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rub out the easy one before you get jiggy with the lady, best remedy for PE there is, and cheap!
Dapoxetine...don't be a 3 pump chump!!!
- Thread starter John Juan
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rub out the easy one before you get jiggy with the lady, best remedy for PE there is, and cheap!
John Juan
New member
[Dapoxetine (Priligy): on demand treatment of premature ejaculation].
Authors
Andrianne R.
Journal
Rev Med Liege. 2013 Dec;68(12):655-60. Article in French.
Affiliation
Abstract
Premature ejaculation (PE) is a common sexual dysfunction, affecting approximately 20-24% of men. Managing PE has been a challenge for physicians and psycho-sexologists as well because no drug for PE has been approved by European (EMA) or U.S. (FDA) drug agencies. Over the past decade, clinical evidence has emerged indicating a beneficial effect of selective serotonin reuptake inhibitors (SSRIs), tramadol, penile anesthesia and, in some cases, inhibitors of phosphodiesterase type 5 for the treatment of men with PE. A psycho-sexological care helps support. In spite of their efficacy, adverse effects represent the major concern for the chronic use of SSRIs in patients with PE and they may prompt discontinuation from therapy. Dapoxetine, marketed as Priligy, is the first compound developed specially for the treatment of PE, on demand before intercourse. Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin's action at the postsynaptic cleft, and as a consequence promoting ejaculatory delay. Dapoxetine is quickly absorbed and eliminated rapidly from the body. Its fast acting property makes it suitable for the on demand treatment of PE.
Authors
Andrianne R.
Journal
Rev Med Liege. 2013 Dec;68(12):655-60. Article in French.
Affiliation
Abstract
Premature ejaculation (PE) is a common sexual dysfunction, affecting approximately 20-24% of men. Managing PE has been a challenge for physicians and psycho-sexologists as well because no drug for PE has been approved by European (EMA) or U.S. (FDA) drug agencies. Over the past decade, clinical evidence has emerged indicating a beneficial effect of selective serotonin reuptake inhibitors (SSRIs), tramadol, penile anesthesia and, in some cases, inhibitors of phosphodiesterase type 5 for the treatment of men with PE. A psycho-sexological care helps support. In spite of their efficacy, adverse effects represent the major concern for the chronic use of SSRIs in patients with PE and they may prompt discontinuation from therapy. Dapoxetine, marketed as Priligy, is the first compound developed specially for the treatment of PE, on demand before intercourse. Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin's action at the postsynaptic cleft, and as a consequence promoting ejaculatory delay. Dapoxetine is quickly absorbed and eliminated rapidly from the body. Its fast acting property makes it suitable for the on demand treatment of PE.
John Juan
New member
Post from a Superior dapoxetine user on another forum...
"I bought some to try so I took a half dose to try out .5ml I'm glad I took only that I lasted a long time and when I wanted to quit I really had to focus on getting off for it to happen. So if I took 2ml it would be porn star stat. Also read about the side effects on it. Glad I have a extra tool for the bedroom. Great stuff it did make me feel tired earlier than normal too."
"I bought some to try so I took a half dose to try out .5ml I'm glad I took only that I lasted a long time and when I wanted to quit I really had to focus on getting off for it to happen. So if I took 2ml it would be porn star stat. Also read about the side effects on it. Glad I have a extra tool for the bedroom. Great stuff it did make me feel tired earlier than normal too."
John Juan
New member
Dapoxetine for the treatment of premature ejaculation: results from a randomized, double-blind, placebo-controlled phase 3 trial in 22 countries.
AuthorsBuvat J, et al. Show all Journal
Eur Urol. 2009 Apr;55(4):957-67. doi: 10.1016/j.eururo.2009.01.025. Epub 2009 Jan 21.
Affiliation
Comment in
Eur Urol. 2009 Apr;55(4):967-8.
Abstract
BACKGROUND: Dapoxetine is being developed for the on-demand treatment of premature ejaculation (PE). Previous clinical trials have demonstrated its safety and efficacy.
OBJECTIVE: To evaluate the long-term efficacy and safety of dapoxetine in men with PE.
DESIGN, SETTING, AND PARTICIPANTS: This randomized, double-blind, parallel-group, placebo-controlled, phase 3 trial, conducted in 22 countries, enrolled men (N=1162) > or = 18 yr of age who met the Diagnostic and Statistical Manual of Mental Disorders, fourth edition, text revision criteria for PE for > or = 6 mo, with an intravaginal ejaculatory latency time (IELT) < or = 2 min in > or = 75% of intercourse episodes at baseline.
INTERVENTION: Dapoxetine 30 mg or dapoxetine 60 mg or placebo on demand (1-3 h before intercourse) for 24 wk.
MEASUREMENTS: Stopwatch-measured IELT, Premature Ejaculation Profile (PEP), Clinical Global Impression (CGI) of change, adverse events (AEs).
RESULTS AND LIMITATIONS: The study was completed by 618 men. Mean average IELT increased from 0.9 min at baseline (all groups) to 1.9 min, 3.2 min, and 3.5 min with placebo and dapoxetine 30 mg and dapoxetine 60 mg, respectively, at study end point; geometric mean IELT increased from 0.7 min at baseline to 1.1 min, 1.8 min, and 2.3 min, respectively, at study end point. All PEP measures and IELTs improved significantly with dapoxetine versus placebo at week 12 and week 24 (p<0.001 for all). The most common AEs were nausea, dizziness, diarrhea, and headache. AEs led to discontinuation in 1.3%, 3.9%, and 8.2% of subjects with placebo and dapoxetine 30 mg and dapoxetine 60 mg, respectively. Limitations of this study included the exclusion of men who were not in long-term monogamous relationships.
CONCLUSIONS: Dapoxetine significantly improved all aspects of PE and was generally well tolerated in this broad population.
AuthorsBuvat J, et al. Show all Journal
Eur Urol. 2009 Apr;55(4):957-67. doi: 10.1016/j.eururo.2009.01.025. Epub 2009 Jan 21.
Affiliation
Comment in
Eur Urol. 2009 Apr;55(4):967-8.
Abstract
BACKGROUND: Dapoxetine is being developed for the on-demand treatment of premature ejaculation (PE). Previous clinical trials have demonstrated its safety and efficacy.
OBJECTIVE: To evaluate the long-term efficacy and safety of dapoxetine in men with PE.
DESIGN, SETTING, AND PARTICIPANTS: This randomized, double-blind, parallel-group, placebo-controlled, phase 3 trial, conducted in 22 countries, enrolled men (N=1162) > or = 18 yr of age who met the Diagnostic and Statistical Manual of Mental Disorders, fourth edition, text revision criteria for PE for > or = 6 mo, with an intravaginal ejaculatory latency time (IELT) < or = 2 min in > or = 75% of intercourse episodes at baseline.
INTERVENTION: Dapoxetine 30 mg or dapoxetine 60 mg or placebo on demand (1-3 h before intercourse) for 24 wk.
MEASUREMENTS: Stopwatch-measured IELT, Premature Ejaculation Profile (PEP), Clinical Global Impression (CGI) of change, adverse events (AEs).
RESULTS AND LIMITATIONS: The study was completed by 618 men. Mean average IELT increased from 0.9 min at baseline (all groups) to 1.9 min, 3.2 min, and 3.5 min with placebo and dapoxetine 30 mg and dapoxetine 60 mg, respectively, at study end point; geometric mean IELT increased from 0.7 min at baseline to 1.1 min, 1.8 min, and 2.3 min, respectively, at study end point. All PEP measures and IELTs improved significantly with dapoxetine versus placebo at week 12 and week 24 (p<0.001 for all). The most common AEs were nausea, dizziness, diarrhea, and headache. AEs led to discontinuation in 1.3%, 3.9%, and 8.2% of subjects with placebo and dapoxetine 30 mg and dapoxetine 60 mg, respectively. Limitations of this study included the exclusion of men who were not in long-term monogamous relationships.
CONCLUSIONS: Dapoxetine significantly improved all aspects of PE and was generally well tolerated in this broad population.
John Juan
New member
Post in my thread at pm....
"Paired Superior's Dapo with tadalafil on my honeymoon in the DR. All I can say is that I spent more time in our room than I had expected. I pity the poor maid who had to clean up. Lmao.
For me 2ml about 1.5 hours before sex is my sweet spot for Dapo. At this dose I can go as long as I want and then blow on command. On a higher dose I had to really concentrate and needed the wife to talk like a Bangkok whore for me to explode. Crazy! Also, at a higher dose I felt like I was drunk on cheap Vodka.
The only downside is my mouth burning like a mofo when shooing it. Almost feels swollen. Don't know how you could possibly hold this under your tongue for maximum absorption.
I tried other Dapo and nothing did anything like this stuff. I will be taking advantage of any Bogo specials.
As for the tadalafil, it's the first one to not give me a stuffy face feeling. Awesome chems from a great sponsor."
"Paired Superior's Dapo with tadalafil on my honeymoon in the DR. All I can say is that I spent more time in our room than I had expected. I pity the poor maid who had to clean up. Lmao.
For me 2ml about 1.5 hours before sex is my sweet spot for Dapo. At this dose I can go as long as I want and then blow on command. On a higher dose I had to really concentrate and needed the wife to talk like a Bangkok whore for me to explode. Crazy! Also, at a higher dose I felt like I was drunk on cheap Vodka.
The only downside is my mouth burning like a mofo when shooing it. Almost feels swollen. Don't know how you could possibly hold this under your tongue for maximum absorption.
I tried other Dapo and nothing did anything like this stuff. I will be taking advantage of any Bogo specials.
As for the tadalafil, it's the first one to not give me a stuffy face feeling. Awesome chems from a great sponsor."
FitnessSeattle
New member
And a question for the win - what about he opposite problem, male anorgasmia?
snooby1234
New member
What is the shelf life of dapox from superior?
John Juan
New member
If stored in a cool
Dry place the research liquids should all be good for a couple years.
