatty acid synthesis elevates levels of malonyl-CoA, this is believed to be key in apoptosis of malignant cells and key in appitite supression and keeping your body out of starvation mode. In the testing done, FFA pools dropped by some %50.
Honestly, i feel C75 might be better for loosing fat you already have than the one Wakil is working on becasue you CAN have a good caloric deficit while still burning fat at maximum capacity and not worry about going catabolic.
Wakil's would be good for maintaining weight or bulking so where you can eat all the time and not get fat.
Soon, we will be able to focus on perfecting our musculature and not spend every day worrying about dealing with fat (thats me for ya, been overweight for a ling time and its a constant struggle).....
Honestly, i feel C75 might be better for loosing fat you already have than the one Wakil is working on becasue you CAN have a good caloric deficit while still burning fat at maximum capacity and not worry about going catabolic.
Wakil's would be good for maintaining weight or bulking so where you can eat all the time and not get fat.
Soon, we will be able to focus on perfecting our musculature and not spend every day worrying about dealing with fat (thats me for ya, been overweight for a ling time and its a constant struggle).....
There's just one problem.
Our undertsanding of the human biological machinery is very poor.
While you might block one thing, two things might unravel that you don't want.
Remember, he is testing his compound on rats.
Also, thermodynamically speaking, this compound makes no sense. A 50% increase in BMR?
OK...fine....I'll give him the benefit of the doubt.
How is this achieved. How is the energy dissipated?
Energy doesn't simply dissapear, it has to go somewhere. Hence why I said, the core body temperature has to go up in order to off-set the increase in BMR.
The only real way to achieve this is to increase the amount of BAT adults have(roughly 70g). If one were able to increase the BAT
possesed by adults, non-shivering thermogenesis would sky-rocket and you would dissipate a LOT of calories w/o moving.
But this topic is rather complicated and is in the process of being experimented with in VIVO. Not with rats. Beta-3's, possess the ability to stimulate BAT thermogenesis. i.e. Mazindol.
Fonz
Our undertsanding of the human biological machinery is very poor.
While you might block one thing, two things might unravel that you don't want.
Remember, he is testing his compound on rats.
Also, thermodynamically speaking, this compound makes no sense. A 50% increase in BMR?
OK...fine....I'll give him the benefit of the doubt.
How is this achieved. How is the energy dissipated?
Energy doesn't simply dissapear, it has to go somewhere. Hence why I said, the core body temperature has to go up in order to off-set the increase in BMR.
The only real way to achieve this is to increase the amount of BAT adults have(roughly 70g). If one were able to increase the BAT
possesed by adults, non-shivering thermogenesis would sky-rocket and you would dissipate a LOT of calories w/o moving.
But this topic is rather complicated and is in the process of being experimented with in VIVO. Not with rats. Beta-3's, possess the ability to stimulate BAT thermogenesis. i.e. Mazindol.
Fonz
The test have been done in vivo and in vitro on lab animals and in human cancer cells. From the tests done so far, there were zero side effects. I believe this is becasue FAS is only found and active in the liver, adipose tissue, and in the brain as a regulator of appitite and such. An inhibitor of FAS should only be active in those organs, and that is what was observed.....the only "side effects" in the testing against cancer was weightloss (drastic) and extreme appitite supression. So it seems this drug can have a limited scope and target tissues...
I dont know where the %50 increase in BMR came from, but i dont see why it isnt possible.....DNP increases metabolism to that amount without CNS stimulation, (but releases the H+ as entropy).....what i would question is where the ATP being made is going to be expended?????
So far, it seems as if malonyl-CoA is the key......with inhibition of fatty acid, this molecule (also plays a part in fatty acid synthesis) builds up and acts as FFA in the brain telling the body its well fed and metabolism can proceed at %100. The doctors feel that the molecule also might act in anotherway to increase metabolism.
I agree with you Fonz, im not saying its a magic pill, but what has been observed shows great promise. All the research is geared toward a drug for humans, a chemicaly stabe inhibitor, completly synthetic. Wakil is working on a human drug minus the appitite supression (i dont know how hes going to do it, it seems to be key in triggering weight loss). Ive given up on brown adipose tissue manipulation, it just seemed too out of reach....unless you have things to share....!
I guess the combination of a big caloric deficit and a metabolism at %100 (no starvation mode is very key in this) could give results that are as amazing as a %50 increase in BMR......i mena thats why diets are only partially effective....when you have a caloric defecit, your body senses this and slows metabolism.
I dont know where the %50 increase in BMR came from, but i dont see why it isnt possible.....DNP increases metabolism to that amount without CNS stimulation, (but releases the H+ as entropy).....what i would question is where the ATP being made is going to be expended?????
So far, it seems as if malonyl-CoA is the key......with inhibition of fatty acid, this molecule (also plays a part in fatty acid synthesis) builds up and acts as FFA in the brain telling the body its well fed and metabolism can proceed at %100. The doctors feel that the molecule also might act in anotherway to increase metabolism.
I agree with you Fonz, im not saying its a magic pill, but what has been observed shows great promise. All the research is geared toward a drug for humans, a chemicaly stabe inhibitor, completly synthetic. Wakil is working on a human drug minus the appitite supression (i dont know how hes going to do it, it seems to be key in triggering weight loss). Ive given up on brown adipose tissue manipulation, it just seemed too out of reach....unless you have things to share....!
I guess the combination of a big caloric deficit and a metabolism at %100 (no starvation mode is very key in this) could give results that are as amazing as a %50 increase in BMR......i mena thats why diets are only partially effective....when you have a caloric defecit, your body senses this and slows metabolism.
nikolai_bolkov
New member
Btw, did anyone read the article about how human's are very comporable biologically to mice, thus strengthening research done on mice?
