converting stored fat to energy. vets and experts needed.

[Ron Ritzman]

Oops, I should add that there is some evidence (not yet conclusive though) that chronic EC treatment actually increases Beta-3 ARs in obese people, while reducing leptin levels (and prolly reducing leptin resistance).

So there is less leptin but you're more sensitive to what remains. Almost sounds like an even trade off.

I'm assuming that whatever study was done used EC only without a hypocaloric diet so they could be sure the leptin reduction wasn't due to fat loss.

Again, I'm not sure what this means after discontinuation of the drugs, but it is clear that obese folks (compared to lean, non-dieting folks) have lower levels of Beta-3 ARs and, again, EC use may just 'normalize' their metabolism. I suspect this would also be true for lean dieters with a diet induced metabolic slow down.

Are the fat burning effects of EC due to the stimulation of B3s, B2s, or both? I also know there is a protein sparing effect with EC and assumed it was due to it's glycogen sparing effects but that could also be a Beta-2 thing.

 

[MS]

"So there is less leptin but you're more sensitive to what remains. Almost sounds like an even trade off.

I'm assuming that whatever study was done used EC only without a hypocaloric diet so they could be sure the leptin reduction wasn't due to fat loss.".........................................The drop in leptin ocurrs too rapidly, and independently of fat loss to be dircectly due to this. It appears to be a true increase in leptin sensitivity, but the down side of this MAY be (I'm speculating here) an increased rebound fat gain for lean individuals getting ultra lean with EC, since below a certain threshold, low leptin=rebound feeding.

"Are the fat burning effects of EC due to the stimulation of B3s, B2s, or both? I also know there is a protein sparing effect with EC and assumed it was due to it's glycogen sparing effects but that could also be a Beta-2 thing.".....................both. The best guess is that it's around 40% beta-3, although the beta-2 stimulation decreases with chronic use while the beta-3 may increase. The beta-2 is prolly what causes the initial agitation, loss of appetite, slowed gastric emptying etc...while the beta-3 increases thermogenesis.

 

[solidspine]

I have been on this board for three years, and this is my first visit to the diet discussion,


Looks like I will be visiting daily again!!!!!!!!!!!!!!!!!!!!!!!