cocaine

[spongebob]

not really. some people try using other drugs on the comedown, but then have to take something else when they start coming off that...so really, youre screwed.

well if she is strictly talking about the comedown after your coke has run out for the night then any benzo will work fine.

 

[spongebob]

Matt is right. Coke is an evil evil drug. I would have a cigarette boat if it wasn't for that crap. Don't mess with it. It is not worth it. TRUST ME ON THIS!!! Plus it makes ya skinny and screws up your muscle mass. Seems kinda stupid for anybody on a fitness board to do it. Weed at least makes ya eat which is good for building muscle.

there is something inside you that facilitates addiction regarding drug use.

 

[Mastardo]

Thats right, but I think weed is a healthier alternative for the comedown. A perk is that it can be smoked while coming down and the entire next day.

 

[spongebob]

WRONG.

http://science.education.nih.gov/supplements/nih2/addiction/images/guide/fig3.6.gif

http://science.education.nih.gov/supplements/nih2/addiction/guide/lesson3-1.htm

"A drug that is inhaled (smoked) reaches the brain very quickly. The inhaled drugs go directly from the lungs into the left side of the heart, where they enter the arterial circulation that carries them to the brain. Marijuana and nicotine are examples of drugs that are commonly taken into the body by inhalation (smoking). The intensity of the effect of inhaled drugs may be slightly less than that for injected drugs because less of the drug is taken into the body; some of the drug will be exhaled with the rest of the components of the smoke. A drug that is injected intravenously also travels quickly to the brain, where it can exert its effects. The rapid passage of injected heroin, for example, brings a high risk of overdose."

15 to 20 seconds to feel a hit of inhaled meth? Try 2 seconds. IV rushes are more overpowering once they hit you from what I have heard (and seen, although not with heroin so none of them passed out), but not as immediate and not as steep or choppy.

nowhere in your little paragraph does it say that inhalation is faster than injection. it only states they are both fast as methods of admin.

ive smoke meth, crack and coke. it is not 2 sec.

 

[juiceddreadlocks]

if crack is coke and coke is crack, and the brain treats them the same, then i would say that the method of administration may be the difference in the entensity of the high but not neccesarliy the addictive properties physically. probaly pshycologically.

in other words, the high is intense but it is shorter lived that snorting. so you have to do more to stay at baseline.

well i think the main difference is how well it can cross the Blood brain barrier.

 

[curling]

Man, I can't believe this drug has got 6 pages of responses if that don't tell ya that is is bad I don't what does.

 

[juve]

well i think the main difference is how well it can cross the Blood brain barrier.

No, not really. Spongebob is on the right track. Think of nicotine gum/patches and cigarettes. It is almost impossible to become addicted to gum/patch, whereas cigarettes are much different.
Crack permeates membranes and saturates capilaries much faster than just intranasal administration calling not only for a quicker, but also less sustainable and much more reinforcing response.
Overall crack is the culprit to cocaine's addiction statistic and potential, even though the statistic itself is not high (something like only 11% of regular users become addicted and regular use was estimated to be 51 days of administration - think here). Heroin does not even occupy the same niche as far addiction and pathways of exerting its actions - heroin users are much more susceptible to addiction, one of the reasons being is the way it is administered (IV) yilding a quick and bioefficient response.
Ecstasy and meth don't even lie in the same category as coke - ecstatcy has a fraction of DA affinity of coke whereas meth is far greater than coke; by the same token most effects of coke are DA-mediated with some GABA/5-ht reinforcement, whereas meth and MDMA are almost purely 5-ht mediated.

Alcohol is by far worse in its negative connotations than any of the above especially given the amounts people consume

 

[juve]

BTW, my comments about Easter Europe referred to widespread amyl-nitrate usage

 

[Optimus B]

well i think the main difference is how well it can cross the Blood brain barrier.

exactly.

just for clarification:

powdered cocaine (nasally administered, passes through the mucous membranes of the nasal cavity) = cocaine HCl, this is a polar compound, and doesn't enter the brain that quickly.

crack (smoked) = cocaine without the HCl molecule conjugated to it, this is less polar and can cross the BBB easier since it's more lipophillic.

 

[excugat]

Funny how hard core partiers, who do powdered coke, express such immense contempt for anyone who does crack. Like they are low life's in comparison.