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drinking winstrol

Are you planning ED or EOD? Technically you can drink it because it is water based, but it seems a bit of a waste. Why put your body through the extra liver pass/stress in order to avoid a little pin poke? I would IM it unless you are in an absolute hurry than drink it.
 
would it make a difference if it was oil based? My friend did that the other day because he didnt want to inject again that day. that must have tasted really bad.
 
solidspine, I reckoned it would be better to divide the dose, 25 mg twice a day to have a more even blood concentration.
 
EURI.....Its a 17akl based drug...takes the same path whether you drink it or shoot it.....stress is irrelevant in this case...liver is stressed less with one dose....best in AM.....Iam told...
 
It is 17aa, but when taken orally it goes through two liver passes to get into your system which leads to more stress. IM only goes through one pass, albeit still taxing the liver... but lesser of the two. Also not to mention you need roughly 50% more orally, so to equal a standard 50mg EOD IM dosage, you need to take 37.5mg ED orally. Personally, I would shoot it if given the two options.
 
Euriskan said:
It is 17aa, but when taken orally it goes through two liver passes to get into your system which leads to more stress. IM only goes through one pass, albeit still taxing the liver... but lesser of the two. Also not to mention you need roughly 50% more orally, so to equal a standard 50mg EOD IM dosage, you need to take 37.5mg ED orally. Personally, I would shoot it if given the two options.

Don't you mean that you need 75 mg oraly?
 
I normally do EOD injections so 50mgEOD=25mgED, so you would need 37.5mg ED orally. So if you are doing 50mgED IM, than yes you would need 75mgED orally... which just seems like a lot of stress on your liver. Either way, make sure you have proper liver protection.
 
gotgame: I don't think it makes any difference if it's oil based. It's still a 17aa. I've been taking oily winny orally for a couple of weeks now and it seems to be working (i.e. joints are drying up, which sucks).
 
Euriskan said:
Are you planning ED or EOD? Technically you can drink it because it is water based, but it seems a bit of a waste. Why put your body through the extra liver pass/stress in order to avoid a little pin poke? I would IM it unless you are in an absolute hurry than drink it.


so then technicaly a person can drink test suspension because it also is water based?

and about the exta liver stress, do you have studies or did you hear this from a friend?
 
Sorry, Winny is 17aa so it can be taken orally... you wont get much out of test suspension orally because it isn't 17aa. I have heard of women who drink winny in order to avoid problems with fakes/switches.

It is widely known that 17aa are hard on your liver, and since taken orally requires two liver passes than that just adds to the stress. To answer your question, no I didn't "hear it from a friend" just did some research before using it... something you may want to do! Or just read a good drug profile.
 
couple of questions

I have have never taken winstol and would like to take some coming up this wrestling season. But I have talked with some of my friends and they swear it will do a number on my joints. I don't have the best joints to start with and don't want to hurt them even more by taking this stuff. But I also have other friends who love it and get great results. I was also wondering, it might be a long shot but if you inject or take it orally will it effect you differently in the joints, will one be worse than the other. Also if any body knows what is the best thing for wrestlers to take to get stronger with out water retention and not get so pumped during the match please let me know. Thanks:fro:
 
Re: couple of questions

tapoutm said:
I have have never taken winstol and would like to take some coming up this wrestling season. But I have talked with some of my friends and they swear it will do a number on my joints. I don't have the best joints to start with and don't want to hurt them even more by taking this stuff. But I also have other friends who love it and get great results. I was also wondering, it might be a long shot but if you inject or take it orally will it effect you differently in the joints, will one be worse than the other. Also if any body knows what is the best thing for wrestlers to take to get stronger with out water retention and not get so pumped during the match please let me know. Thanks:fro:

The joint problem can be alleviated by using it with deca (as many will do). But this can present problems if you are drug tested (being a collegiate athlete and all). What I would recommend would be something along the lines of a Anavar/EQ.

My compadre says you should just call me anyway you bonehead! ;) . See you later.
 
Euriskan said:

It is widely known that 17aa are hard on your liver, and since taken orally requires two liver passes than that just adds to the stress. To answer your question, no I didn't "hear it from a friend" just did some research before using it... something you may want to do! Or just read a good drug profile.

yes, 17aa are hard on the liver but injecting them won't make it any easier, 17aa are desgned so that they can survive the trip through the GI tract and then become active after passing through the liver (1st pass)
so injecting 17aa's won't make them active they still have to make the 1st pass through the liver

that's what my friend said anyway
 
Oral winstrol makes two liver passes, while injecting is already in your blood supply so it only makes one liver pass. Simple logic says two passes on the liver means more taxing on your system. It is also less effective, which means you have to take more orally to equal the same amount injected. Again, using simple logic more winny means harder on your system. Also injecting is more of a sustained release, which is why one can get by on 50EOD. Seems standard oral dosage is 50mg, split up 2xdaily. So your liver gets hit hard 2xdaily plus having to make 2 passes, where as with IM it is hit gradually and only one pass. I am not saying injecting isn't hard on you, but it is the lesser of two evils.
 
Euriskan said:
Oral winstrol makes two liver passes, while injecting is already in your blood supply so it only makes one liver pass. Simple logic says two passes on the liver means more taxing on your system. It is also less effective, which means you have to take more orally to equal the same amount injected. Again, using simple logic more winny means harder on your system. Also injecting is more of a sustained release, which is why one can get by on 50EOD. Seems standard oral dosage is 50mg, split up 2xdaily. So your liver gets hit hard 2xdaily plus having to make 2 passes, where as with IM it is hit gradually and only one pass. I am not saying injecting isn't hard on you, but it is the lesser of two evils.

Yeah but the pass through the liver is what activated teh stuff anyway....2 passes might activate mroe
 
Not sure about making that, but have read that oral winstrol is supposed to stimulate IGF-1 when taken in higer dosages i.e. 50mg daily.
 
Euriskan said:
Oral winstrol makes two liver passes, while injecting is already in your blood supply so it only makes one liver pass. Simple logic says two passes on the liver means more taxing on your system. It is also less effective, which means you have to take more orally to equal the same amount injected. Again, using simple logic more winny means harder on your system. Also injecting is more of a sustained release, which is why one can get by on 50EOD. Seems standard oral dosage is 50mg, split up 2xdaily. So your liver gets hit hard 2xdaily plus having to make 2 passes, where as with IM it is hit gradually and only one pass. I am not saying injecting isn't hard on you, but it is the lesser of two evils.

obviously you don't understand how 17aa's work, and don't give me any more BS about simple logic, it makes no differance wether you inject or swallow them, it will make the same # of passes through the liver. some people prefer to site inject because they believe in site injected growth.

Show me the proof that it is less taxing on the liver to inject winstrol and show me proof that it is 50% more effective to inject

If injecting 17aa's were realy 50% more effective as you say, and so much easier on the liver, don't you think everyone would be injecting orals?
especially expensive stuff like anavar as it would be very easy to convert to an injectable
 
I am not making this shit up bro, just came from doing research before ingesting anything. This isn't coming from a friend at the gym, hell listen to your friend... I have nothing to gain from trying to help out a stranger. Drink your winny if you want, I will stick the injecting and if they are tabs will take orally. There are advantages/disadvantages to both.

Show me the proof that it is less taxing on the liver to inject winstrol and show me proof that it is 50% more effective to inject

I would first recommend you check out:
http://www.google.com


http://www.t-mag.com/nation_articles/191stras.html
Q: There's this huge debate raging over whether or not you can "drink" your Winny-V. I know that because stanozolol is 17-AA'ed, I can use it orally. However, how much more or less effective is oral stanozolol over injected stanozolol? I hear that you need about twice as much stanozolol orally as you would injected to see similar results. How was this figure of doubling the dose orally determined?

A: There isn't a lot of great pharmacokinetic data in humans comparing oral to parenteral (injectable) stanozolol. So that idea of "if you use X amount by injection you need twice as much orally" is anecdotal and speculative at best. The best I could find is a study comparing the two methods of administration in dogs. My comments come after the abstract:

The effect of stanozolol on 15-nitrogen retention in the dog

Can J Vet Res 2000 Oct;64(4):246-8 (ISSN: 0830-9000)

Olson ME; Morck DW; Quinn KB [Find other articles with these Authors] Animal Health Unit and Gastrointestinal Sciences, University of Calgary, Alberta.

The objective of the study was to determine the influence of either oral or intramuscular administration of stanozolol on nitrogen retention in dogs by using a non-invasive 15N-amino acid tracer technique. Ten healthy, intact, adult male sled dogs received either stanozolol tablets, 2 mg/dog PO, q12h, for 25 days (Group 1, n = 5) or an intramuscular injection of 25 mg of stanozolol on Days 7, 14, 21, and 28 (Group 2, n = 5). A 15N amino acid (5.27 mmol) was infused intravenously into each dog on Day 0 (before stanozolol treatment) and on Day 31 (after stanozolol treatment). Urine was collected by catheterization from each animal 3 times daily for 3 consecutive days. The 15N-urea enrichment in urine was determined by high-resolution mass spectrometry and the total amount of urea in the urine was determined.

Both oral and injectable stanozolol resulted in significant (P < 0.05) increases in amino acid nitrogen retention compared to pretreatment values. Oral stanozolol increased nitrogen retention from 29.2 +/- 8.2% to 50.3 +/- 9.2%, while stanozolol injection increased nitrogen retention from 26.6 +/- 9.9% to 67.0 +/- 7.5%. The response to intramuscular administration was significantly greater than the response to the oral dosing regime. Stanozolol increases amino acid nitrogen retention in dogs, as has been previously observed in rats. This action of stanozolol may be beneficial in dogs under stress of surgical trauma and chronic disease.

Okay, so the oral dose was 28mg/week and the injected dose was 25mg/week. And the injected dose was far better at increasing nitrogen retention (67.0% versus 50.3%). This makes it about 33.2% better (roughly speaking), so if I extrapolate, it means to see the same effects as 25mg of injected stanozolol per week, you'd need to take about 38mg of it orally.

This isn't quite "twice the injected dose" and is, in fact, closer to 50% (52% or so actually). So if you assume the dog model is correct, or nearly so in other mammals like humans, you'd need about 50% more stanozolol orally than you would if you injected it. So if you used 50mg of injected Winstrol every other day, it would be a safe bet to assume 37.5mg of stanozolol used orally every day would provide a similar effect.


http://www.bodybuilding.com/fun/catq.htm
Question:
In your opinion, what is the best way to take Winny? Drinking the injectable aqueous solution or injecting it while varying the injection sites and does drinking the injectable aqueous solution result in the same amount of liver toxicity as the orals? BTW, I read your steroid profiles and I must compliment you on them. Nice work, Big Cat!!

Answer:
Ingesting will always give a lower yield than injecting, even with 17-alpha-alkykation. If you are drinking vials and you do a vial a day, you wouldn't note a whole lot of difference. Injecting is best for people wanting to use lower doses, they can inject once every other day. But people that take every day, would opt for oral in which case a vial (being the same compound as the tabs) is more value for money than the tabs. A single morning dose of 1 vial (50 mg) is the preferred use. Since I'm not one to recommend the pain of daily injections and I find the orals to be poor value for money, ingesting the vials is the best way to go in my opinion. At least if you go high dose.

Ingesting it means it makes two passes through the liver, when injecting only once. Obviously making a first pass makes ingesting more toxic than injecting, eventhough both compound are 17-alpha-alkylated. When ingesting I do not recommend use of Winstrol for longer than 6-8 weeks. If you go beyond six weeks its advised you get liver values tested on a regular basis. When injecting one could stretch use for 8-10 weeks, under the same prerequisite.
 
yeah thanks for replying back, I know you're not basing this whole arguement on an article from t-mag you are definately smarter than that ( I hope) and I know how to use google but thanks for the sugestion, kinda busy right now so I'll get back to this when I can
I was only jk about hearing this from a friend
 
I am not basing it on TMag article but read the study... you asked for something. To be honest it was hard for me to buy it at first, after all I am not a dog but the stuff I was taking had a dog on it. But in my real world experience, all things being equal i.e. training, diet, brand I saw better results injecting vs oral/drinking and I started out with oral winny. I am not saying oral is a waste because I saw results, but if I can get by on taking less and get better results than I will opt for injection. I have read that grapefruit, chewing and holding under tounge, upping the liver protectants will help with oral dosages. In the end will stick with IM if given the choice but you do what you have to do.
 
MrMcFraggle said:
I have heard from a couple of people that drank it that you should add some milk thistle daily to help with the liver issues.

milk thistle is a good idea for all 17-a steroids.
 
Euriskan said:
Are you planning ED or EOD? Technically you can drink it because it is water based, but it seems a bit of a waste. Why put your body through the extra liver pass/stress in order to avoid a little pin poke? I would IM it unless you are in an absolute hurry than drink it.
you cannot drink it because its water based you can drink it because its a 17 AA drug. Come on folks I know I have been gone awhile and no longer mod here but lets be accurate. Enough Misinformation! And to answer the post yes you can do that. I do not think its necessary but...you can
 
Quadsweep said:
you cannot drink it because its water based you can drink it because its a 17 AA drug. .............

^^ what he said

also re Milk Thistle, while it was the standard for a long time, recent meta-studies (study of studies) concluded that no benefit could be proven based on liver panel and other measures, and the risk of side effects could not be excluded. not a good risk/reward.

But, there's good science behind the use of rALA and NAC (n-aceylcystiene) for liver protection and regeneration.
 
Ok...if milk thistle is out can someone explain what that alternatives are....
rALA and NAC? Injecting Winny is quite literally a pain in the rear end....
I have take water based orally for a while with good results and have used milk thistle to help ease the stress on the liver....
however without doing labs i don't know how effective this is.....
there should be a sticky on this.....messing with your liver is no joke!
any words of wisdom will help....
bottom line.....what is the accepted liver helper?
 
Euriskan said:
\ It is also less effective, which means you have to take more orally to equal the same amount injected.

That is not true... it is equally as effective injected or swallowed, you show me Anywhere that disagrees with that
 
get456 said:
That is not true... it is equally as effective injected or swallowed, you show me Anywhere that disagrees with that


Can J Vet Res. 2000 October; 64(4): 246–248.
M E Olson, D W Morck, and K B Quinn
The effect of stanozolol on 15nitrogen retention in the dog.
The objective of the study was to determine the influence of either oral or intramuscular administration of stanozolol on nitrogen retention in dogs by using a non-invasive 15N-amino acid tracer technique. Ten healthy, intact, adult male sled dogs received either stanozolol tablets, 2 mg/dog PO, q12h, for 25 days (Group 1, n = 5) or an intramuscular injection of 25 mg of stanozolol on Days 7, 14, 21, and 28 (Group 2, n = 5). A 15N amino acid (5.27 mmol) was infused intravenously into each dog on Day 0 (before stanozolol treatment) and on Day 31 (after stanozolol treatment). Urine was collected by catheterization from each animal 3 times daily for 3 consecutive days. The 15N-urea enrichment in urine was determined by high-resolution mass spectrometry and the total amount of urea in the urine was determined. Both oral and injectable stanozolol resulted in significant (P < 0.05) increases in amino acid nitrogen retention compared to pretreatment values. Oral stanozolol increased nitrogen retention from 29.2 +/- 8.2% to 50.3 +/- 9.2%, while stanozolol injection increased nitrogen retention from 26.6 +/- 9.9% to 67.0 +/- 7.5%. The response to intramuscular administration was significantly greater than the response to the oral dosing regime. Stanozolol increases amino acid nitrogen retention in dogs, as has been previously observed in rats. This action of stanozolol may be beneficial in dogs under stress of surgical trauma and chronic disease.
 
So is Milk Thistle still a reliable aid to the liver against stress.....?
And if not - than what other Supps are available to aid in its stabilization and recovery?
 
motiondo said:
So is Milk Thistle still a reliable aid to the liver against stress.....?
And if not - than what other Supps are available to aid in its stabilization and recovery?
rALA and NAC - I'm sure there's others as well as brand combination products, but these are solid

re Milk Thistle:

MetaStudy

Conclusions. Milk thistle's efficacy is not established
http://www.ncbi.nlm.nih.gov/books/bv.fcgi?rid=hstat1.chapter.29128


The ironic fact is," notes Christian Gluud of the Copenhagen Trial Unit, Center for Clinical Intervention Research at the Copenhagen University Hospital, "that even though milk thistle and milk thistle extracts have been widely examined, we are still not in a situation where we can exclude a potential beneficial or harmful effect." http://www.sciencedaily.com/releases/2005/12/051219235348.htm
 
PBR said:
EURI.....Its a 17akl based drug...takes the same path whether you drink it or shoot it.....stress is irrelevant in this case...liver is stressed less with one dose....best in AM.....Iam told...
not true. When you inj it it saves one pass through the liver. Therefore it is slightly less stressful on the liver and the body uses more of the compound.
 
jumpmaster82 said:
not true. When you inj it it saves one pass through the liver. Therefore it is slightly less stressful on the liver and the body uses more of the compound.

^^ what he said

-
 
8and20 said:
Can J Vet Res. 2000 October; 64(4): 246–248.
M E Olson, D W Morck, and K B Quinn
The effect of stanozolol on 15nitrogen retention in the dog.

Oral stanozolol increased nitrogen retention from 29.2 +/- 8.2% to 50.3 +/- 9.2%, while stanozolol injection increased nitrogen retention from 26.6 +/- 9.9% to 67.0 +/- 7.5%.

So, 17%?

And I have to be honest that is the first study I've ever seen posted that was done on dogs and results being extrapolated to human application


:p
 
try not to swallow

Sublingual Absorption
Some drugs are taken as smaller tablets which are held in the mouth or under the tongue. These are buccal or sublingual dosage forms. Buccal tablets are often harder tablets (4 hour disintegration time), designed to dissolve slowly. Nitroglycerin, as a softer sublingual tablet (2 min disintegration time), may be used for the rapid relief of angina. This method is also used for some steroids such as testosterone and oxytocin. Nicotine containing chewing gum may be used for cigarette smoking replacement.
Advantages:
  1. First pass - The liver is by-passed thus there is no loss of drug by first pass effect for buccal administration. Bioavailability is higher.
  2. Rapid absorption - Because of the good blood supply to the area absorption is usually quite rapid.
  3. Drug stability - pH in mouth relatively neutral (cf. stomach - acidic). Thus a drug may be more stable.
Disadvantages:
  1. Holding the dose in the mouth is inconvenient. If any is swallowed that portion must be treated as an oral dose and subject to first pass metabolism.
  2. Only small doses can be accommodated easily.
 
not true. When you inj it it saves one pass through the liver. Therefore it is slightly less stressful on the liver and the body uses more of the compound.

you know what? when I eat the winstrol, my stomach gets upset and I bloat up with vile smelling gas. I assume this is bc my liver is working overtime dealing with two passes. when I pin winstrol, I dont get the gastrointestinal cramps and gas but have to deal with the painful injections, its right up there with test suspension. Ive had no problems with blood work, everythings fine but its definitely a love/hate relationship with winny
 
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