Interesting read...
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Review Article, Am J Clin Nutr 2004;79:
352–61.
Effect of conjugated linoleic acid on body composition and plasma
lipids in humans: an overview of the literature1,2
Antonius HM Terpstra
ABSTRACT
Studies in mice have indicated that feeding diets containing 0.5–1%
conjugated linoleic acid (CLA) considerably reduces body fat. These
findings have attracted much interest because of the potential use of
CLA as a tool to promote weight loss in humans. Several CLA
studies in humans have now been published, and the objective of the
present review was to give an overview of these experiments. Most
of the studies were done in free-living subjects and were not strictly
controlled for nutrient and energy intakes. None of the studies found
a significant reduction in body weight, and only 2 studies showed a
significant but relatively small body fat–lowering effect. Some studies
suggested that CLA may have a tendency to increase lean body
mass. Furthermore, there are indications from animal studies that
CLA may have effects on plasma lipids. However, only one study in
humans showed a significant HDL-cholesterol-lowering effect of
CLA; in all the other studies, there were no significant effects on
plasma total, LDL-, and HDL-cholesterol concentrations or on
plasma triacylglycerol concentrations. Thus, the results of the studies
in humans indicate that the effect of CLA on body fat is considerably
less than that anticipated from mice studies and that CLA has
no major effect on plasma lipids. Am J Clin Nutr 2004;79:
352–61.
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