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cortisol
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GymIntensity
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TEST helps block cortisol, I dont know what the percentage is as far as how close to "completely".
Max102
New member
There are also several supplements that have been shown to possibly reduce cortisol levels:
Acetyl-L-carnitine (This supplement may help prevent the decline in testosterone that occurs during and after an intense resistance training session.),
L-Glutamine ( One study actually showed that
glutamine directly prevents the cortisol-induced degradation of
muscle contractile proteins.(3) ,
Vitamin C ,
Zinc (This vitamin, which is often times used for healthy skin function, may also minimize cortisol levels according to Dr. Sapse. He suggested this in an abstract he presented at the 1997 conference on cortisol and anti-cortisols. (4)), Vitamin A,Gingko Biloba,DHEA,
A good post workout drink that spikes insulin levels have been shown to help. Insulin actually interferes with cortisol and may enhance cortisol clearance from the body. Spiking insulin levels after a workout (by consuming a high-glycemic index
carbohydrate) may help minimize excessive cortisol levels since cortisol levels are elevated significantly post resistance training.
This study examined the short-term effects of the daily ingestion of ascorbic acid (1,000 mg/ d) on resting and postexercise
concentrations of serum cortisol (Cort), testosterone (T), and the
testosterone : cortisol ratio (T:C) in 17 junior elite weightlifters.
Subjects were assigned to one of two groups equated for body mass and weightlifting total. GAA received ascorbic acid each day. GP received a placebo similar in appearance to the ascorbic acid supplement.
Subjects participated in a competitive, high volume, high intensity
training program. Blood (fasting) was drawn 5 times: baseline, Day 16 preexercise, immediate post, 1-hr post, and 24 hrs post. Exercise consisted of typical large-muscle-mass exercises familiar to all subjects and was standardized based on relative intensity (% 1-RM). ANCOVA, using preexercise ascorbic acid concentrations as the covariant, showed a significant difference (p = 0.02) for cortisol at 24 hrs post. Testosterone or the T:C ratio did not differ between groups at any point.
You could also try Phosphadytylserine
Acetyl-L-carnitine (This supplement may help prevent the decline in testosterone that occurs during and after an intense resistance training session.),
L-Glutamine ( One study actually showed that
glutamine directly prevents the cortisol-induced degradation of
muscle contractile proteins.(3) ,
Vitamin C ,
Zinc (This vitamin, which is often times used for healthy skin function, may also minimize cortisol levels according to Dr. Sapse. He suggested this in an abstract he presented at the 1997 conference on cortisol and anti-cortisols. (4)), Vitamin A,Gingko Biloba,DHEA,
A good post workout drink that spikes insulin levels have been shown to help. Insulin actually interferes with cortisol and may enhance cortisol clearance from the body. Spiking insulin levels after a workout (by consuming a high-glycemic index
carbohydrate) may help minimize excessive cortisol levels since cortisol levels are elevated significantly post resistance training.
This study examined the short-term effects of the daily ingestion of ascorbic acid (1,000 mg/ d) on resting and postexercise
concentrations of serum cortisol (Cort), testosterone (T), and the
testosterone : cortisol ratio (T:C) in 17 junior elite weightlifters.
Subjects were assigned to one of two groups equated for body mass and weightlifting total. GAA received ascorbic acid each day. GP received a placebo similar in appearance to the ascorbic acid supplement.
Subjects participated in a competitive, high volume, high intensity
training program. Blood (fasting) was drawn 5 times: baseline, Day 16 preexercise, immediate post, 1-hr post, and 24 hrs post. Exercise consisted of typical large-muscle-mass exercises familiar to all subjects and was standardized based on relative intensity (% 1-RM). ANCOVA, using preexercise ascorbic acid concentrations as the covariant, showed a significant difference (p = 0.02) for cortisol at 24 hrs post. Testosterone or the T:C ratio did not differ between groups at any point.
You could also try Phosphadytylserine
celica
New member
by Bill Roberts - Cytadren, at moderate doses, is a fairly effective inhibitor of aromatase and a weak inhibitor of desmolase (an enzyme needed for the production of all steroids), and at higher doses becomes an effective inhibitor of desmolase. It is therefore useful when using aromatizable steroids, though it is not the drug of choice for this purpose.
Inhibition of desmolase -- the undesired side effect of Cytadren -- will lead, at least temporarily, to decreased production of cortisol. Contrary to the other claims, there is no evidence, nor good reason to believe, that reducing cortisol below normal would be of benefit to the weight training athlete, and considerable evidence that it is a bad idea. Thus, desmolase inhibition is to be avoided.
The claim that Cytadren significantly inhibits natural production of testosterone is not correct. The desmolase step is rate limiting for the production of cortisol, but not for testosterone: thus, a slowing of desmolase activity does not slow production of testosterone significantly. However, the conclusion that natural athletes should not use Cytadren is correct, but for a different reason. Natural athletes have no need of the antiaromatase activity, and the anti-desmolase activity, reducing cortisol below normal, is not desirable. It would only be desirable if cortisol levels were abnormally high, which should not be the case.
The claim that 2-4 tablets per day (500-1000 mg) should be taken is extraordinarily bad advice. I do not believe that more than 250 mg/day should be taken, and that should be taken very carefully, divided into 125 mg (half a tab) in the morning, and 62.5 mg (quarter tab) six and twelve hours after that. The two days on on, two days off idea is also not a good one, since that gives no antiaromatase activity half of the time.
It has been demonstrated that 250 mg/day is not much less effective than 1000 mg/day in inhibiting aromatase, but the smaller dose results in much less desmolase inhibition.
If desmolase has been substantially inhibited and then this is suddenly discontinued, cortisol rebound occurs. While the dosing protocol given above generally allows the user to stop "cold turkey," since desmolase inhibition is low, tapering down is nonetheless a good idea, and is in fact necessary if, inadvisedly, doses higher than recommended were used.
Inhibition of desmolase -- the undesired side effect of Cytadren -- will lead, at least temporarily, to decreased production of cortisol. Contrary to the other claims, there is no evidence, nor good reason to believe, that reducing cortisol below normal would be of benefit to the weight training athlete, and considerable evidence that it is a bad idea. Thus, desmolase inhibition is to be avoided.
The claim that Cytadren significantly inhibits natural production of testosterone is not correct. The desmolase step is rate limiting for the production of cortisol, but not for testosterone: thus, a slowing of desmolase activity does not slow production of testosterone significantly. However, the conclusion that natural athletes should not use Cytadren is correct, but for a different reason. Natural athletes have no need of the antiaromatase activity, and the anti-desmolase activity, reducing cortisol below normal, is not desirable. It would only be desirable if cortisol levels were abnormally high, which should not be the case.
The claim that 2-4 tablets per day (500-1000 mg) should be taken is extraordinarily bad advice. I do not believe that more than 250 mg/day should be taken, and that should be taken very carefully, divided into 125 mg (half a tab) in the morning, and 62.5 mg (quarter tab) six and twelve hours after that. The two days on on, two days off idea is also not a good one, since that gives no antiaromatase activity half of the time.
It has been demonstrated that 250 mg/day is not much less effective than 1000 mg/day in inhibiting aromatase, but the smaller dose results in much less desmolase inhibition.
If desmolase has been substantially inhibited and then this is suddenly discontinued, cortisol rebound occurs. While the dosing protocol given above generally allows the user to stop "cold turkey," since desmolase inhibition is low, tapering down is nonetheless a good idea, and is in fact necessary if, inadvisedly, doses higher than recommended were used.
Max102
New member
I'm interested in the oxytocin. Do you have any studies that show it reduces cortisol levels? I suffer from CSR (Central Serous Retinopathy) which is caused by high cortisol levels. I checked the ingredients of oxytocin and really didn't see anything in it that has been proven to reduce cortisol. I would like to try it though. Really don't want to waste the money on it though. I been dealing with high cortisol levels for years....mikefear said:
Last edited:
macrophage69alpha
New member
Psychoneuroendocrinology. 2005 Oct;30(9):924-9. Links
Intranasal oxytocin administration attenuates the ACTH stress response in monkeys.Parker KJ, Buckmaster CL, Schatzberg AF, Lyons DM.
Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, CA 94305-5485, USA. [email protected]
Social relationships protect against the development of stress-related psychiatric disorders, yet little is known about the neurobiology that regulates this phenomenon. Recent evidence suggests that oxytocin (OT), a neuropeptide involved in social bond formation, may play a role. This experiment investigated the effects of chronic intranasal OT administration on acute stress-induced hypothalamic-pituitary-adrenal (HPA) axis activation in adult female squirrel monkeys. Subjects were randomized to one of two experimental conditions. Monkeys were intranasally administered either 50 microg oxytocin (N = 6 monkeys) or 0 microg oxytocin (N = 6 monkeys)/300 microl saline once a day for eight consecutive days. Immediately after drug administration on the eighth day, all monkeys were exposed to acute social isolation. Blood samples for determinations of adrenocorticotropic hormone (ACTH) and cortisol concentrations were collected after 30 and 90 min of stress exposure. Consistent with an anti-stress effect, OT-treated monkeys exhibited lower ACTH concentrations compared to saline-treated monkeys after 90 min of social isolation (F(1,7) = 6.891; P = 0.034). No drug-related differences in cortisol levels were observed, indicating that OT does not directly attenuate the adrenal stress response. Intranasal peptide administration has been shown to penetrate the central nervous system, and research must determine whether intranasally delivered OT exerts its effect(s) at a pituitary and/or brain level. This primate model offers critical opportunities to improve our understanding of the anti-stress effects of OT and may lead to novel pharmacological treatments for stress-related psychiatric disorders.
as a note- cortisol and oxytocin brings up 331 hits on medline (as of today)
Intranasal oxytocin administration attenuates the ACTH stress response in monkeys.Parker KJ, Buckmaster CL, Schatzberg AF, Lyons DM.
Department of Psychiatry and Behavioral Sciences, Stanford University Medical School, CA 94305-5485, USA. [email protected]
Social relationships protect against the development of stress-related psychiatric disorders, yet little is known about the neurobiology that regulates this phenomenon. Recent evidence suggests that oxytocin (OT), a neuropeptide involved in social bond formation, may play a role. This experiment investigated the effects of chronic intranasal OT administration on acute stress-induced hypothalamic-pituitary-adrenal (HPA) axis activation in adult female squirrel monkeys. Subjects were randomized to one of two experimental conditions. Monkeys were intranasally administered either 50 microg oxytocin (N = 6 monkeys) or 0 microg oxytocin (N = 6 monkeys)/300 microl saline once a day for eight consecutive days. Immediately after drug administration on the eighth day, all monkeys were exposed to acute social isolation. Blood samples for determinations of adrenocorticotropic hormone (ACTH) and cortisol concentrations were collected after 30 and 90 min of stress exposure. Consistent with an anti-stress effect, OT-treated monkeys exhibited lower ACTH concentrations compared to saline-treated monkeys after 90 min of social isolation (F(1,7) = 6.891; P = 0.034). No drug-related differences in cortisol levels were observed, indicating that OT does not directly attenuate the adrenal stress response. Intranasal peptide administration has been shown to penetrate the central nervous system, and research must determine whether intranasally delivered OT exerts its effect(s) at a pituitary and/or brain level. This primate model offers critical opportunities to improve our understanding of the anti-stress effects of OT and may lead to novel pharmacological treatments for stress-related psychiatric disorders.
as a note- cortisol and oxytocin brings up 331 hits on medline (as of today)
macrophage69alpha
New member
as a note- creating alters is a violation of the TOS
FaCkEnBaSsTaRd said:
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